| Title: |
hUNC‐93B1, a novel gene mainly expressed in the heart, is related to left ventricular diastolic function, heart failure morbidity and mortality in elderly men |
| Authors: |
Ärnlöv, Johan; Sundström, Johan; Lind, Lars; Andrén, Bertil; Andersson, Maria; Reneland, Richard; Berglund, Lars; Kashuba, Vladimir; Protopopov, Alexei; Zabarovsky, Eugene; Lithell, Hans |
| Source: |
European Journal of Heart Failure ; volume 7, issue 6, page 958-965 ; ISSN 1388-9842 1879-0844 |
| Publisher Information: |
Wiley |
| Publication Year: |
2005 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Aims: The hUNC‐93B1 gene has the highest expression in the heart. We aimed to explore relationships between the hUNC‐93B1 gene and cardiac function, morbidity and mortality in elderly men. Methods and results: Two sub‐samples of the population‐based ULSAM‐cohort ( n =330, mean age 71 years and n =152, mean age 75 years, respectively) were used to explore and validate relationships between genotypes of the hUNC‐93B1 gene and cardiac phenotypes (ejection fraction, E/A‐ratio, left ventricular mass index and relative wall thickness). In the two samples, subjects homozygous for haplotype H3 had 34% and 35% higher level of E/A‐ratio compared to non‐carriers ( p =0.0002 and 0.017, respectively) independent of cardiovascular disease and medication. Using national cause‐of‐death and hospital‐discharge register data with 29 years of follow‐up, no heart failure patients homozygous for haplotype H3 were hospitalised for heart failure before the age of 75 years, compared to 25% for heterozygous and 55% for non‐carriers ( p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1016/j.ejheart.2004.06.009 |
| Availability: |
https://doi.org/10.1016/j.ejheart.2004.06.009; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2Fj.ejheart.2004.06.009; https://onlinelibrary.wiley.com/doi/pdf/10.1016/j.ejheart.2004.06.009 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.EB81F441 |
| Database: |
BASE |