| Title: |
P-1657. Difference in reactogenicity events between mRNA and Protein-subunit Vaccines: Results from the Booster Epidemiological Evaluation of Health, Illness, and Vaccine Efficacy (BEEHIVE) Study, a U.S. randomized trial of 2023-2024 COVID-19 vaccines (XBB.1.5) |
| Authors: |
Yoon, Sarang K; Thiese, Matthew S; Phillips, Andrew; Ellsworth, German L; Ball, Sarah W; Rowley, Elizabeth; Battan-Wraith, Steph; Fink, Rebecca; Yates, Adam; Toback, Seth; Dunkle, Lisa M; Rousculp, Matthew D; Zhao, Hongwei |
| Source: |
Open Forum Infectious Diseases ; volume 13, issue Supplement_1 ; ISSN 2328-8957 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2026 |
| Description: |
Background Vaccine reactogenicity, defined as local and systemic reactions, is a leading factor for COVID-19 vaccine hesitancy in adults1-4. As the perceived risk of COVID-19 decreases, individuals may become less permissive towards vaccine-associated adverse reactions.Figure 1.Study DesignFigure 2.Local and systemic reactogenicity events after Novavax or Pfizer vaccines within 1, 2, and 6 days Methods This double-blinded RCT compared two 2023-2024 (XBB.1.5) vaccines Novavax (NVX), a protein-based vaccine, and Pfizer-BioNTech (mRNA) over a 24-week period between Nov 2023 and Aug 2024 (Fig 1). Solicited reactogenicity symptoms (systemic and local), were evaluated using a post-vaccination questionnaire at 3-time intervals (1-, 2-, and 6-days post-vaccination). Reactogenicity was assessed for occurrence and maximum intensity (according to FDA toxicity grade). Tests for linear trend were performed.Figure 3.Summary of solicited systemic reactogenicity events after Novavax or Pfizer vaccines within 1 and 2 days post-vaccination Results 901 participants [mean age (SD): 40.5 (15.95); 55% female; White (91%); Hispanic (11%)] completed at least one of the questionnaires (NVX n=448; mRNA n=453); all previously received ≥2 doses of mRNA vaccines prior to enrollment with 89% reported receipt of ≥3 COVID-19 vaccinations and 60% reported a prior SARS-CoV-2 infection. In review of the solicited systemic reactogenicity during the first day post-vaccination, 62.1% of NVX recipients reported experiencing any event versus 75.8% of mRNA recipients (p< 0.05) (Fig 2). On average, NVX recipients experienced 1.4 symptoms versus 2.2 in mRNA recipients (Fig 3). 15.7% of NVX recipients experienced at least one symptom of Grade 2 or higher versus 33.6% of mRNA recipients. NVX recipients had much fewer grade 2 or 3 reactogenicity events than mRNA. An absolute difference of 11.7% fewer NVX versus mRNA recipients reported solicited local reactogenicity events. The occurrence and severity of the solicited reactogenic events were ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/ofid/ofaf695.1832 |
| Availability: |
https://doi.org/10.1093/ofid/ofaf695.1832; https://academic.oup.com/ofid/article-pdf/13/Supplement_1/ofaf695.1832/66354336/ofaf695.1832.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.EA28ED0 |
| Database: |
BASE |