| Title: |
Ocrelizumab versus interferon beta-1a in relapsing multiple sclerosis |
| Authors: |
Hauser, S; Bar Or, A; Comi, G; Giovannoni, G; Hartung, H; Hemmer, B; Lublin, F; Montalban, X; Rammohan, K; Selmaj, K; Traboulsee, A; Wolinsky, J; Arnold, D; Klingelschmitt, G; Masterman, D; Fontoura, P; Belachew, S; Chin, P; Mairon, N; Garren, H; Kappos, L; Reingold, S; Sandberg Wollheim, M; Barkhof, F; Dörmer, T; Evans, S; Mcfarland, H; Steiner, I; Yaldizli, O; D’Souza, M; Andelova, M; Rust, H; Ballario, C; Giannaula, R; Reich, E; Parratt, J; Eggers, C; Buyle, M; Van Pesch, V; Vanopdenbosch, L; Carneiro, D; Friedrich, M; Longo, A; Genov, K; Ivanova, S; Maslarov, D; Lilovski, H; Staikov, I; Cueto, G; Dufek, M; Havrdova, E; Novotna, A; Skoda, O; Talabova, M; Vachova, M; Gross Paju, K; Haldre, S; Elovaara, I; Brochet, B; Castelnovo, G; Clavelou, P; De Seze, J; Debouverie, M; Braune, S; Haas, J; Heidenreich, F; Schwarz, W; Siever, A; Urban, P; Zettl, U; Ziemann, U; Ziemssen, T; Zipp, F; Debreczeni, R; Rozsa, C; Satori, M; Chapman, J; Ghezzi, A; Perini, P; Pozzilli, C; Kalnina, J; Millers, A; Budrys, V; Kizlaitiene, R; Malciene, L; Vaitkus, A; Castro Farfan, G; Gongora Rivera, J; Frequin, S; Gavidia Chucan, J; Perez Villegas, J; Pretell, E; Rodriguez Kadota, L; Fryze, W; Hertmanowska, H; Maciejowski, M; Opala, G; Cerqueira, J; Arefieva, E; Maslova, N; Odinak, M; Pankratov, E; Perfiliev, S; Poverennova, I; Sazonov, D; Shirshova, E; Sivertseva, S; Volkova, L; Vorobyova, O; Knezevic, Z; Raicevic, R; Vojinovic, S; Hancinova, V; Saffova, P; Turcani, P; Vyletelka, J; Coetzee, C; Garcia Merino, A; Hernandez, M; Izquierdo Ayuso, G; Rodriguez Antigüedad, A; Gobbi, C; Belal, S; Frih Ayed, M; Gouider, R; Mrissa, R; Moskovko, S; Sanotskyy, Y; Sokolova, L; Statinova, O; Voloshyna, N; Turner, B; Wilson, M; Applebee, A; Bandari, D; Belkin, M; Birnbaum, G; Borresen, T; Boyd, J; Cascione, M; Cohan, S; Cohen, B; Conway, J; Cree, B; Dihenia, B; Dissin, J; Flitman, S; Ford, C; Giancarlo, T; Gold, S; Green, B; Gwynn, M; Honeycutt, D; Huddlestone, J; Klawiter, E; Kohrman, B; Langer Gould, A; Lava, N; Lindsey, W; Mitchell, G; Naismith, R; Nicolas, J; Pardo, G; Patel, M; Porter, J; Racke, M; Robertson, D; Rossman, H; Schafer, J; Shubin, R; Singer, B; Smith, C; Suski, V; Thrower, B; Wilson, C; Wynn, D; Zabad, R; Estol, C; Scarlatti, A; Alekseenko, Y; Fedulau, A; Kulesh, S; Navumava, H; Willekens, B; Alajbegovic, A; Sinanovic, O; Christo, P; Papais Alvarenga, R; Pereira Damasceno, B; Baldaranov, D; Grigorova, O; Haralanov, L; Milanova, M; Ayotte, C; Blevins, G; Freedman, M; Grand'Maison, F; Jacques, F; Yeung, M; Basic, S; Hajnsek, S; Janko Labinac, D; Kidjemet Piskac, S; Benesova, Y; Hradilek, P; Brassat, D; Edan, G; Hautecoeur, P; Moreau, T; Papeix, C; Tourbah, A; Vukusic, S; Aktas, O; Berthele, A; Bodenschatz, R; Foerch, C; Hohlfeld, R; Landefeld, H; Lang, M; Platten, M; Puzich, R; Schmidt, S; Tubridy, N; Ardito, B; Capra, R; Crociani, P; Danni, M; Grimaldi, L; Gusmaroli, G; Mantegazza, R; Mirabella, M; Uccelli, A; Carbajal Ramirez, A; Lopez Meza, E; Lopez Prieto, J; Oropeza de Alba, J; Reyes Morales, S; San Juan Orta, D; Myhr, K; Binek, M; Czarnecki, M; Klodowska Duda, G; Stelmasiak, Z; Szczudlik, A; Tutaj, A; Belova, A; Dorogov, N; Fedyanin, A; Khasanova, D; Makarov, N; Mishin, G; Sherman, M; Skoromets, A; Trushnikova, T; Donath, V; Dupejova, B; Gurcik, L; Arroyo, R; de Andres, C; Fernandez Fernandez, O; Lainez Andrep, J; Martinez Gines, M; Martinez Rodriguez, J; Martinez Yelamos, S; Oreja Guevara, C; Perez Sempere, A; Ramio, L; Ramo Tello, C; Lycke, J; Olsson, T; Roshanisefat, H; Sundström, P; Svenningsson, A; Akman Demir, G; Petek Balci, B; Boz, C; Efendi, H; Karabudak, R; Siva, A; Terzi, M; Yuceyar, A; Chmyr, G; Goncharova, Y; Kareta, S; Lutskiy, I; Harrower, T; Hawkins, C; Pearson, O; Silber, E; Absher, J; Arnold, T; Bass, A; Bernitsas, E; Braley, T; Calkwood, J; Carnes, K; Coyle, P; Dunn, J; Edwards, K; English, J; Ferencz, G; Fox, E; Frohman, E; Gazda, S; Gitt, J; Goodman, A; Gross, J; Hendin, B; Herrman, C; Hillen, M; Huang, D; Hunter, S; Hutton, G; Jacobs, D; Keller, B; Khan, O; Kister, I; Krupp, L; Lathi, E; Lynch, S; Miller, T; Miravalle, A; Omidvar, O; Perumal, J; Picone, M; Rao, T; Repovic, P; Riskind, P; Rowe, V; Sheremata, W; Steingo, B; Twyman, C; Weisman, D; Wendt, J; Wray, S; Yapundich, R; Zarif, M.; CENTONZE, DIEGO |
| Contributors: |
Hauser, S; Bar Or, A; Comi, G; Giovannoni, G; Hartung, H; Hemmer, B; Lublin, F; Montalban, X; Rammohan, K; Selmaj, K; Traboulsee, A; Wolinsky, J; Arnold, D; Klingelschmitt, G; Masterman, D; Fontoura, P; Belachew, S; Chin, P; Mairon, N; Garren, H; Kappos, L; Reingold, S; Sandberg Wollheim, M; Barkhof, F; Dörmer, T; Evans, S; Mcfarland, H; Steiner, I; Yaldizli, O; D’Souza, M; Andelova, M; Rust, H; Ballario, C; Giannaula, R; Reich, E; Parratt, J; Eggers, C; Buyle, M; Van Pesch, V; Vanopdenbosch, L; Carneiro, D; Friedrich, M; Longo, A; Genov, K; Ivanova, S; Maslarov, D; Lilovski, H; Staikov, I; Cueto, G; Dufek, M; Havrdova, E; Novotna, A; Skoda, O; Talabova, M; Vachova, M; Gross Paju, K; Haldre, S; Elovaara, I; Brochet, B; Castelnovo, G; Clavelou, P; De Seze, J; Debouverie, M; Braune, S; Haas, J; Heidenreich, F; Schwarz, W; Siever, A; Urban, P; Zettl, U; Ziemann, U; Ziemssen, T; Zipp, F; Debreczeni, R; Rozsa, C; Satori, M; Chapman, J; Ghezzi, A; Perini, P; Pozzilli, C; Kalnina, J; Millers, A; Budrys, V; Kizlaitiene, R; Malciene, L; Vaitkus, A; Castro Farfan, G; Gongora Rivera, J; Frequin, S; Gavidia Chucan, J; Perez Villegas, J; Pretell, E; Rodriguez Kadota, L; Fryze, W; Hertmanowska, H; Maciejowski, M; Opala, G; Cerqueira, J; Arefieva, E; Maslova, N |
| Publisher Information: |
Boston, Massachusetts Medical Society; US |
| Publication Year: |
2017 |
| Collection: |
Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| Subject Terms: |
Adult; Antibodies; Monoclonal; Humanized; Antigens; CD20; B-Lymphocyte; Brain; Disease Progression; Female; Human; Immunologic Factor; Infusions; Intravenou; Interferon-beta; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis; Relapsing-Remitting; Recurrence; Settore MED/26 - NEUROLOGIA |
| Description: |
BACKGROUND: B cells influence the pathogenesis of multiple sclerosis. Ocrelizumab is a humanized monoclonal antibody that selectively depletes CD20+ B cells. METHODS: In two identical phase 3 trials, we randomly assigned 821 and 835 patients with relapsing multiple sclerosis to receive intravenous ocrelizumab at a dose of 600 mg every 24 weeks or subcutaneous interferon beta-1a at a dose of 44 μg three times weekly for 96 weeks. The primary end point was the annualized relapse rate. RESULTS: The annualized relapse rate was lower with ocrelizumab than with interferon beta-1a in trial 1 (0.16 vs. 0.29; 46% lower rate with ocrelizumab; P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/28002679; info:eu-repo/semantics/altIdentifier/wos/WOS:000392199100006; volume:376; issue:3; firstpage:221; lastpage:234; numberofpages:14; journal:NEW ENGLAND JOURNAL OF MEDICINE; https://hdl.handle.net/2108/180406 |
| DOI: |
10.1056/NEJMoa1601277 |
| Availability: |
https://hdl.handle.net/2108/180406; https://doi.org/10.1056/NEJMoa1601277 |
| Accession Number: |
edsbas.EC79D439 |
| Database: |
BASE |