| Title: |
Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study |
| Authors: |
van der Ende, EL; Heller, C; Sogorb-Esteve, A; Swift, IJ; McFall, D; Peakman, G; Bouzigues, A; Poos, JM; Jiskoot, LC; Panman, JL; Papma, JM; Meeter, LH; Dopper, EGP; Bocchetta, M; Todd, E; Cash, D; Graff, C; Synofzik, M; Moreno, F; Finger, E; Sanchez-Valle, R; Vandenberghe, R; Laforce, R; Masellis, M; Tartaglia, MC; Rowe, JB; Butler, C; Ducharme, S; Gerhard, A; Danek, A; Levin, J; Pijnenburg, YAL; Otto, M; Borroni, B; Tagliavini, F; de Mendonça, A; Santana, I; Galimberti, D; Sorbi, S; Zetterberg, H; Huang, E; van Swieten, JC; Rohrer, JD; Seelaar, H; Afonso, S; Almeida, MR; Anderl-Straub, S; Andersson, C; Antonell, A; Archetti, S; Arighi, A; Balasa, M; Barandiaran, M; Bargalló, N; Bartha, R; Bender, B; Benussi, A; Benussi, L; Bessi, V; Binetti, G; Black, S; Borrego-Ecija, S; Bras, J; Bruffaerts, R; Cañada, M; Cantoni, V; Caroppo, P; Castelo-Branco, M; Convery, R; Cope, T; Di Fede, G; Díez, A; Duro, D; Fenoglio, C; Ferrari, C; Ferreira, CB; Fox, N; Freedman, M; Fumagalli, G; Gabilondo, A; Gasparotti, R; Gauthier, S; Gazzina, S; Giaccone, G; Gorostidi, A; Greaves, C; Guerreiro, R; Hoegen, T; Indakoetxea, B; Jelic, V; Karnath, HO; Keren, R; Langheinrich, T; Leitão, MJ; Lladó, A; Lombardi, G; Loosli, S; Maruta, C; Mead, S |
| Publisher Information: |
BioMed Central (part of Springer Nature) |
| Publication Year: |
2022 |
| Collection: |
Brunel University London: Brunel University Research Archive (BURA) |
| Subject Terms: |
biomarker; complement; frontotemporal dementia; neuroinflammation |
| Description: |
Availability of data and materials: The raw data of this project are part of GENFI. De-identified patient data can be accessed upon reasonable request to genfi@ucl.ac.uk. ; Several authors of this publication are members of the European Reference Network for Rare Neurological Diseases—Project ID no. 739510. ; Supplementary Information: Additional file 1 of Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study. Available at: https://static-content.springer.com/esm/art%3A10.1186%2Fs12974-022-02573-0/MediaObjects/12974_2022_2573_MOESM1_ESM.pdf. Additional file 1: Table S1. Number of samples for each of the analytes in CSF and plasma. Table S2. Correlations between complement proteins and age. Table S3. Correlations between grey matter volume and (a) CSF and (b) plasma complement protein concentration. Table S4. Correlations between clinical measures of disease severity and (a) CSF and (b) plasma complement proteins. Table S5. Correlations between plasma complement factors. Table S6. Correlations between plasma complement proteins, neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP). Table S7. Complement protein levels of seven presymptomatic carriers who became symptomatic during follow-up (‘converters’). Figure S1. Correlations between CSF C1q, C3b and disease duration. P-values were derived from Spearman’s rho. ; Copyright © The Author(s) 2022. Background: Neuroinflammation is emerging as an important pathological process in frontotemporal dementia (FTD), but biomarkers are lacking. We aimed to determine the value of complement proteins, which are key components of innate immunity, as biomarkers in cerebrospinal fluid (CSF) and plasma of presymptomatic and symptomatic genetic FTD mutation carriers. Methods: We measured the complement proteins C1q and C3b in CSF by ELISAs in 224 presymptomatic and symptomatic GRN, C9orf72 or MAPT mutation carriers and non-carriers participating in the Genetic Frontotemporal Dementia Initiative (GENFI), a ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
1 - 13; Electronic |
| Language: |
English |
| Relation: |
Journal of Neuroinflammation; 217; https://bura.brunel.ac.uk/handle/2438/25682 |
| DOI: |
10.1186/s12974-022-02573-0 |
| Availability: |
https://bura.brunel.ac.uk/handle/2438/25682; https://doi.org/10.1186/s12974-022-02573-0 |
| Rights: |
Copyright © The Author(s) 2022. Rights and permissions: Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. ; https://creativecommons.org/licenses/by/4.0/ ; The Author(s) |
| Accession Number: |
edsbas.EBD938BF |
| Database: |
BASE |