| Title: |
Chlamydial protease-like activity factor targets SLC7A11 for degradation to induce ferroptosis and facilitate progeny releases |
| Authors: |
Chen, Wentao; Su, Xin; Pan, Yuying; Zhou, Han; Gao, Yidan; Wang, Xuemei; Jiang, Lijuan; Zeng, Lihong; Xu, Qingqing; Yu, Xueying; Yin, Xiaona; Feng, Zhanqin; Zhang, Bao; Zhao, Wei; Xue, Yaohua; Tang, Lingli; Zheng, Heping |
| Contributors: |
Zhong, Guangming; National Natural Science Foundation of China; Guangzhou Municipal Science and Technology Project; Natural Science Foundation of Guangdong Province; Guangdong Basic and Applied Basic Research Foundation; Construction of the Pathogenic Microorganism (Toxin) Strain Resource Bank Capacity Project of The Second Xiangya Hospital, Central South University |
| Source: |
PLOS Pathogens ; volume 21, issue 4, page e1013060 ; ISSN 1553-7374 |
| Publisher Information: |
Public Library of Science (PLoS) |
| Publication Year: |
2025 |
| Collection: |
PLOS Publications (via CrossRef) |
| Description: |
Chlamydia trachomatis, the most prevalent bacterial agent of sexually transmitted infections , poses a significant threat to reproductive health. The release of progeny through the orchestrated lysis of host cells plays a crucial role for the development of new infections, though the underlying molecular mechanisms remaining largely unexplored. In this study, we identified a novel mechanism by which Chlamydia induces host cell ferroptosis to facilitate its progeny release. This process involves the degradation of the host protein SLC7A11 by the chlamydial protease-like activity factor (CPAF), resulting in glutathione depletion and subsequent cell death characterized by lipid peroxidation. Infection with a CPAF-deficient strain fails to induce host cell ferroptosis. Notably, inhibiting ferroptosis by vitamin E reduces the Chlamydia burden in low genital tract of mice and trends toward attenuation of pathology. These findings provide new insights into the conserved survival strategies of Chlamydia and understanding of its pathogenesis. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1371/journal.ppat.1013060 |
| Availability: |
https://doi.org/10.1371/journal.ppat.1013060; https://dx.plos.org/10.1371/journal.ppat.1013060 |
| Rights: |
http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.EA5E00FA |
| Database: |
BASE |