| Title: |
Association of Alterations in ParC and GyrA Proteins with Resistance of Clinical Isolates of Enterococcus faecium to Nine Different Fluoroquinolones |
| Authors: |
Brisse, Sylvain; Fluit, Ad C.; Wagner, Ulrich; Heisig, Peter; Milatovic, Dana; Verhoef, Jan; Scheuring, Sybille; Köhrer, Karl; Schmitz, Franz-Josef |
| Source: |
Antimicrobial Agents and Chemotherapy ; volume 43, issue 10, page 2513-2516 ; ISSN 0066-4804 1098-6596 |
| Publisher Information: |
American Society for Microbiology |
| Publication Year: |
1999 |
| Description: |
The parC and gyrA genes of 73 ciprofloxacin-resistant and 6 ciprofloxacin-susceptible Enterococcus faecium clinical isolates were partly sequenced. Alterations in ParC and GyrA, possibly in combination with other resistance mechanisms, severely restricted the in vitro activities of the nine quinolones tested. For all isolates, clinafloxacin and sitafloxacin showed the best activities. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1128/aac.43.10.2513 |
| DOI: |
10.1128/AAC.43.10.2513 |
| Availability: |
https://doi.org/10.1128/aac.43.10.2513; https://journals.asm.org/doi/pdf/10.1128/AAC.43.10.2513 |
| Rights: |
https://journals.asm.org/non-commercial-tdm-license |
| Accession Number: |
edsbas.ECE1A78C |
| Database: |
BASE |