A non-canonical lymphoblast in refractory childhood T-cell leukaemia
| Title: | A non-canonical lymphoblast in refractory childhood T-cell leukaemia |
|---|---|
| Authors: | Lim BSJ; Whitfield HJ; Trinh MK; Bloye G; Thomas R; Anderson ND; Wenger A; Hodder A; Treger TD; Lee-Six H; Coorens THH; Parks C; Ogbonnah T; Polonen P; Mullighan CG; Teachey DT; Xu J; Tan K; Hagleitner M; Kester L; van Leeuwen FN; Beattie G; Mansour MR; Williams O; Bartram J; Adams S; Jardine L; Behjati S; O'Connor D |
| Source: | Nature Communications, December 2025 |
| Publisher Information: | Springer Nature |
| Publication Year: | 2025 |
| Collection: | Newcastle University Library ePrints Service |
| Description: | © The Author(s) 2025. Refractory cancers may arise either through the acquisition of resistance mechanisms or represent distinct disease states. The origin of childhood T-cell acute lymphoblastic leukaemia (T-ALL) that does not respond to initial treatment, i.e. refractory disease, is unknown. Refractory T-ALL carries a poor prognosis and cannot be predicted at diagnosis. Here, we perform single cell mRNA sequencing of T-ALL from 58 children (84 samples) who did, or did not respond to initial treatment. We identify a transcriptionally distinctive blast population, exhibiting features of innate-like lymphocytes, as the major source of refractory disease. Evidence of such blasts at diagnosis heralds refractory disease across independent datasets and is associated with survival in a large, contemporary trial cohort. Our findings portray refractory T-ALL as a distinct disease with the potential for immediate clinical utility. |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | unknown |
| Relation: | https://eprints.ncl.ac.uk/308933; https://eprints.ncl.ac.uk/fulltext.aspx?url=308933/DB681594-5FCB-4118-8658-8CDC458BE858.pdf&pub_id=308933 |
| Availability: | https://eprints.ncl.ac.uk/308933 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.EA672CD9 |
| Database: | BASE |