| Title: |
Resting-State Functional Connectivity in Frontostriatal and Posterior Cortical Subtypes in Parkinson's Disease-Mild Cognitive Impairment. |
| Authors: |
Devignes, Quentin; Bordier, Cecile; Viard, Romain; Defebvre, Luc; Kuchcinski, Gregory; Leentjens, A. F. G.; Lopes, Renaud; Dujardin, Kathy |
| Contributors: |
Lille Neurosciences & Cognition - U 1172 LilNCog; Lille in vivo imaging and Functional Exploration - PLBS LiiFE; Lille Neurosciences & Cognition (LilNCog) - U 1172 |
| Publication Year: |
2024 |
| Collection: |
LillOA (Lille Open Archive - Université de Lille) |
| Subject Terms: |
cognition; independent component analysis; cognitive subtypes; dual syndrome hypothesis |
| Description: |
Background The “dual syndrome hypothesis” distinguished two subtypes in mild cognitive impairment (MCI) in Parkinson's disease: frontostriatal, characterized by attentional and executive deficits; and posterior cortical, characterized by visuospatial, memory, and language deficits. Objective The aim was to identify resting-state functional modifications associated with these subtypes. Methods Ninety-five nondemented patients categorized as having normal cognition (n = 31), frontostriatal (n = 14), posterior cortical (n = 20), or mixed (n = 30) cognitive subtype had a 3 T resting-state functional magnetic resonance imaging scan. Twenty-four age-matched healthy controls (HCs) were also included. A group-level independent component analysis was performed to identify resting-state networks, and the selected components were subdivided into 564 cortical regions in addition to 26 basal ganglia regions. Global intra- and inter-network connectivity along with global and local efficiencies was compared between groups. The network-based statistics approach was used to identify connections significantly different between groups. ; 37;3 |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/octet-stream |
| Language: |
English |
| Relation: |
MOVEMENT DISORDERS; Mov Disord; http://hdl.handle.net/20.500.12210/95744 |
| Availability: |
https://hdl.handle.net/20.500.12210/95744 |
| Accession Number: |
edsbas.EB64D61B |
| Database: |
BASE |