| Title: |
Heterogeneity and Penumbra of White Matter Hyperintensities in Small Vessel Diseases Determined by Quantitative MRI |
| Authors: |
Voorter, Paulien H M; Stringer, Michael S; van Dinther, Maud; Kerkhofs, Daniëlle; Dewenter, Anna; Blair, Gordon W; Thrippleton, Michael J; Jaime Garcia, Daniela; Chappell, Francesca M; Janssen, Esther; Kopczak, Anna; Staals, Julie; Ingrisch, Michael; Duering, Marco; Doubal, Fergus N; Dichgans, Martin; van Oostenbrugge, Robert J; Jansen, Jacobus F A; Wardlaw, Joanna M; Backes, Walter H |
| Source: |
Voorter, P H M, Stringer, M S, van Dinther, M, Kerkhofs, D, Dewenter, A, Blair, G W, Thrippleton, M J, Jaime Garcia, D, Chappell, F M, Janssen, E, Kopczak, A, Staals, J, Ingrisch, M, Duering, M, Doubal, F N, Dichgans, M, van Oostenbrugge, R J, Jansen, J F A, Wardlaw, J M, Backes, W H & SVDs@target Consortium 2025, 'Heterogeneity and Penumbra of White Matter Hyperintensities in Small Vessel Diseases Determined by Quantitative MRI', Stroke, vol. 56, no. 1, pp. 128-137. https://doi.org/10.1161/STROKEAHA.124.047910 |
| Publication Year: |
2025 |
| Collection: |
Maastricht University Research Publications |
| Subject Terms: |
blood-brain barrier; cerebral small vessel diseases; diffusion; magnetic resonance imaging; perfusion |
| Description: |
BACKGROUND: White matter hyperintensities (WMHs) are established structural imaging markers of cerebral small vessel disease. The pathophysiologic condition of brain tissue varies over the core, the vicinity, and the subtypes of WMH and cannot be interpreted from conventional magnetic resonance imaging. We aim to improve our pathophysiologic understanding of WMHs and the adjacently injured normal-appearing white matter in terms of microstructural and microvascular alterations using quantitative magnetic resonance imaging in patients with sporadic and genetic cerebral small vessel disease. METHODS: Structural T2-weighted imaging, multishell diffusion imaging, and dynamic contrast-enhanced magnetic resonance imaging were performed at 3T in 44 participants with sporadic cerebral small vessel disease and 32 participants with monogenic cerebral small vessel disease (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy; 59±12 years, 41 males) between June 2017 and May 2020 as part of the prospective, multicenter (Edinburgh, the United Kingdom; Maastricht, the Netherlands; and Munich, Germany), observational INVESTIGATE-SVDs study (Imaging Neurovascular, Endothelial and Structural Integrity in Preparation to Treat Small Vessel Diseases). The mean diffusivity, free water content, and perfusion (all derived from multishell diffusion imaging), as well as the blood-brain barrier leakage and plasma volume fraction (derived from dynamic contrast-enhanced magnetic resonance imaging), were compared between deep and periventricular WMH types using paired t tests. Additional spatial analyses were performed inside and outside the WMH types to determine the internal heterogeneity and the extent of the penumbras, that is, adjacent white matter at risk for conversion to WMH. RESULTS: Periventricular WMH had higher mean diffusivity, higher free water content, and more plasma volume compared with deep WMH (P |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
0039-2499; 1524-4628 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pissn/0039-2499; info:eu-repo/semantics/altIdentifier/eissn/1524-4628 |
| DOI: |
10.1161/STROKEAHA.124.047910 |
| Availability: |
https://cris.maastrichtuniversity.nl/en/publications/e1391766-aa8a-41ab-95c6-02810582a8af; https://doi.org/10.1161/STROKEAHA.124.047910; https://cris.maastrichtuniversity.nl/ws/files/235274296/Dinther-2024-Heterogeneity-and-Penumbra-of-White-Matter.pdf |
| Rights: |
info:eu-repo/semantics/openAccess ; https://umlib.nl/taverne-license |
| Accession Number: |
edsbas.EBBC5F5F |
| Database: |
BASE |