| Title: |
Added Value of [18F]PSMA-1007 PET/CT and PET/MRI in Patients With Biochemically Recurrent Prostate Cancer:Impact on Detection Rates and Clinical Management |
| Authors: |
Abrahamsen, Bendik S.; Tandstad, Torgrim; Aksnessæther, Bjørg Y.; Bogsrud, Trond V.; Castillejo, Miguel; Hernes, Eivor; Johansen, Håkon; Keil, Thomas M.I.; Knudtsen, Ingerid S.; Langørgen, Sverre; Selnæs, Kirsten M.; Bathen, Tone F.; Elschot, Mattijs |
| Source: |
Abrahamsen, B S, Tandstad, T, Aksnessæther, B Y, Bogsrud, T V, Castillejo, M, Hernes, E, Johansen, H, Keil, T M I, Knudtsen, I S, Langørgen, S, Selnæs, K M, Bathen, T F & Elschot, M 2025, 'Added Value of [18F]PSMA-1007 PET/CT and PET/MRI in Patients With Biochemically Recurrent Prostate Cancer : Impact on Detection Rates and Clinical Management', Journal of Magnetic Resonance Imaging, vol. 61, no. 1, pp. 466-477. https://doi.org/10.1002/jmri.29386 |
| Publication Year: |
2025 |
| Collection: |
Aarhus University: Research |
| Subject Terms: |
biochemical recurrence; PET/CT; PET/MRI; prostate cancer; PSMA PET |
| Description: |
Background: Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) can change management in a large fraction of patients with biochemically recurrent prostate cancer (BCR). Purpose: To investigate the added value of PET to MRI and CT for this patient group, and to explore whether the choice of the PET paired modality (PET/MRI vs. PET/CT) impacts detection rates and clinical management. Study Type: Retrospective. Subjects: 41 patients with BCR (median age [range]: 68 [55–78]). Field Strength/Sequence: 3T, including T1-weighted gradient echo (GRE), T2-weighted turbo spin echo (TSE) and dynamic contrast-enhanced GRE sequences, diffusion-weighted echo-planar imaging, and a T1-weighted TSE spine sequence. In addition to MRI, [ 18 F]PSMA-1007 PET and low-dose CT were acquired on the same day. Assessment: Images were reported using a five-point Likert scale by two teams each consisting of a radiologist and a nuclear medicine physician. The radiologist performed a reading using CT and MRI data and a joint reading between radiologist and nuclear medicine physician was performed using MRI, CT, and PET from either PET/MRI or PET/CT. Findings were presented to an oncologist to create intended treatment plans. Intrareader and interreader agreement analysis was performed. Statistical Tests: McNemar test, Cohen's κ, and intraclass correlation coefficients. A P-value |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
1053-1807; 1522-2586 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/38679841; info:eu-repo/semantics/altIdentifier/pissn/1053-1807; info:eu-repo/semantics/altIdentifier/eissn/1522-2586 |
| DOI: |
10.1002/jmri.29386 |
| Availability: |
https://pure.au.dk/portal/en/publications/95a0b61f-4a77-4a9c-a6c6-b6451f69d012; https://doi.org/10.1002/jmri.29386; https://www.scopus.com/pages/publications/85191767632 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.ECE842B0 |
| Database: |
BASE |