| Title: |
Perinatal inflammation exposure and developmental outcomes 7 years after neonatal arterial ischaemic stroke |
| Authors: |
Giraud, Antoine; Dinomais, Mickaël; Garel, Pauline; Chevin, Mathilde; Thébault, Guillaume; Renaud, Cyrille; Presles, Émilie; Raia‐Barjat, Tiphaine; Sébire, Guillaume; Chabrier, Stéphane |
| Contributors: |
Ministère de la Santé; Fondation Motrice; Fondation de France |
| Source: |
Developmental Medicine & Child Neurology ; volume 65, issue 8, page 1073-1080 ; ISSN 0012-1622 1469-8749 |
| Publisher Information: |
Wiley |
| Publication Year: |
2023 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Aim To test the association between perinatal inflammation exposure and Full‐Scale IQ (FSIQ) score 7 years after neonatal arterial ischaemic stroke (NAIS). Method We conducted a cross‐sectional ancillary study nested in a multicentric longitudinal French cohort of infants born at term with NAIS between November 2003 and October 2006. Seventy‐three children were included (45 males, 28 females). The a priori defined primary outcome measure was the FSIQ score assessed with the Wechsler Intelligence Scale for Children, Fourth Edition at 7 years of age. Results Seventeen (23%) of the included children were exposed to perinatal inflammation. Exposure to perinatal inflammation was independently associated with an increase of FSIQ score (coefficient 13.4, 95% confidence interval 1.3–25.4; p = 0.03). Children exposed to perinatal inflammation had a higher median cerebral volume, a lower median lesion volume, and less extensive lesion distributions compared to non‐exposed children. Interpretation We propose the existence of two NAIS categories: arteritis‐associated NAIS in children exposed to perinatal inflammation and embolism‐associated NAIS in children non‐exposed to perinatal inflammation. Identifying these two NAIS categories would open the possibility for specific curative strategies: anti‐inflammatory strategy in arteritis‐associated NAIS and recanalization strategy in embolism‐associated NAIS. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/dmcn.15522 |
| Availability: |
https://doi.org/10.1111/dmcn.15522; https://onlinelibrary.wiley.com/doi/pdf/10.1111/dmcn.15522; https://onlinelibrary.wiley.com/doi/full-xml/10.1111/dmcn.15522 |
| Rights: |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.E96CB8FC |
| Database: |
BASE |