| Title: |
A ketogenic diet enhances aerobic exercise adaptation and promotes muscle mitochondrial remodeling in hyperglycemic male mice |
| Authors: |
Pattamaprapanont, Pattarawan; Nava, Roberto C.; Grover, Rea; Formato, Mia; Cooney, Eileen M.; Pinto, Ana Paula; Alves-Wagner, Ana B.; Das, Anamica; Guan, Yuntian; Annambhotla, Meghana; Acharya, Saanvi; Rivas, Donato A.; Lessard, Sarah J. |
| Publication Year: |
2025 |
| Collection: |
VTechWorks (VirginiaTech) |
| Description: |
VO 2 peak is a key health benefit of aerobic exercise; however, chronic hyperglycemia is associated with persistently low VO 2 peak due to an impaired adaptive response to training. Here, we show that reducing blood glucose with a carbohydrate-restricted, high fat ketogenic diet can restore aerobic exercise adaptation in male mice with hyperglycemia. Hyperglycemic mice received standard high-carbohydrate chow (CHOW), which sustains high blood glucose; or a ketogenic diet (KETO), which normalizes blood glucose levels. After aerobic exercise training, improvements in VO 2 peak are blunted in CHOW, but restored by KETO. Increased VO 2 peak in KETO is associated with enhanced aerobic remodeling of skeletal muscle, including a more oxidative fiber-type and increased capillary density. Moreover, KETO induces exercise-independent effects on muscle mitochondrial remodeling and substrate selection, significantly increasing fatty acid oxidation and down-regulating glucose metabolism. We identify a ketogenic diet as a potential therapy to improve aerobic exercise adaptation in the growing population with hyperglycemia. ; Published version |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://hdl.handle.net/10919/141584 |
| DOI: |
10.21203/rs.3.rs-5814971/v1 |
| Availability: |
https://hdl.handle.net/10919/141584; https://doi.org/10.21203/rs.3.rs-5814971/v1 |
| Rights: |
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International ; http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.EC3D7607 |
| Database: |
BASE |