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Evolocumab and clinical outcomes in patients with cardiovascular disease

Title:	Evolocumab and clinical outcomes in patients with cardiovascular disease
Authors:	Sabatine, Marc S.; Giugliano, Robert P.; Keech, Anthony C.; Honarpour, Narimon; Wiviott, Stephen D.; Murphy, Sabina A.; Kuder, Julia F.; Wang, Huei; Liu, Thomas; Wasserman, Scott M.; Sever, Peter S.; Pedersen; Terje R. Fish MP; Abrahamsen TE; Im K; Kanevsky E; Bonaca MP; Lira Pineda A; Hanlon K; Knusel B; Somaratne R; Kurtz C; Scott R; Accini Mendoza JL; Amerena J; Badariene J; Burgess L; Ceska R; Charng MJ; Choi D; Cobos JL; Dan GA; De Ferrari GM; Deedwania PC; Chopra VK; Erglis A; Ezhov MV; Ferreira J; Filipová S; Gaciong ZA; Pasierski T; Georgiev BG; Gonzalez-Galvez G; Gouni-Berthold I; Schäufele T; Hirayama A; Huber K; Rammer M; Kjaerulf Jensen H; Wermuth S; Jiang L; Jukema JW; Kraydashenko O; Leiter LA; Lewis BS; López-Miranda J; Lorenzatti AJ; Mach F; McAdam B; Nilsson L; Olsson Å; Rallidis L; Rogelio GG; Kerr Saraiva JF; Scheen A; Schiele F; Scott RS; Connolly D; Siu CW; Tay L; Thorgeirsson G; Tikkanen MJ; Tokgozoglu SL; Toth K; Viigimaa M; Wan Ahmad WA; Hennekens CH; Andreotti F; Baigent C; Brown WV; Davis BR; Newcomer JW; Wood SK; LaRosa J; Ansell B; Olsson A; Lowe C; Zahn L; Awtry E; Berger C; Croce K; Desai A; Gelfand E; Ho C; Leeman D; Link M; Norden A; Pande A; Rost N; Ruberg F; Silverman S; Singhal A; Vita J; Mackinnon I; Vogel DR; Leon de la Fuente R; Perna E; Amuchastegui M; Pacora F; Hershson A; Blumberg E; Glenny JA; Colombo H; Cuadrado JA; Nicolosi L; Rojas CG; Ulla MR; Hasbani EG; Cuneo C; Lopez Santi RG; Sanabria HD; Hrabar A; Lozada A; Begg A; Lehman S; Wittert G; Juergens C; Kostner K; Beltrame J; Simpson R; Sinhal A; Adams M; Kritharides L; Roberts Thomson P; Cross D; Thompson P; Van Gaal W; Cox N; Farshid A; Hammett C; Garrahy P; Prasan A; Horrigan M; Ebenbichler C; Hanusch U; Prager R; Schernthaner G; Luger A; Siostrzonek P; Toplak H; Bergler-Klein J; Paulweber B; Sinzinger H; Buysschaert I; Thoeng J; Vandekerckhove H; Catez E; Verheye S; Descamps O; Hoffer E; Wollaert B; Chenu P; van de Borne P; De Meulemeester M; Friart A; Charlier F; De Raedt H; Rietzschel E; Roelandt R; Lalmand J; Tavares Russo LA; Reis G; Duarte Barbosa EC; Vidotti MH; Fernandes Manenti ER; Dutra O; Leaes PE; Rech RL; Bertolim Precoma D; Nicolau JC; Amoedo R; Eliaschewitz FG; Pereira A; Kurtz Lisboa HR; Soares Piegas L; Cunha Borges JL; Ferreira Rossi PR; Pimentel Filho P; Bodanese LC; de Sa Cunha R; Moura Jorge JC; Ardito WR; Barroso de Souza WK; Hissa M; Izar MC; Manolova A; Kitova L; Kinova E; Tzekova M; Velchev V; Tarnovska-Kadreva R; Gotchev D; Petrov I; Raev D; Trendafilova-Lazarova D; Yotov Y; Lazov P; Rahimi S; St Amour E; Constance C; Pesant Y; Hess A; Anderson T; Sussex B; Henein S; Tsoukas G; Pandey AS; Bergeron J; Hart R; Gosselin G; Chehayeb R; Hamet P; Hartleib M; Mukherjee A; Halperin F; Petrella R; Bhargava R; Lonn E; Sabbah E; Bata I; Cha J; Gaudet D; Chapman K; Murthy D; Nigro F; Rupka D; Gossard D; Gupta M; Dowell A; Mansour S; Baass A; Geadah C; Huynh T; Peterson S; Poirier P; Sabe-Affaki G; Vertes G; Crowley D; Duchesne L; Pincetti Jofre CP; Potthoff Cardenas S; Conejeros Kindel C; Saavedra Gajardo VA; Lanas Zanetti F; Sepulveda Varela PA; Stockins Fernandez BA; Li W; Li D; Zhao S; Li Z; Wang J; Yang Y; Zhang L; Yang P; Zhang X; Huang H; Xue L; Zheng Z; Huang W; Dai H; 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Contributors:	Sabatine, Marc S.; Giugliano, Robert P.; Keech, Anthony C.; Honarpour, Narimon; Wiviott, Stephen D.; Murphy, Sabina A.; Kuder, Julia F.; Wang, Huei; Liu, Thoma; Wasserman, Scott M.; Sever, Peter S.; Pedersen; Terje R., Fish MP; Abrahamsen, Te; Im, K; Kanevsky, E; Bonaca, Mp; Lira Pineda, A; Hanlon, K; Knusel, B; Somaratne, R; Kurtz, C; Scott, R; Accini Mendoza, Jl; Amerena, J; Badariene, J; Burgess, L; Ceska, R; Charng, Mj; Choi, D; Cobos, Jl; Dan, Ga; De Ferrari, Gm; Deedwania, Pc; Chopra, Vk; Erglis, A; Ezhov, Mv; Ferreira, J; Filipová, S; Gaciong, Za; Pasierski, T; Georgiev, Bg; Gonzalez-Galvez, G; Gouni-Berthold, I; Schäufele, T; Hirayama, A; Huber, K; Rammer, M; Kjaerulf Jensen, H; Wermuth, S; Jiang, L; Jukema, Jw; Kraydashenko, O; Leiter, La; Lewis, B; López-Miranda, J; Lorenzatti, Aj; Mach, F; McAdam, B; Nilsson, L; Olsson, Å; Rallidis, L; Rogelio, Gg; Kerr Saraiva, Jf; Scheen, A; Schiele, F; Connolly, D; Siu, Cw; Tay, L; Thorgeirsson, G; Tikkanen, Mj; Tokgozoglu, Sl; Toth, K; Viigimaa, M; Wan Ahmad, Wa; Hennekens, Ch; Andreotti, F; Baigent, C; Brown, Wv; Davis, Br; Newcomer, Jw; Wood, Sk; LaRosa, J; Ansell, B; Olsson, A; Lowe, C; Zahn, L; Awtry, E; Berger, C; Croce, K; Desai, A; Gelfand, E; Ho, C; Leeman, D; Link, M; Norden, A; Pande, A; Rost, N; Ruberg, F
Publisher Information:	Massachussetts Medical Society; Waltham
Publication Year:	2017
Collection:	Sapienza Università di Roma: CINECA IRIS
Subject Terms:	Aged; antibodies; monoclonal; anticholesteremic agent; atherosclerosi; cardiovascular disease; cholesterol; ldl; double-blind method; drug therapy; combination; female; follow-up studie; human; hydroxymethylglutaryl-coa reductase inhibitor; hypercholesterolemia; incidence; least-squares analysi; male; middle aged; proprotein convertase 9; medicine (all)
Description:	BACKGROUND Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol levels by approximately 60%. Whether it prevents cardiovascular events is uncertain. METHODS We conducted a randomized, double-blind, placebo-controlled trial involving 27,564 patients with atherosclerotic cardiovascular disease and LDL cholesterol levels of 70 mg per deciliter (1.8 mmol per liter) or higher who were receiving statin therapy. Patients were randomly assigned to receive evolocumab (either 140 mg every 2 weeks or 420 mg monthly) or matching placebo as subcutaneous injections. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. The key secondary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The median duration of follow-up was 2.2 years. RESULTS At 48 weeks, the least-squares mean percentage reduction in LDL cholesterol levels with evolocumab, as compared with placebo, was 59%, from a median baseline value of 92 mg per deciliter (2.4 mmol per liter) to 30 mg per deciliter (0.78 mmol per liter) (P
Document Type:	article in journal/newspaper
Language:	English
Relation:	info:eu-repo/semantics/altIdentifier/pmid/28304224; info:eu-repo/semantics/altIdentifier/wos/WOS:000400442300005; volume:376; issue:18; firstpage:1713; lastpage:1722; numberofpages:10; journal:NEW ENGLAND JOURNAL OF MEDICINE; http://hdl.handle.net/11573/1150634
DOI:	10.1056/NEJMoa1615664
Availability:	http://hdl.handle.net/11573/1150634; https://doi.org/10.1056/NEJMoa1615664
Rights:	info:eu-repo/semantics/openAccess
Accession Number:	edsbas.E9FD749D
Database:	BASE