| Title: |
Bevacizumab for newly diagnosed ovarian cancers: Best candidates among high-risk disease patients (icon-7) |
| Authors: |
Colomban, O; Tod, M; Peron, J; Perren, TJ; Leary, A; Cook, AD; Sajous, C; Freyer, G; You, B |
| Source: |
JNCI Cancer Spectrum , 4 (3) , Article pkaa026. (2021) |
| Publication Year: |
2021 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
chemotherapy regimen; ca-125 antigen; phase 3 clinical trials; kinetics; neoplasms; ovarian cancer; bevacizumab; elimination rate constant; progression-free survival; datasets |
| Description: |
Bevacizumab is approved as a maintenance treatment in first-line setting in advanced-stage III-IV ovarian cancers, because GOG-0218 and ICON-7 phase III trials demonstrated progression-free survival benefits. However, only the subgroup of patients with high-risk diseases (stage IV, and incompletely resected stage III) derived an overall survival (OS) gain in the ICON-7 trial (4.8 months). The modeled CA-125 elimination rate constant K (KELIM) parameter, based on the longitudinal CA- 125 kinetics during the first 100 days of chemotherapy, is a potential indicator of the tumor primary chemo-sensitivity. In the ICON-7 trial dataset, the OS of patients within the low- and high-risk disease groups was assessed according to treatment arms and KELIM. Among the patients with high-risk diseases, those with favorable standardized KELIM of at least 1.0 (n=214, 46.7%) had no survival benefit from bevacizumab, whereas those with unfavorable KELIM less than 1.0 (n=244, 53.2%) derived the highest OS benefit (absolute difference = 9.1 months, 2-sided log-rank P=.10; Cox hazard ratio = 0.78, 95% confidence interval = 0.58 to 1.04, 2-sided P=.09). |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10123745/1/pkaa026.pdf; https://discovery.ucl.ac.uk/id/eprint/10123745/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10123745/1/pkaa026.pdf; https://discovery.ucl.ac.uk/id/eprint/10123745/ |
| Rights: |
open |
| Accession Number: |
edsbas.ECBDBF8E |
| Database: |
BASE |