| Title: |
Memory lapses in graft‐versus‐host disease |
| Authors: |
Flutter, Barry; Veliça, Pedro; Chakraverty, Ronjon |
| Source: |
European Journal of Immunology ; volume 41, issue 9, page 2530-2534 ; ISSN 0014-2980 1521-4141 |
| Publisher Information: |
Wiley |
| Publication Year: |
2011 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
“Faster, better, more” is the conventional benchmark used to define responses of memory T cells when compared with their naïve counterparts. In this issue of the European Journal of Immunology , Mark and Warren Shlomchik and colleagues [ Eur. J. Immunol . 2011. 41 : 2782–2792] make the intriguing observation that murine memory CD4 + T‐cell populations enriched for alloreactive precursors are fully capable of rejecting allogeneic skin grafts but yet are incapable of inducing significant graft‐versus‐host disease. These observations add to the emerging concept that memory CD4 + T‐cell development is more nuanced and complex than predicted by conventional models. In particular, the data suggest that it may be just as important to consider what naïve or effector cells have “lost” in their transition to memory. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1002/eji.201141946 |
| Availability: |
http://dx.doi.org/10.1002/eji.201141946; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Feji.201141946; https://onlinelibrary.wiley.com/doi/pdf/10.1002/eji.201141946 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.ED7030C8 |
| Database: |
BASE |