| Title: |
Subacute and subchronic methomyl exposure induced toxic effects on intestines via oxidative stress in male albino rats: biochemical and histopathological study |
| Authors: |
Chabane, Kahina; Khene, M’hammed Amine; Zaida, Faiza; Ainouz, Lynda; Giaimis, Jean; Mameri, Saâdia; Baz, Ahsene |
| Contributors: |
École normale supérieure - Kouba-Alger (ENS Kouba-Alger); Université des Sciences et de la Technologie Houari Boumediene = University of Sciences and Technology Houari Boumediene Alger (USTHB); Démarche intégrée pour l'obtention d'aliments de qualité (UMR QualiSud); Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Avignon Université (AU)-Université de La Réunion (UR)-Institut Agro Montpellier; Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM); Hôpital Mustapha Pacha Alger (CHUMA) |
| Source: |
ISSN: 0148-0545. |
| Publisher Information: |
CCSD; Taylor & Francis |
| Publication Year: |
2020 |
| Collection: |
Université de Montpellier: HAL |
| Subject Terms: |
subchronic; toxicity; subacute; oxidative stress; duodenum; colon; Methomyl; MESH: Animals; MESH: Antioxidants; MESH: Intestines; MESH: Liver; MESH: Male; MESH: Methomyl; MESH: Oxidative Stress; MESH: Rats; Wistar; [SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chain; [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition; [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health; [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology |
| Description: |
International audience ; The aim of the present study was to estimate the potential toxic effects of a subacute and a subchronic exposure to methomyl (MET) on some parts of the digestive system in male albino rats. Wistar rats were exposed daily by oral gavage to 4 mg/kg body weight (b.w.) of MET over 28 days in subacute experiments and to 1 mg/kg b.w. of MET for 90 consecutive days in subchronic exposure. Plasma levels of liver function indicators (ALT, AST, ALP and LDH) were significantly elevated after administration of MET to rats. MET had significant pro-oxidative effects on the intestines, as indicated by decreases in nonenzymatic (GSH) and enzymatic antioxidant (GPx, GST and CAT) parameters and significant increases in TBARS levels in both the duodenum and colon of rats. Microscopically, the duodenum and colon of rats exposed to MET showed severe pathological changes. It could be concluded that MET profoundly altered the structure and antioxidant status of intestinal rat tissue, which might lead to intestinal and digestive dysfunctions. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/32063051; PUBMED: 32063051 |
| DOI: |
10.1080/01480545.2020.1727496 |
| Availability: |
https://hal.science/hal-05449030; https://doi.org/10.1080/01480545.2020.1727496 |
| Accession Number: |
edsbas.EA02CD37 |
| Database: |
BASE |