| Title: |
Comparison of the immunological and virological responses to cART between HIV-1/O and HIV-1/M patients followed up in France |
| Authors: |
Unal, Guillemette; Seng, Rémonie; Alessandri-Gradt, Elodie; Plessis, Lorraine; Ghislain, Mathilde; Goujard, Cécile; Leoz, Marie; Plantier, Jean-Christophe; Meyer, Laurence; Duvivier, Claudine; Touam, Fatima; Pialoux, Gilles; Le Nagat, Sophie; Slama, Laurence; Chas, Julie; L'Yavanc, Thomas; Capeau, Jacqueline; Vigouroux, Corinne; Fellahi, Soraya; Bastard, Jean-Philippe; Viard, Jean-Paul; Maignan, Aline; Cros, Agnès; Sobel, Alain; Gérard, Laurence; Séréni, Daniel; van Dien, Le; Molina, Jean-Michel; Lascoux-Combe, Caroline; Aslan, Alexandre; Balkan, Suna; Colin de Verdière, Nathalie; de Castro, Nathalie; Delgado, Jeanine; Parlier, Sylvie; Pintado, Claire; Ponscarme, Diane; Rozenbaum, Willy; Taulera, Olivier; Gallien, Sébastien; Garrait, Valérie; Gatey, Caroline; Gazaignes, Sandrine; Goguel, Jérôme; Lafaurie, Matthieu; Munier, Anne-Lise; Bergmann, Jean-François; Rami, Agathe; Parrinello, Maguy; Girard, Pierre-Marie; Bottero, Julie; Ouazene, Zineb; Lefebvre, Bénédicte; Vacin, Nadia; Campa, Pauline; Boccens, Diane; Herson, Serge; Remidi, Hassiba; Iguertsira, Malik; Nafissa, Smaïl; Lupin, Catherine; Simon, Anne; Edeb, Nadia; Salmon-Céron, Dominique; Guillevin, Loïc; Tahi, Tassadit; Pierre Pietri, Marie; Weiss, Laurence; Pavie, Juliette; Karmochkine, Marina; Batisse, Dominique; Buisson, Martin; Derouineau, Jean; Manea, Maria; Lucas, Marie-Laure; Sophie, Matheron; Pahlavan, Golriz; Paput, Emmanuelle; Louni, Françoise; Harent, Stanislas; Legal, Sylvie; Castor, Guylaine; Bao, Phung; Fournier, Isabelle; Pascal Julia Zelie, Ralaimazava; Godard, Cindy; Boué, François; Martinez, Valérie; Miekoutima, Elsa; Favier, Marion; Pignon, Carole; Chambrin, Véronique; Kansau, Imad; Renato, Fior; Raho-Moussa, Mariem; Fantin, Bruno; Uludag, Agnès; Tadlaoui, Ali; Poder, Caroline; Iwaka Bamae, Valentin; Makloufi, Sihasi; Honoré, Patricia; Bouchaud, Olivier; Aberall, Sophie; Quertainmont, Yann; Sterpu, Raluca; Fourreau, Frédéric; Peretti, Delphine; Pindi Sala, Taylor; Bourdic, Katia; Levy, Yves; Lelièvre, Jean-Daniel; Dominguez, Stéphanie; Melica, Giovanna; Belzunce, Carine; Saidani, Maryline; Lascaux, Anne-Sophie; Luis Lopez Zaragoza, Jose; Dumont, Cécile; Cabié, André; Abel, Sylvie; Hochedez, Patrick; Ronin, François; Batalla, Anne-Sophie; Cerland, Christophe; Poizot-Martin, Isabelle; Ritleng, Anne-Suzel; Guignard, Meriem; Croarec, Nicolas; Blanco Bétancourt, Carle; Zaegel-Faucher, Olivia; Ivanova, Alena; Carmantrand, Marie-Josèphe; Mokhtari, Saadia; Thiebaut-Drobacheff, Marie-Christine; Foltzer Cécile Haffner-Mauvais, Adeline; Parcelier, François; Gardiennet, Quentin; Chireuze, Catherine; Faucher, Jean-François; Hustache-Mathieu, Laurent; Illes, Gabriella; Neau, Didier; Cazanave, Charles; Pistone, Thierry; Dupon, Michel; Dauchy, Frédéric; Dutronc, Hervé; Raymond, Isabelle; Lacaze-Buzy, Laetitia; Morlat, Philippe; Paccalin, François; Caldato, Sabrina; Roger-Schmeltz, Julien; Pertusa, Marie-Carmen; Receveur, Marie-Catherine; Martell, Cédric; Lacoste, Denis; Duffau, Pierre; Hessamfar, Mojgan; Reynes, Jacques; Crisol, Claude; Baillat, Vincent; Le Moing, Vincent; Jacquet, Jean-Marc; Casanova, Marie-Laure; Makinson, Alain; Villadoro, Antoine; Favier, Carine; Psomas, Cristina; Merle de Boever, Corinne; Tramoni, Christine; Bernard, Louis; Nau, Pascale; Sajole, Gaëlle; Sèvre, Carine; Soufflet, Antoine; Guadagnin, Patrick; Bastides, Frédéric; Choutet, Patrick; Raffi, François; Anavena, Clothilde; Colas, Martine; Larmet, Laurence; Morineau Le Houssinc, Pascale; Brunet-Cartier, Cécile; Reliquet, Véronique; Point, Patrick; Aubry, Olivier; Hue, Hervé; May, Thierry; Bouillon, Marie-Pierre; Delestan, Mickaël; André, Marie; Chéret, Antoine; Ajana, Faiza; Alcaraz, Isabelle; Baclet, Véronique; Biekre, Raphaël; Melliez, Hugues; Valette, Michel; Viget, Nathalie; Huleux, Thomas; Aïssi, Emmanuelle; Rey, David; Partisani, Marialuisa; Cheneau, Christine; Priester, Michèle; Batard, Marie-Laure; Mohseni Zadeh, Mahsa; Richard, Aurélie; Blaison, Gilles; Martinot, Martin; Pachard, Anne; Makhloufi, Djamila; Livrozet, Jean-Michel; Chiarello, Pierre; Brunel-Dalmas, Florence; Garnier, Florence; Chidiac, Christian; Augustin-Normand, Claude; Koffi, Joseph; Miailhes, Patrick; Pailhes, Sophie; Schlienger, Isabelle; Perpoint, Thomas; Boibieux, André; Brochier, Corinne; Perré, Philippe; Bolengia Stragia, Olivia; Guimant, Thomas; Leautez Nainville, Sophie; Luc Esnault, Jean; Laine, Laetitia; Rabille, Nadine; Albrecht, Catherine; Durand, Hélène; Suaud, Isabelle; Chennebault, J; Fialaire, P; Le Guillou-Guillemette, H; Rehaiem, S; Chanzy, B; Clavere, G; Gaillat, J; Courdavault, L; Genet, P; Gerbe, J; Benoit, C; Honore Bouakline, S; Waldner, A; Bettinger, D; Chirouze, C; Bernard, N; Reigadas, S; Dupont, X; L Gaillard, J; Gault, E; Reimann, E; Otterbein, G; Thomas, L; Vaghefi, P; Benoit, M; Buthiot, N; Goux, A; Chambrin, V; Deback, C; Fior, R; Raho Moussa, M; Antoniotti, O; Coban, D; Cormerais, L; Henquell, C; Jacomet, C; Lesens, O; Chanoine, N; Villmant, A; L van Autreve, J; Bloch, M; Ichou, H; Manceron, V; Mortier, E; Zeng, A; Bouvier-Alias, M; Dominguez, S; S Lascaux-Cametez, A; D Lelievre, J; Levy, Y; Melica-Gregoire, G; M Pawlotsky, J; Pothier, P; Inchiappa, L; Verhaeghe, A; Olivier, B; P Pathe, J; Berthe, H; Mathez, D; Favret, V; Troisvallets, D; Vandemeulebroucke, E; Ceccaldi, J; El Harif, Z; Bocket, L; Barbut, P; Chaix, F; Lambert, C; Lambolez, T; Miatezila, J; Son, O; Brunet, P; Chappe, C; Dhiver, C; Lecomte, V; Meddeb, L; Poizot-Martin, I; Tamalet, C; Valadier, J; Beck-Wirth, G; Benomar, M; M Delarbre, J; M Peter, J; Bevilacqua, S; Venard, V; Daneluzzi, V; Idri, N; Montoya, B; Ferre, V; Garnier, E; Hue, H; Larmet, L; Point, P; Raffi, F; Reliqiet, V; Rodallec, A; Secher, S; Amoyel, P; Botton, E; Janowski, M; Le Cocguic, Y; Deleplanque, P; M Descamps, J; Lapine, M; Sunder, S; Chansombat, M; Charpentier, C; Damond, F; Diallo, B; Duval, X; Julia, Z; Landman, R; Legac, S; Rioux, C; Yeni, P; Krivine, A; Blanche, P; Cros, A; Gazalet, P; Ghosn, J; Sobel, A; Bercot, B; Diemer, M; Parrinello, M; Bey Boumezrag, C; Bodard, L; Gibert, S; X Huche, F; Raffenne, L; Strebler, M; Blanc, C; Bourzam, E; Hansel, B; Lupin, C; Wirden, M; Collias, L; Effa, J; Jung, C; Pavie, J; Pere, H; Si Mohamed, A; Delaugerre, C; Gerard, L; Loze, B; Maylin, S; Nabias, R; Ponscarme, D; Deleuze, J; Rozenberg, F; Bachour, B; Bani-Sadr, F; Chas, J; Hamidi, M; Kherallah, L; Le Nagat, S; Le Pendeven, C; Moreau, F; C Nicolas, J; Schneider, V; D Tabone, M; Vaudre, G; Giraudeau, G; Le Moal, G; Plainchamp, D; Blondin, G; Dorval, I; C Duthe, J; Perfezou, P; L Berger, J; Brodard, V; Kmiec, I; Rouger, C; Strady, C; M Chappelin, J; Maillard, A; Ratajczak, M; Debab, Y; de Oliveira, F; Depatureaux, A; Gueit, I; Lemee, V; Theron, D; Pasdeloup, I; Camps, P; Bigaillon, C; Ficko, C; Imbert, C; Rapp, C; Grand, C; Michau, C; Bornarel, D; Devillier, P; Farfour, E; Majerholc, C; Vignon, D; Zucman, D; El Addouli, M; F Danjoux, M; Journe, J; Leveneur, Y; Marchou, B; Nicot, F; Prevoteau Du Clary, F; Bonne, S |
| Contributors: |
Institut National de la Santé et de la Recherche Médicale (INSERM); Université de Rouen Normandie (UNIROUEN); Normandie Université (NU); Université de Caen Normandie (UNICAEN); Centre de recherche en épidémiologie et santé des populations (CESP); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse; AP-HP. Université Paris Saclay-AP-HP. Université Paris Saclay-Institut National de la Santé et de la Recherche Médicale (INSERM); Université Paris-Saclay |
| Source: |
ISSN: 0305-7453. |
| Publisher Information: |
CCSD; Oxford University Press (OUP) |
| Publication Year: |
2025 |
| Collection: |
Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| Subject Terms: |
Cart; [SDV.IMM]Life Sciences [q-bio]/Immunology |
| Description: |
International audience ; Abstract Background Therapeutic outcomes for patients infected by genetically divergent HIV-1/O are not well-known due to scarce data and the lack of an appropriate comparison with patients infected by pandemic HIV-1/M. We aimed to compare the immunological and virological response to cART between HIV-1/O and HIV-1/M patients followed in France. Methods All naïve HIV-1/O subjects initiating cART in France in ANRS-ORIVAO study were compared to naïve HIV-1/M subjects initiating cART in ANRS-COPANA cohort. Piecewise linear mixed-effect models and Kaplan–Meier survival curves were used to analyse immunological and virological response to cART overall (65 HIV-1/O versus 279 HIV-1/M), then only in patients initiating 2INTI + 1PI/r. Results Plasma viral load (pVL) at treatment initiation was 0.6 log10 copies/mL lower in HIV-1/O than in HIV-1/M patients (P = 0.004) in the overall population, but there was no difference in the time to pVL < 200 cp/mL after cART initiation (log rank test, P = 0.57). Meanwhile, baseline CD4 counts were lower in HIV-1/O (median 180/mm3) than HIV-1/M (248/mm3) patients (P = 0.001). At 4 months, the increase in CD4 counts did not differ (P = 0.96) between groups but remained lower in HIV-1/O patients beyond 4 months of treatment (P = 0.04). In PI/r population, baseline pVL was 1 log10 copies/mL lower for HIV-1/O than HIV-1/M patients, leading to significantly faster attainment of pVL < 200 cp/mL (log rank test: P < 0.001); immunological response to cART was similar. Conclusions HIV-1/O and HIV-1/M immunological and virological responses to cART did not differ when epidemiological characteristics of the patients were taken into account. In France, treating HIV-1/O following HIV-1/M guidelines leads to similar therapeutic outcomes. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/39804210; PUBMED: 39804210 |
| DOI: |
10.1093/jac/dkae475 |
| Availability: |
https://hal.science/hal-04954157; https://doi.org/10.1093/jac/dkae475 |
| Accession Number: |
edsbas.EACFD935 |
| Database: |
BASE |