| Title: |
Diminished circadian and ultradian rhythms of human brain activity in pathological tissue in vivo |
| Authors: |
Thornton C; Panagiotopoulou M; Chowdhury FA; Diehl B; Duncan JS; Gascoigne SJ; Besne G; McEvoy AW; Miserocchi A; Smith BC; de Tisi J; Taylor PN; Wang Y |
| Source: |
Nature Communications, 2 October 2024 |
| Publisher Information: |
Springer Nature |
| Publication Year: |
2024 |
| Collection: |
Newcastle University Library ePrints Service |
| Description: |
© 2024 The Author(s). Chronobiological rhythms, such as the circadian rhythm, have long been linked to neurological disorders, but it is currently unknown how pathological processes affect the expression of biological rhythms in the brain. Here, we use the unique opportunity of long-term, continuous intracranially recorded EEG from 38 patients (totalling 6338 hours) to delineate circadian (daily) and ultradian (minute to hourly) rhythms in different brain regions. We show that functional circadian and ultradian rhythms are diminished in pathological tissue, independent of regional variations. We further demonstrate that these diminished rhythms are persistent in time, regardless of load or occurrence of pathological events. These findings provide evidence that brain pathology is functionally associated with persistently diminished chronobiological rhythms in vivo in humans, independent of regional variations or pathological events. Future work interacting with, and restoring, these modulatory chronobiological rhythms may allow for novel therapies. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
https://eprints.ncl.ac.uk/301588; https://eprints.ncl.ac.uk/fulltext.aspx?url=301588/BACA4F47-F7AD-45A1-972A-9442174C5187.pdf&pub_id=301588 |
| Availability: |
https://eprints.ncl.ac.uk/301588 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.EA539A74 |
| Database: |
BASE |