| Title: |
Remdesivir for the Treatment of Human Coronavirus OC43 Encephalitis |
| Authors: |
Fourgeaud, Jacques; Turlure, Pascal; Dupont, Marine; Veyrenche, Nicolas; Busquet, Clémence; Alain, Sophie; Leruez-Ville, Marianne; Dheilly, Nolwenn, M.; Frange, Pierre |
| Contributors: |
Fédération pour la recherche en explorations et thérapeutiques innovantes in utéro (FETUS (URP 7328)); Université Paris Cité (UPCité); Hôpital Necker - Enfants Malades AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); CHU Limoges; Découverte de pathogènes – Pathogen discovery; Institut Pasteur Paris (IP)-Université Paris Cité (UPCité) |
| Source: |
ISSN: 0146-6615. |
| Publisher Information: |
CCSD; Wiley-Blackwell |
| Publication Year: |
2025 |
| Subject Terms: |
encephalitis; human coronavirus OC43; immunodeficiency; remdesivir; [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases; [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology |
| Description: |
International audience ; Human coronavirus OC43 (HCoV‐OC43) is predominantly associated with mild respiratory infections. HCoV‐OC43 also has neuroinvasive properties, and severe encephalitis has been described in immunocompromised patients, with fatal outcomes due to the lack of specific antiviral treatment. We report a case of severe febrile encephalitis attributed to HCoV‐OC43 that progressively worsened over 3 months in a 65‐year‐old immunocompromised man. Clinical symptoms improved remarkably after treatment with remdesivir, with an increase of the Glasgow Coma Score from 8 to 14 within 7 days. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40108967; PUBMED: 40108967; PUBMEDCENTRAL: PMC11923506 |
| DOI: |
10.1002/jmv.70314 |
| Availability: |
https://pasteur.hal.science/pasteur-05117039; https://pasteur.hal.science/pasteur-05117039v1/document; https://pasteur.hal.science/pasteur-05117039v1/file/Journal%20of%20Medical%20Virology%20-%202025%20-%20Fourgeaud%20-%20Remdesivir%20for%20the%20Treatment%20of%20Human%20Coronavirus%20OC43%20Encephalitis.pdf; https://doi.org/10.1002/jmv.70314 |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.EBA63C07 |
| Database: |
BASE |