| Title: |
PRECLINICAL EXPERIMENTAL THERAPEUTICS AND PHARMACOLOGY |
| Authors: |
Pavel, Helena; Ajeawung, Norbert; Faure, Robert; Poirier, Donald; Kamnasaran, Deepak; Joshi, Harish; Lun, Xueqing; Zemp, Franz; Sun, Beichen; Stechishin, Owen; Luchman, Artee; Kelly, John J.; Weiss, Samuel; Hamilton, Mark G.; Cairncross, Gregory; Senger, Donna L.; Bell, John; McFadden, Grant; Forsyth, Peter A.; Tzeng, Stephany Y.; Guerrero-Cazares, Hugo; Martinez, Elliott E.; Young, Noah P.; Sunshine, Joel C.; Quinones-Hinojosa, Alfredo; Green, Jordan J.; Lei, Liang; D'Amico, Randy; Sisti, Julia; Leung, Richard; Sonabend, Adam M.; Guarnieri, Paolo; Rosenfeld, Steven S.; Bruce, Jeffrey N.; Canoll, Peter; Baichwal, Vijay R.; Reeves, Leslie; Chad, Bradford L.; Zavitz, Kenton H.; Beelen, Andrew P.; Mather, Gary G.; Carlson, Robert O.; Manton, Christa; Chandra, Joya; Keir, Stephen T.; Reardon, David A.; Saling, Julia R.; Gray, Lloyd S.; Bigner, Darell D.; Friedman, Henry S.; Zhang, Jiqing; Brun, Jan; Ogbomo, Henry; Wang, Zhigang; Stojdl, David J.; Kong, Ling-Yuan; Hatiboglu, Mustafa A.; Wei, Jun; Wang, Yongtao; McEnery, Kayla A.; Fuller, Gregory N.; Qiao, Wei; Davies, Michael A.; Priebe, Waldemar; Heimberger, Amy B.; Amendolara, Benjamin; Gil, Orlando; Ivkovic, Sanja; Bruce, Jeffrey; Rosenfeld, Steven; Finniss, Susan; Perlstein, Benny; Miller, Cathie; Okhrimenko, Hana; Kazimirsky, Gila; Cazacu, Simona; Lemke, Nancy; Brodie, Shlomit; Rempel, Sandra A.; Rosenblum, Mark; Mikkelsen, Tom; Margel, Shlomo; Brodie, Chaya; Guvenc, Hacer; Demir, Habibe; Gupta, Snehalata; Mazumder, Sarmistha; Ray-Chaundhury, Abhik; Li, Tom; Li, Chenglong; Nakano, Ichiro; Rahman, Ruman; Rahman, Cheryl; Smith, Stuart; Macarthur, Donald; Rose, Felicity; Shakesheff, Kevin; Grundy, Richard G.; Brenner, Andrew J.; Goins, Beth; Bao, Ande; Miller, Jessica; Trevino, Abram; Zuniga, Richard; Phillips, William T.; Gilg, Anne G.; Bowers, Karen G.; Toole, Bryan P.; Maria, Bernard L.; Leung, Gilberto K.; Sun, Stella; Wong, Stanley T.; Zhang, Xiao Qin; Pu, Jenny K.; Lui, Wai Man; Marino, Anna M.; Hussaini, Isa M.; Amos, Samson; Simpson, Kendra; Redpath, Gerard T.; Lyons, Charles; Dipierro, Charles; Grant, Gerald A.; Wilson, Christy; Salami, Sara; Macaroni, Paolo; Li, Shuqin; Park, Ji-Young; Needham, David; Bigner, Darell; Dewhirst, Mark; Ohlfest, John; Gallardo, Jose; Argawal, Sagar; Mittapalli, Rajendar; Donelson, Randy; Elmquist, William F.; Nicolaides, Theodore; Hariono, Sujatmi; Barkovich, Krister; Hashizume, Rintaro; Rowitch, David; Weiss, William; Sheer, Denise; Baker, Suzanne; Paugh, Barbara; Waldman, Todd; Li, Huifang; Jones, Chris; Forshew, Tim; James, David; Caroline, Happold; Patrick, Roth; Katrin, Lamszus; Karl, Frei; Ghazaleh, Tabatabai; Michael, Weller; Albrecht, Valerie; Thorsteinsdottir, Jun; Wagner, Ernst; Tonn, Jörg-Christian; Ogris, Manfred; Schichor, Christian; Charest, Gabriel; Paquette, Benoit; Sanche, Léon; Mathieu, David; Fortin, David; Qi, Xiaoyang; Cuttitta, Franck; Chu, Zhengtao; Celerier, Jerome; Pakradouni, Jihane; Rixe, Olivier; Gragg, Ashley; Muller, Sabine; Banerjee, Anuradha; Phillips, Joanna; Prados, Michael; Haas-Kogan, Daphne; Gupta, Nalin; Florence, Lefranc; Gwendoline, Van Goietsenoven; Véronique, Mathieu; Robert, Kiss; Agarwal, Sagar; Mittapalli, Rajendar K.; Cen, Ling; Carlson, Brett L.; Sarkaria, Jann N.; Sengupta, Soma; Weeraratne, Shyamal D.; Rallapalli, Sundari; Amani, Vladimir; Pierre-Francois, Jessica; Teider, Natalia; Rotenberg, Alexander; Cook, James; Pomeroy, Scott L.; Jenses, Frances; Cho, Yoon-Jae; Hjouj, Mohammad; Last, David; Guez, David; Daniels, Dianne; Lavee, Jacob; Rubinsky, Boris; Mardor, Yael; Serwer, Laura P.; Noble, Charles O.; Michaud, Karine; Drummond, Daryl C.; Ozawa, Tomoko; Zhou, Yu; Marks, James D.; Bankiewicz, Krystof; Park, John W.; Wang, Weijun; Cho, Heeyeon; Weintraub, Michael; Jhaveri, Niyati; Torres, Shering; Petasis, Nicos; Schonthal, Axel H.; Louie, Stan G.; Hofman, Florence M.; Chen, Thomas C.; Grada, Zakaria; Hegde, Meenakshi; Schaffer, Donald R.; Ghazi, Alexia; Byrd, Tiara; Dotti, Gianpietro; Wels, Winfried; Heslop, Helen E.; Gottschalk, Stephen; Baker, Matthew; Ahmed, Nabil; Hamblett, Kevin J.; Kozlosky, Carl J.; Liu, Hua; Siu, Sophia; Arora, Taruna; Retter, Marc W.; Matsuda, Katherine; Hill, John S.; Fanslow, William C.; Diaz, Roberto J.; Etame, Arnold; Meaghan, O'Reilly; Mainprize, Todd; Smith, Christian; Hynynen, Kullervo; Rutka, James; Pradarelli, Jason; Yoo, Ji Young; Kaka, Azeem; Alvarez-Breckenridge, Christopher; Pan, Quintin; Chiocca, E. Antonio; Teknos, Theodoros; Kaur, Balveen; Lee, Sang Y.; Slagle-Webb, Becky; Sheehan, Jonas M.; Connor, James R.; Cote, Jerome; Lepage, Martin; Gobeil, Fernand; Kleijn, Anne; Balvers, Rutger; Kloezeman, Jenneke; Dirven, Clemens; Lamfers, Martine; Leenstra, Sieger; See, Wendy; Tan, I-Li; Pieper, Russell; Jiang, Hong; White, Erin; Ríos-Vicil, Christian I.; Yung, Wai-Kwan A.; Gomez-Manzano, Candelaria; Fueyo, Juan; Zemp, Franz J.; McKenzie, Brienne A.; Mueller, Sabine; Yang, Xiaodong; Smirnov, Ivan; Prados, Micheal; James, David C.; Phillips, Joanna J.; Berger, Mitchel S.; Rowitch, David H.; Haas-Kogan, Daphne H.; Kennedy, Benjamin; Gopalakrishnan, Vidya; Das, Chandramallika; Taylor, Pete; Kommagani, Ramakrishna; Su, Xiaohua; Aguilera, Dolly; Thomas, Alexandra; Wolff, Johannes; Flores, Elsa; Kadakia, Madhavi; Alkins, Ryan; Broderson, Peter; Sodhi, Rana; Chung, Sylvia A.; McDonald, Kerrie L.; Shen, Han; Day, Bryan W.; Stringer, Brett W.; Johns, Terrance; Decollogne, Stéphanie; Teo, Charlie; Hogg, Philip J.; Dilda, Pierre J.; Patel, Toral R.; Zhou, Jiangbing; Piepmeier, Joseph M.; Saltzman, W Mark; Vogelbaum, Michael A.; Manchanda, Pooja; Ohlfest, John R.; Kitange, Gaspar J.; Mladek, Ann C.; Schroeder, Mark A.; Pokorny, Jenny L.; Mody, Christopher; Forsyth, Peter; Dasgupta, Tina; James, C. David; Madhankumar, Achuthamangalam B.; Webb, Becky Slagle; Park, Annie; Harbaugh, Kimberly; Sheehan, Jonas |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2011 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
Abstracts |
| Description: |
BACKGROUND: Medulloblastoma is one of the most common malignant tumors of the central nervous system in newborn infants and children and accounts for about 15% to 20% of pediatric brain tumors. Despite current diagnostic and therapeutic advances, the morbidity and mortality rates still remain high. Furthermore, children who survive medulloblastoma are at risk for long-term sequelae related to the neurological effects of the tumor and surgery, radiotherapy, and chemotherapy. Therefore, it is of great importance to identify new anticancer drugs that can significantly assist in improving the survival of children with minimal or no side effects. In this study, our primary objective was to identify and study the efficacy of new structural classes of drugs belonging to a family of steroid biogenesis inhibitors and in the peroxovanadium superfamily. METHODS: We chose to undertake our preclinical testing on malignant pediatric medulloblastoma cell lines. After determining the IC50 values of our experimental drugs, we subjected our preclinical cell line models to a wide variety of cancer assays, including viability/proliferation, cell death, cell cycle regulation and transformation assays. RESULTS AND CONCLUSIONS: Our data so far demonstrate that the panel of new structural classes of drugs examined can significantly affect the viability and transformation of malignant medulloblastoma preclinical cell line models. Most importantly, the toxicity of our drugs was almost devoid in our non-transformed control cell lines. Our current work continues to explore the efficacy of these drugs in additional malignant medulloblastoma preclinical models. This body of work is novel and highly significant in our effort to discover improved treatments for childhood brain tumors. |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://neuro-oncology.oxfordjournals.org/cgi/content/short/13/suppl_3/iii107; http://dx.doi.org/10.1093/neuonc/nor158 |
| DOI: |
10.1093/neuonc/nor158 |
| Availability: |
http://neuro-oncology.oxfordjournals.org/cgi/content/short/13/suppl_3/iii107; https://doi.org/10.1093/neuonc/nor158 |
| Rights: |
Copyright (C) 2011, Society for Neuro-Oncology (SNO) |
| Accession Number: |
edsbas.EAFC7173 |
| Database: |
BASE |