| Title: |
Prognostic value of total tumor volume in patients with colorectal liver metastases:A secondary analysis of the randomized CAIRO5 trial with external cohort validation |
| Authors: |
Michiel Zeeuw,J.; Wesdorp,Nina J.; Ali,Mahsoem; Bakker,Anne Joëlle J.J.; Voigt,Kelly R.; Starmans,Martijn P.A.; Roor,Joran; Kemna,Ruby; van Waesberghe,Jan Hein T.M.; van den Bergh,Janneke E.; Nota,Irene M.G.C.; Moos,Shira I.; van Dieren,Susan; van Amerongen,Martinus J.; Bond, Marinde J.G.; Chapelle,Thiery; van Dam,Ronald M.; Engelbrecht,Marc R.W.; Gerhards,Michael F.; van Gulik,Thomas M.; Hermans,John J.; de Jong,Koert P.; Klaase,Joost M.; Kok,Niels F.M.; Leclercq,Wouter K.G.; Liem,Mike S.L.; van Lienden, Krijn P.; Quintus Molenaar, I.; Patijn,Gijs A.; Rijken,Arjen M.; Ruers,Theo M.; de Wilt,Johannes H.W.; Verpalen, Inez M.; Stoker,Jaap; Grunhagen,Dirk J.; Swijnenburg,Rutger Jan; Punt,Cornelis J.A.; Huiskens,Joost; Verhoef,Cornelis; Kazemier,Geert; Hart- en Vaatziekten Team A; Epi Kanker Team B; Cancer; MS CGO; Zorgeenheid Kinderchirurgie Medisch; Researchgr. Beeldg. Moleculaire Interv. |
| Publication Year: |
2024 |
| Subject Terms: |
Colorectal cancer; Liver metastases; Systemic therapy; Local treatment tumor volume; Prognostic marker; Oncology; Cancer Research; Journal Article |
| Description: |
Background: This study aimed to assess the prognostic value of total tumor volume (TTV) for early recurrence (within 6 months) and overall survival (OS) in patients with colorectal liver metastases (CRLM), treated with induction systemic therapy followed by complete local treatment. Methods: Patients with initially unresectable CRLM from the multicenter randomized phase 3 CAIRO5 trial (NCT02162563) who received induction systemic therapy followed by local treatment were included. Baseline TTV and change in TTV as response to systemic therapy were calculated using the CT scan before and the first after systemic treatment, and were assessed for their added prognostic value. The findings were validated in an external cohort of patients treated at a tertiary center. Results: In total, 215 CAIRO5 patients were included. Baseline TTV and absolute change in TTV were significantly associated with early recurrence (P = 0.005 and P = 0.040, respectively) and OS in multivariable analyses (P = 0.024 and P = 0.006, respectively), whereas RECIST1.1 was not prognostic for early recurrence (P = 0.88) and OS (P = 0.35). In the validation cohort (n = 85), baseline TTV and absolute change in TTV remained prognostic for early recurrence (P = 0.041 and P = 0.021, respectively) and OS in multivariable analyses (P < 0.0001 and P = 0.012, respectively), and showed added prognostic value over conventional clinicopathological variables (increase C-statistic, 0.06; 95 % CI, 0.02 to 0.14; P = 0.008). Conclusion: Total tumor volume is strongly prognostic for early recurrence and OS in patients who underwent complete local treatment of initially unresectable CRLM, both in the CAIRO5 trial and the validation cohort. In contrast, RECIST1.1 did not show prognostic value for neither early recurrence nor OS. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/plain |
| Language: |
English |
| ISSN: |
0959-8049 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/453251 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/453251 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.EAE85C41 |
| Database: |
BASE |