| Title: |
Contacting the gut: Mitochondria-associated Endoplasmic Reticulum Membranes in the Enteric Nervous System |
| Authors: |
Greig, Jenny; Delfino, Giada; Derkinderen, Pascal; Paillusson, Sébastien |
| Contributors: |
Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI); Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE); Nantes Université - pôle Santé; Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé; Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ); Team 2 : Cell and gene engineering in tolerance, fertility and regenerative medicine (Team 2 - U1064 Inserm - CR2TI); Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE); The Enteric Nervous System in gut and brain disorders U1235 (TENS); Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes) |
| Source: |
ISSN: 2515-2564. |
| Publisher Information: |
CCSD; Sage |
| Publication Year: |
2024 |
| Collection: |
Université de Nantes: HAL-UNIV-NANTES |
| Subject Terms: |
mitochondria-associated ER membranes; enteric nervous system; ageing; Parkinson's disease; Alzheimer's disease; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Changes in the connections between the endoplasmic reticulum (ER) and mitochondria, as well as alterations in mitochondria-associated ER membrane (MAM) signalling, have been documented in various neurodegenerative diseases affecting the brain. Despite the growing recognition of the significance of the gut-brain axis in neurodegenerative conditions, there has been no prior investigation into the biology of MAM within the enteric nervous system (ENS). Our recent research reveals, for the first time, the existence of connections between the ER and mitochondria within enteric neurons. Additionally, we observed alterations in the dynamics of these connections in the enteric neurons from a mouse model exhibiting age-related neurodegeneration. These findings provide the first detailed characterization of MAM in the ENS under physiological conditions and in a mouse model of age-associated neurodegeneration and shed new light on the potential role of enteric MAM in the context of neurodegenerative disorders. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/38585502; PUBMED: 38585502; PUBMEDCENTRAL: PMC10998439 |
| DOI: |
10.1177/25152564241244941 |
| Availability: |
https://inserm.hal.science/inserm-04587199; https://inserm.hal.science/inserm-04587199v1/document; https://inserm.hal.science/inserm-04587199v1/file/greig-et-al-2024-contacting-the-gut-mitochondria-associated-endoplasmic-reticulum-membranes-in-the-enteric-nervous.pdf; https://doi.org/10.1177/25152564241244941 |
| Rights: |
http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.ECED832A |
| Database: |
BASE |