Childhood Maltreatment and Deviations from Normative Brain Structure:A Mega-Analysis of 3,711 Individuals from the ENIGMA MDD and ENIGMA PTSD Working Groups
| Title: | Childhood Maltreatment and Deviations from Normative Brain Structure:A Mega-Analysis of 3,711 Individuals from the ENIGMA MDD and ENIGMA PTSD Working Groups |
|---|---|
| Authors: | Wang, Haley R; Liu, Zhen-Qi; Pozzi, Elena; Hussain, Ahmed; Sigar, Priyanka; Abdallah, Chadi; Alexander, Nina; Baker, Justin; Bauer, Jochen; Blackford, Jennifer Urbano; Cisler, Josh; Connolly, Colm G; Cotton, Andrew; Daniels, Judith; Dannlowski, Udo; Densmore, Maria; deRoon-Cassini, Terri; Dima, Danai; Du Plessis, Stefan; Etkin, Amit; Fani, Negar; Fisch, Lukas; Fitzgerald, Jacklynn; Frodl, Thomas; Fu, Cynthia H Y; Gonul, Ali Saffet; Gordon, Evan M; Gotlib, Ian; Goya-Maldonado, Roberto; Groenewold, Nynke A; Grotegerd, Dominik; Hahn, Tim; Hamilton, J Paul; Han, Laura; Harpaz-Rotem, Ilan; Haswell, Courtney C; Herringa, Ryan; Herzog, Julia; Ipser, Jonathan; Jahanshad, Neda; Jovanovic, Tanja; Kaufman, Milissa; Kircher, Tilo; Konowski, Maximilian; Koopowitz, Sheri-Michelle; Krug, Axel; Krystal, John; Lanius, Ruth; Larson, Christine; Lazarov, Amit; Lebois, Lauren; Leehr, Elisabeth; Levy, Ifat; Li, Meng; Manthey, Antje; Maron-Katz, Adi; McIntosh, Andrew; McLaughlin, Katie; Meinert, Susanne; Mwangi, Benson; Nelson, Steven M; Nenadić, Igor; Neria, Yuval; Neufeld, Richard; Ojha, Amar; Olatunji, Bunmi; Olson, Elizabeth A; Opel, Nils; Peverill, Matthew; Ressler, Kerry; Ross, Marisa; Rosso, Isabelle; Sacchet, Matthew; Sambrook, Kelly; Schmahl, Christian; Seedat, Soraya; Shenton, Martha E; Sicorello, Maurizio; Sierk, Anika; Soares, Jair C; Stein, Dan J; Stein, Frederike; Stein, Murray B; Suarez-Jimenez, Benjamin; Théberge, Jean; Thomopoulos, Sophia I; Tomas, Carissa; Usemann, Paula; van den Heuvel, Leigh L; van Rooij, Sanne; Walter, Henrik; Walter, Martin; Wang, Xin; Whalley, Heather; Winter, Nils R; Wu, Mon-Ju; Xie, Hong; Yang, Tony; Zhu, Xi; Zilcha-Mano, Sigal; Zunta-Soares, Giovana B; Frangou, Sophia; Thompson, Paul M; Salminen, Lauren; Sun, Delin; Morey, Rajendra; Stevens, Jennifer S; Schmaal, Lianne; Ho, Tiffany C |
| Source: | Wang, H R, Liu, Z-Q, Pozzi, E, Hussain, A, Sigar, P, Abdallah, C, Alexander, N, Baker, J, Bauer, J, Blackford, J U, Cisler, J, Connolly, C G, Cotton, A, Daniels, J, Dannlowski, U, Densmore, M, deRoon-Cassini, T, Dima, D, Du Plessis, S, Etkin, A, Fani, N, Fisch, L, Fitzgerald, J, Frodl, T, Fu, C H Y, Gonul, A S, Gordon, E M, Gotlib, I, Goya-Maldonado, R, Groenewold, N A, Grotegerd, D, Hahn, T, Hamilton, J P, Han, L, Harpaz-Rotem, I, Haswell, C C, Herringa, R, Herzog, J, Ipser, J, Jahanshad, N, Jovanovic, T, Kaufman, M, Kircher, T, Konowski, M, .... |
| Publication Year: | 2026 |
| Collection: | King's College, London: Research Portal |
| Description: | Background Childhood maltreatment (CM), encompassing abuse and neglect, is highly prevalent and associated with elevated risk for Major Depressive Disorder (MDD), Posttraumatic Stress Disorder (PTSD), and other related conditions. The extent to which neuroanatomical alterations in MDD and PTSD are attributable to CM, however, is uncertain. Methods Here, we analyzed CM and whole-brain MRI data from 3,711 participants in the ENIGMA MDD and PTSD Working Groups (25 sites; 33.3±13.0 years; 59.9% female). Normative modeling estimated deviation z-scores for 14 subcortical volumes (SV), 68 cortical thickness (CT), and 68 surface area (SA) measures. To identify transdiagnostic effects, associations between CM and brain deviation scores were evaluated across all participants (patients and healthy controls) stratified by sex and three age bins (pediatric, young adult, older adult). Results In young adults (ages 18-35), abuse was associated with larger volumes in thalamus and pallidum, thinner isthmus cingulate and middle frontal regions, and thicker medial orbitofrontal cortex; there were no significant effects in pediatric (≤18 years) participants. The strongest effects were observed in young female adults (|β|=.07-.22, q |
| Document Type: | article in journal/newspaper |
| Language: | English |
| ISSN: | 0006-3223; 1873-2402 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/41791639; info:eu-repo/semantics/altIdentifier/pissn/0006-3223; info:eu-repo/semantics/altIdentifier/eissn/1873-2402 |
| DOI: | 10.1016/j.biopsych.2026.02.016 |
| Availability: | https://kclpure.kcl.ac.uk/portal/en/publications/9b5a76c6-7d81-448a-9d9b-509ce747ba8a; https://doi.org/10.1016/j.biopsych.2026.02.016 |
| Rights: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: | edsbas.EA7B517 |
| Database: | BASE |