| Title: |
Impact of Human Immunodeficiency Virus Type 1 Minority Variants on the Virus Response to a Rilpivirine-Based First-line Regimen |
| Authors: |
Raymond, Stéphanie; Nicot, Florence; Pallier, Coralie; Bellecave, Pantxika; Maillard, Anne; Trabaud, Mary Anne; Morand-Joubert, Laurence; Rodallec, Audrey; Amiel, Corinne; Mourez, Thomas; Bocket, Laurence; Beby-Defaux, Agnès; Bouvier-Alias, Magali; Lambert-Niclot, Sidonie; Charpentier, Charlotte; Malve, Brice; Mirand, Audrey; Dina, Julia; Le Guillou-Guillemette, Hélène; Marque-Juillet, Stéphanie; Signori-Schmuck, Anne; Barin, Francis; Si-Mohamed, Ali; Fenoel, Véronique Avettand; Roussel, Catherine; Calvez, Vincent; Saune, Karine; Marcelin, Anne Geneviève; Rodriguez, Christophe; Descamps, Diane; Izopet, Jacques; Lagier, E; Roussel, C; Le Guillou-Guillemette, H; Alloui, C; Bettinger, D; Pallier, C; Fleury, H; Reigadas, S; Bellecave, P; Recordon-Pinson, P; Payan, C; Vallet, S; Vabret, A; Dina, J; Henquell, C; Mirand, A; Bouvier-Alias, M; de Rougemont, A; Dos Santos, G; Morand, P; Signori-Schmuck, A; Bocket, L; Rogez, S; Andre, P; Tardy, JC; Trabaud, MA; Tamalet, C; Delamare, C; Montes, B; Schvoerer, E; Ferré, V; André-Garnier, E; Cottalorda, J; Guinard, J; Guiguon, A; Descamps, D; Brun-Vézinet, F; Charpentier, C; Visseaux, B; Peytavin, G; Krivine, A; Si-Mohamed, A; Avettand-Fenoel, V; Marcelin, AG; Calvez, V; Lambert-Niclot, S; Soulié, C; Wirden, M; Morand-Joubert, L; Delaugerre, C; Chaix, ML; Amiel, C; Schneider, V; Giraudeau, G; Defaux, A Beby-; Brodard, V; Maillard, A; Plantier, JC; Chaplain, C; Bourlet, T; Fafi-Kremer, S; Stoll-Keller, F; Schmitt, MP; Barth, H; Yerly, S; Poggi, C; Izopet, J; Raymond, S; Barin, F |
| Source: |
Clinical Infectious Diseases, vol 66, iss 10 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2018 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
3207 Medical Microbiology (for-2020); 32 Biomedical and Clinical Sciences (for-2020); 3202 Clinical Sciences (for-2020); 3204 Immunology (for-2020); HIV/AIDS (rcdc); Genetics (rcdc); Infectious Diseases (rcdc); Antimicrobial Resistance (rcdc); 2.1 Biological and endogenous factors (hrcs-rac); Infection (hrcs-hc); 3 Good Health and Well Being (sdg); Adult (mesh); Drug Resistance; Viral (mesh); Female (mesh); Genetic Variation (mesh); HIV Infections (mesh); HIV-1 (mesh); Humans (mesh); Male (mesh); Mutation (mesh); Rilpivirine (mesh); Viral Load (mesh); minority resistant variants; rilpivirine; first-line antiretroviral therapy; ultra-deep sequencing; French National Agency for Research on AIDS and Viral Hepatitis (ANRS) AC11 Resistance Study Group |
| Time: |
1588 - 1594 |
| Description: |
Background: Minority resistant variants of human immunodeficiency virus type 1 (HIV-1) could influence the virological response to treatment based on nonnucleoside reverse transcriptase inhibitors (NNRTIs). Data on minority rilpivirine-resistant variants are scarce. This study used next-generation sequencing (NGS) to identify patients harboring minority resistant variants to nucleos(t)ide reverse transcriptase inhibitors and NNRTIs and to assess their influence on the virological response (VR). Methods: All the subjects, 541 HIV-1-infected patients started a first-line regimen containing rilpivirine. VR was defined as a HIV-1 RNA load |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt24v7c6qb; https://escholarship.org/uc/item/24v7c6qb; https://escholarship.org/content/qt24v7c6qb/qt24v7c6qb.pdf |
| DOI: |
10.1093/cid/cix1070 |
| Availability: |
https://escholarship.org/uc/item/24v7c6qb; https://escholarship.org/content/qt24v7c6qb/qt24v7c6qb.pdf; https://doi.org/10.1093/cid/cix1070 |
| Rights: |
public |
| Accession Number: |
edsbas.EBA5B0E4 |
| Database: |
BASE |