Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson's Disease Dementia
| Title: | Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson's Disease Dementia |
|---|---|
| Authors: | Gonzalez MC; Tovar-Rios DA; Alves G; Dalen I; Williams-Gray CH; Camacho M; Forsgren L; Backstrom D; Lawson RA; Macleod AD; Counsell CE; Paquet C; DeLena C; D'Antonio F; Pilotto A; Padovani A; Blanc F; Falup-Pecurariu C; Lewis SJG; Rejdak K; Papuc E; Hort J; Nedelska Z; O'Brien J; Bonanni L; Marquie M; Boada M; Pytel V; Abdelnour C; Alcolea D; Beyer K; Tysnes O-B; Aarsland D; Maple-Grodem J |
| Source: | Movement Disorders Clinical Practice, 2023 |
| Publisher Information: | John Wiley and Sons Inc |
| Publication Year: | 2023 |
| Collection: | Newcastle University Library ePrints Service |
| Description: | © 2023 International Parkinson and Movement Disorder Society.Background: There is a need to better understand the rate of cognitive and motor decline of Dementia with Lewy bodies (DLB) and Parkinson's disease Dementia (PDD). Objectives: To compare the rate of cognitive and motor decline in patients with DLB and PDD from the E-DLB Consortium and the Parkinson's Incidence Cohorts Collaboration (PICC) Cohorts. Methods: The annual change in MMSE and MDS-UPDRS part III was estimated using linear mixed regression models in patients with at least one follow-up (DLB n = 837 and PDD n = 157). Results: When adjusting for confounders, we found no difference in the annual change in MMSE between DLB and PDD (−1.8 [95% CI −2.3, −1.3] vs. −1.9 [95% CI −2.6, −1.2] [P = 0.74]). MDS-UPDRS part III showed nearly identical annual changes (DLB 4.8 [95% CI 2.1, 7.5]) (PDD 4.8 [95% CI 2.7, 6.9], [P = 0.98]). Conclusions: DLB and PDD showed similar rates of cognitive and motor decline. This is relevant for future clinical trial designs. |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | unknown |
| Relation: | https://eprints.ncl.ac.uk/291359; https://eprints.ncl.ac.uk/fulltext.aspx?url=291359/AFBF2373-1532-4D5E-947B-10C594F9812A.pdf&pub_id=291359 |
| DOI: | 10.57711/k2k9-z260 |
| Availability: | https://doi.org/10.57711/k2k9-z260; https://eprints.ncl.ac.uk/291359 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.EA3B19C9 |
| Database: | BASE |