| Title: |
Equine trypanosomiasis, a systematic review and meta‐analyses: prevalence, morbidity and mortality |
| Authors: |
Raftery, Alexandra G.; Gummery, Lauren; Garcia, Karelhia; Mohite, Dinesh; Capewell, Paul; Sutton, David G.M. |
| Publisher Information: |
Wiley |
| Publication Year: |
2025 |
| Collection: |
University of Glasgow: Enlighten - Publications |
| Description: |
Background: Equine trypanosomiasis is a neglected protozoal disease. Objectives: To perform a systematic search of literature to explore: (1) In equines what is the global geographical distribution and prevalence of trypanosomiasis? In low and middle-income countries (LMICs) is trypanosomiasis more prevalent than in higher-income countries (HICs)? (2) Is trypanosomiasis infection a significant contributor to global morbidity and mortality? Study Design: Systematic review and meta-analyses. Methods: Studies were identified that described naturally occurring equine trypanosomiasis worldwide following ‘Preferred Reporting Items for Systematic Reviews and Meta-Analyses’ using eight international databases (1980–2022). Equine population data for each country were extracted. Meta-analyses were used to estimate point prevalence and disease characteristics. Country exposure risk to equines (negligible/low/medium/high) and clinical data (Trypanosoma sp.; outbreak (O) vs. endemic (E) disease) were categorised. Results: Study quality was assessed (Question 1 prevalence: n = 147 manuscripts, median grade ‘medium’ (4/8 (range 2–6)); Question 2 morbidity and mortality: n = 46 ‘moderate’ (n = 1), ‘low’ (n = 20) or ‘very low’ (n = 25)). Heterogeneity was high. LMICs were more likely to report disease (41/125; 33% vs. 7/80, 9%; (p < 0.001; OR 5.1 (2.1–14.2))). Fifty-six percent of the world's equines reside in a ‘medium’/‘high’ risk country (61,507,601). Disease characteristics were summated. For Trypanosoma evansi: (O) Infection rate (IR) (42%; 95% CI 14–76), morbidity (47%; (13–85)), mortality (23%; 7–54) and death to case ratio (DCR) (45%; 20–73). Trypanosoma equiperdum: (O) IR 12% (7–18), morbidity 25% (9–49). Tsetse transmitted trypanosomiasis (O): IR 46% (29–63), morbidity 46% (29%–63%), mortality 6% (1–19), DCR 12% (2–38). (E) IR 50% (20–60), morbidity (no data), mortality 11% (7–14), DCR 9% (5–16). Trypanosoma vivax (O) IR 43% (10–83), morbidity 43% (10–83), mortality 15% (0–100), DCR 32% (0–100). Main Limitations: ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://eprints.gla.ac.uk/369560/1/369560.pdf; Raftery, Alexandra G. , Gummery, Lauren , Garcia, Karelhia, Mohite, Dinesh, Capewell, Paul ORCID logoorcid:0000-0002-8803-5034 and Sutton, David G.M. ORCID logoorcid:0000-0002-7241-8444 (2025) Equine trypanosomiasis, a systematic review and meta‐analyses: prevalence, morbidity and mortality. Equine Veterinary Journal , (doi:10.1111/evj.70101 ) (Early Online Publication) |
| DOI: |
10.1111/evj.70101 |
| Availability: |
https://eprints.gla.ac.uk/369560/; https://eprints.gla.ac.uk/369560/1/369560.pdf; https://doi.org/10.1111/evj.70101 |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.EB713633 |
| Database: |
BASE |