| Title: |
Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children |
| Authors: |
Bastard, Paul; Gervais, Adrian; Taniguchi, Maki; Saare, Liisa; Särekannu, Karita; Le Voyer, Tom; Philippot, Quentin; Rosain, Jérémie; Bizien, Lucy; Asano, Takaki; Garcia-Prat, Marina; Parra-Martínez, Alba; Migaud, Mélanie; Tsumura, Miyuki; Conti, Francesca; Belot, Alexandre; Rivière, Jacques, G; Morio, Tomohiro; Tanaka, Junko; Javouhey, Etienne; Haerynck, Filomeen; Duvlis, Sotirija; Ozcelik, Tayfun; Keles, Sevgi; Tandjaoui-Lambiotte, Yacine; Escoda, Simon; Husain, Maya; Pan-Hammarström, Qiang; Hammarström, Lennart; Ahlijah, Gloria; Abi Haidar, Anthony; Soudee, Camille; Arseguel, Vincent; Abolhassani, Hassan; Sahanic, Sabina; Tancevski, Ivan; Nukui, Yoko; Hayakawa, Seiichi; Chrousos, George, P; Michos, Athanasios; Tatsi, Elizabeth-Barbara; Filippatos, Filippos; Rodriguez-Palmero, Agusti; Troya, Jesus; Tipu, Imran; Meyts, Isabelle; Roussel, Lucie; Ostrowski, Sisse Rye; Schidlowski, Laire; Prando, Carolina; Condino-Neto, Antonio; Cheikh, Nathalie; Bousfiha, Ahmed, A; El Bakkouri, Jalila; Aguilera-Albesa, Sergio; Alkhater, Suzan, A; Alkan, Gulsum; Castagnoli, Riccardo; Cyrus, Cyril; Elmas Bozdemir, Sefika; Emiroglu, Melike; Gulhan, Belgin; Erdeniz, Emine Hafize; Hatipoglu, Nevin; Bayhan, Gülsün Iclal; Jabandziev, Petr; Kanik Yuksek, Saliha; Karbuz, Adem; Tüter Öz, Şadiye Kübra; Marseglia, Gian Luigi; Metin Akcan, Ozge; Kılıç, Ahmet Osman; Ozkaya Parlakay, Aslinur; Papadaki, Maria; Slaba, Katerina; Sevketoglu, Esra; Valencia-Ramos, Juan; Yahşi, Aysun; Aguilera Guirao, Antonio; Álvarez Escudero, Julián; Antela López, Antonio; Barbeito Castiñeiras, Gema; Bello Paderne, Xabier; Ben García, Miriam; Carral García, María Victoria; Cebey López, Miriam; Coira Nieto, Amparo; Conde Pájaro, Mónica; Costa Alcalde, José Javier; Currás Tuala, María José; Dacosta Urbieta, Ana Isabel; Díaz Esteban, Blanca; Domínguez Santalla, María Jesús; Fernández Pérez, Cristina; Fernández Villaverde, Juan; Galbán Rodríguez, Cristóbal; García Allut, José Luis; García Vicente, Luisa; Giráldez Vázquez, Elena; Gómez Carballa, Alberto; Gómez Rial, José; González Barcala, Francisco Javier; Guerra Liñares, Beatriz; Leboráns Iglesias, Pilar; Lence Massa, Beatriz; Lendoiro Fuentes, Marta; López Franco, Montserrat; López Lago, Ana; Martinón-Torres, Federico; Salas, Antonio; Navarro de la Cruz, Daniel; Núñez Masid, Eloína; Ortolá Devesa, Juan Bautista; Pardo Seco, Jacobo; Pazo Núñez, María; Pérez del Molino Bernal, Marisa; Pérez Freixo, Hugo; Piñeiro Rodríguez, Lidia; Pischedda, Sara; Portela Romero, Manuel; Pose Reino, Antonio; Prada Hervella, Gloria María; Queiro Verdes, Teresa; Redondo Collazo, Lorenzo; Regueiro Casuso, Patricia; Rey García, Susana; Rey Vázquez, Sara; Riveiro Blanco, Vanessa; Rivero Calle, Irene; Rivero Velasco, Carmen; Rodríguez Núñez, Nuria; Rodríguez-Tenreiro Sánchez, Carmen; Saborido Paz, Eva; Sadiki Orayyou, José Miguel; Saito Villanueva, Carla; Serén Fernández, Sonia; Souto Sanmartín, Pablo; Taboada Muñiz, Manuel; Trastoy Pena, Rocío; Treviño Castellano, Mercedes; Valdés Cuadrado, Luis; Varela García, Pablo; Vilas Iglesias, María Soledad; Viz Lasheras, Sandra; Ferreiro-Iglesias, Rocio; Bastón-Rey, Iria; Calviño-Suárez, Cristina; Abel, Laurent; Aiuti, Alessandro; Al-Muhsen, Saleh; Al-Mulla, Fahd; Amara, Ali; Anderson, Mark, S; Andreakos, Evangelos; Arias, Andrés, A; Arkin, Lisa, M; Baris Feldman, Hagit; Biggs, Catherine, M; Bogunovic, Dusan; Bolze, Alexandre; Bondarenko, Anastasiia; Brodin, Petter; Bryceson, Yenan; Butte, Manish, J; Casanova, Jean-Laurent; Casari, Giorgio; Christodoulou, John; Cobat, Aurélie; Colobran, Roger; Constantinescu, Stefan, N; Cooper, Megan, A; Dalgard, Clifton, L; Desai, Murkesh; Drolet, Beth, A; Duval, Xavier; El Baghdadi, Jamila; Eloy, Philippine; Espinosa-Padilla, Sara; Fellay, Jacques; Flores, Carlos; Franco, José Luis; Froidure, Antoine; Gorochov, Guy; Gregersen, Peter, K; Grimbacher, Bodo; Hagin, David; Halwani, Rabih; Heath, James, R; Hsieh, Elena W.Y.; Husebye, Eystein; Imai, Kohsuke; Itan, Yuval; Jarvis, Erich, D; Jouanguy, Emmanuelle; Kaja, Elżbieta; Karamitros, Timokratis; Kisand, Kai; Ku, Cheng-Lung; Lau, Yu-Lung; Ling, Yun; Lucas, Carrie, L; Mansouri, Davood; Maródi, László; Mentré, France; Milner, Joshua, D; Mironska, Kristina; Mogensen, Trine, H; Ng, Lisa F.P.; Notarangelo, Luigi, D; Novelli, Antonio; Novelli, Giuseppe; O’Farrelly, Cliona; Okada, Satoshi; Okamoto, Keisuke; Pape, Jean, W; Perez de Diego, Rebeca; Perez-Tur, Jordi; Perlin, David, S; Pesole, Graziano; Planas, Anna, M; Pujol, Aurora; Puel, Anne; Quintana-Murci, Lluis; Ramaswamy, Sathishkumar; Renia, Laurent; Resnick, Igor; Rodríguez-Gallego, Carlos; Sancho-Shimizu, Vanessa; Sediva, Anna; Seppänen, Mikko R.J.; Shahrooei, Mohammed; Shcherbina, Anna; Slaby, Ondrej; Snow, Andrew, L; Soler-Palacín, Pere; Soumelis, Vassili; Spaan, András, N; Su, Helen, C; Tangye, Stuart, G; Abou Tayoun, Ahmad; Temel, Şehime Gülsün; Thorball, Christian; Tiberghien, Pierre; Trouillet-Assant, Sophie; Turvey, Stuart, E; Furkan Uddin, K.M.; Uddin, Mohammed, J; van de Beek, Diederik; Vinh, Donald, C; von Bernuth, Horst; Wauters, Joost; Zatz, Mayana; Zawadzki, Pawel; Zhang, Qian; Zhang, Shen-Ying; Peterson, Pärt; Lévy, Romain; Quartier, Pierre; Boisson, Bertrand; Béziat, Vivien; Borghesi, Alessandro; Pession, Andrea; Marr, Nico; Mentis, Alexios-Fotios A; Tillmann, Vallo; Neven, Bénédicte; Gómez-Carballa, Alberto; Gonzalez-Granado, Luis, I |
| Contributors: |
Human genetics of infectious diseases : Mendelian predisposition (Equipe Inserm U1163); Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité); Activation et transduction du signal dans les lymphocytes - Lymphocyte activation and signaling CIRI (CIRI-LYACTS); Centre International de Recherche en Infectiologie (CIRI); École normale supérieure de Lyon (ENS de Lyon); Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon); Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Hospices Civils de Lyon (HCL); Virology and human respiratory Pathologies - Virology and human respiratory Pathologies CIRI (CIRI-VirPath); ANR-22-CE15-0046,AI2D,Autoanticorps anti-interférons et maladies infectieuses associées(2022); ANR-21-LIBA-0002,AAILC,Autoanticorps contre les interférons de type I chez les patients libanais hospitalisés pour COVID-19.(2021); ANR-20-CE93-0003,GENVIR,Analyse multi-omique de l'immunité anti-virale: de l'identification des circuits biologiques pertinents à la découverte de défauts monogéniques héréditaires de l'immunité chez les patients avec infections virales sévères(2020); ANR-10-IAHU-0001,Imagine,Institut Hospitalo-Universitaire Imagine(2010); ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010); ANR-21-RHUS-0008,COVIFERON,Covid-19 and interferons: from discovery to therapy(2021); European Project: 101057100,HORIZON-HLTH-2021-DISEASE-04,HORIZON-HLTH-2021-DISEASE-04,UNDINE(2022) |
| Source: |
ISSN: 0022-1007. |
| Publisher Information: |
CCSD; Rockefeller University Press |
| Publication Year: |
2024 |
| Collection: |
Université Jean Monnet – Saint-Etienne: HAL |
| Subject Terms: |
[SDV]Life Sciences [q-bio] |
| Description: |
International audience ; We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7–9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2–5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6–35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1–9.6]) of IFN-ω and/or IFN-α2. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/grantAgreement//101057100/EU/The human genetic and immunological determinants of the clinical manifestations of SARS-CoV-2 infection: Towards personalised medicine/UNDINE |
| DOI: |
10.1084/jem.20231353 |
| Availability: |
https://hal.science/hal-04815875; https://hal.science/hal-04815875v1/document; https://hal.science/hal-04815875v1/file/JEM_20231353.pdf; https://doi.org/10.1084/jem.20231353 |
| Rights: |
http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.EB569556 |
| Database: |
BASE |