| Title: |
PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment ; Acta Neuropathol |
| Authors: |
KLEINEIDAM, L.; CHOURAKI, V.; PROCHNICKI, T.; VAN DER LEE, S. J.; MADRID-MARQUEZ, L.; WAGNER-THELEN, H.; KARACA, I.; WEINHOLD, L.; WOLFSGRUBER, S.; BOLAND, A.; MARTINO ADAMI, P. V.; LEWCZUK, P.; POPP, J.; BROSSERON, F.; JANSEN, I. E.; HULSMAN, M.; KORNHUBER, J.; PETERS, O.; BERR, C.; HEUN, R.; FROLICH, L.; TZOURIO, Christophe; DARTIGUES, Jean-Francois; HULL, M.; ESPINOSA, A.; HERNANDEZ, I.; DE ROJAS, I.; ORELLANA, A.; VALERO, S.; STRINGA, N.; VAN SCHOOR, N. M.; HUISMAN, M.; SCHELTENS, P.; ALZHEIMER'S DISEASE NEUROIMAGING, Initiative; RUTHER, E.; DELEUZE, J. F.; WILTFANG, J.; TARRAGA, L.; SCHMID, M.; SCHERER, M.; RIEDEL-HELLER, S.; HENEKA, M. T.; AMOUYEL, Philippe; JESSEN, F.; BOADA, M.; MAIER, W.; SCHNEIDER, A.; GONZALEZ-PEREZ, A.; VAN DER FLIER, W. M.; WAGNER, M.; LAMBERT, J. C.; HOLSTEGE, H.; SAEZ, M. E.; LATZ, E.; RUIZ, A.; RAMIREZ, A. |
| Publication Year: |
2020 |
| Subject Terms: |
SEPIA; HEALTHY; Sciences du Vivant [q-bio]/Santé publique et épidémiologie |
| Description: |
pinnings, we identified a network of co-expressed proteins connecting PLCG2 to APOE and TREM2 using unsupervised co-regulatory network analysis. The network was highly enriched for the complement cascade and genes differentially expressed in disease-associated microglia. Our data show that p.P522R in PLCG2 reduces AD disease progression by mitigating tau pathology in the presence of amyloid pathology and, as a consequence, maintains cognitive function. Targeting the enzyme PLCG2 might provide a new therapeutic approach for treating AD. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1007/s00401-020-02138-6 |
| Availability: |
https://oskar-bordeaux.fr/handle/20.500.12278/26338; https://hdl.handle.net/20.500.12278/26338; https://doi.org/10.1007/s00401-020-02138-6 |
| Rights: |
Attribution 3.0 United States ; open ; http://creativecommons.org/licenses/by/3.0/us/ |
| Accession Number: |
edsbas.ED839771 |
| Database: |
BASE |