| Title: |
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids |
| Authors: |
Bentley, AR; Sung, YJ; Brown, MR; Winkler, TW; Kraja, AT; Ntalla, I; Schwander, K; Chasman, DI; Lim, E; Deng, X; Guo, X; Liu, J; Lu, Y; Cheng, C-Y; Sim, X; Vojinovic, D; Huffman, JE; Musani, SK; Li, C; Feitosa, MF; Richard, MA; Noordam, R; Baker, J; Chen, G; Aschard, H; Bartz, TM; Ding, J; Dorajoo, R; Manning, AK; Rankinen, T; Smith, AV; Tajuddin, SM; Zhao, W; Graff, M; Alver, M; Boissel, M; Chai, JF; Chen, X; Divers, J; Evangelou, E; Gao, C; Goel, A; Hagemeijer, Y; Harris, SE; Hartwig, FP; He, M; Horimoto, ARVR; Hsu, F-C; Hung, Y-J; Jackson, AU; Kasturiratne, A; Komulainen, P; Kuehnel, B; Leander, K; Lin, K-H; Luan, J; Lyytikainen, L-P; Matoba, N; Nolte, IM; Pietzner, M; Prins, B; Riaz, M; Robino, A; Said, MA; Schupf, N; Scott, RA; Sofer, T; Stancakova, A; Takeuchi, F; Tayo, BO; van der Most, PJ; Varga, TV; Wang, T-D; Wang, Y; Ware, EB; Wen, W; Xiang, Y-B; Yanek, LR; Zhang, W; Zhao, JH; Adeyemo, A; Afaq, S; Amin, N; Amini, M; Arking, DE; Arzumanyan, Z; Aung, T; Ballantyne, C; Barr, RG; Bielak, LF; Boerwinkle, E; Bottinger, EP; Broeckel, U; Brown, M; Cade, BE; Campbell, A; Canouil, M; Charumathi, S; Chen, Y-DI; Christensen, K; Concas, MP; Connell, JM; de las Fuentes, L; de Silva, HJ; de Vries, PS; Doumatey, A; Duan, Q; Eaton, CB; Eppinga, RN; Faul, JD; Floyd, JS; Forouhi, NG; Forrester, T; Friedlander, Y; Gandin, I; Gao, H; Ghanbari, M; Gharib, SA; Gigante, B; Giulianini, F; Grabe, HJ; Gu, CC; Harris, TB; Heikkinen, S; Heng, C-K; Hirata, M; Hixson, JE; Ikram, MA; Jia, Y; Joehanes, R; Johnson, C; Jonas, JB; Justice, AE; Katsuya, T; Khor, CC; Kilpelainen, TO; Koh, W-P; Kolcic, I; Kooperberg, C; Krieger, JE; Kritchevsky, SB; Kubo, M; Kuusisto, J; Lakka, TA; Langefeld, CD; Langenberg, C; Launer, LJ; Lehne, B; Lewis, CE; Li, Y; Liang, J; Lin, S; Liu, C-T; Liu, K; Loh, M; Lohman, KK; Louie, T; Luzzi, A; Magi, R; Mahajan, A; Manichaikul, AW; McKenzie, CA; Meitinger, T; Metspalu, A; Milaneschi, Y; Milani, L; Mohlke, KL; Momozawa, Y; Morris, AP; Murray, AD; Nalls, MA; Nauck, M; Nelson, CP; North, KE; O'Connell, JR; Palmer, ND; Papanicolau, GJ; Pedersen, NL; Peters, A; Peyser, PA; Polasek, O; Poulter, N; Raitakari, OT; Reiner, AP; Renstrom, F; Rice, TK; Rich, SS; Robinson, JG; Rose, LM; Rosendaal, FR; Rudan, I; Schmidt, CO; Schreiner, PJ; Scott, WR; Sever, P; Shi, Y; Sidney, S; Sims, M; Smith, JA; Snieder, H; Starr, JM; Strauch, K; Stringham, HM; Tan, NYQ; Tang, H; Taylor, KD; Teo, YY; Tham, YC; Tiemeier, H; Turner, ST; Uitterlinden, AG; van Heemst, D; Waldenberger, M; Wang, H; Wang, L; Wei, WB; Williams, CA; Sr, WG; Wojczynski, MK; Yao, J; Young, K; Yu, C; Yuan, J-M; Zhou, J; Zonderman, AB; Becker, DM; Boehnke, M; Bowden, DW; Chambers, JC; Cooper, RS; de Faire, U; Deary, IJ; Elliott, P; Esko, T; Farrall, M; Franks, PW; Freedman, BI; Froguel, P; Gasparini, P; Gieger, C; Horta, BL; Juang, J-MJ; Kamatani, Y; Kammerer, CM; Kato, N; Kooner, JS; Laakso, M; Laurie, CC; Lee, I-T; Lehtimaki, T; Magnusson, PKE; Oldehinkel, AJ; Penninx, BWJH; Pereira, AC; Rauramaa, R; Redline, S; Samani, NJ; Scott, J; Shu, X-O; van der Harst, P; Wagenknecht, LE; Wang, J-S; Wang, YX; Wareham, NJ; Watkins, H; Weir, DR; Wickremasinghe, AR; Wu, T; Zeggini, E; Zheng, W; Bouchard, C; Evans, MK; Gudnason, V; Kardia, SLR; Liu, Y; Psaty, BM; Ridker, PM; van Dam, RM; Mook-Kanamori, DO; Fornage, M; Province, MA; Kelly, TN; Fox, ER; Hayward, C; van Duijn, CM; Tai, ES; Wong, TY; Loos, RJF; Franceschini, N; Rotter, JI; Zhu, X; Bierut, LJ; Gauderman, WJ; Rice, K; Munroe, PB; Morrison, AC; Rao, DC; Rotimi, CN; Cupples, LA; Consortium, C-K; Consortium, E-I; Grp, USS; Cohort, L |
| Publisher Information: |
Nature Research (part of Springer Nature) |
| Publication Year: |
2019 |
| Collection: |
Queen Mary University of London: Queen Mary Research Online (QMRO) |
| Description: |
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings. |
| Document Type: |
article in journal/newspaper |
| File Description: |
636 - 648 |
| Language: |
English |
| Relation: |
NATURE GENETICS; https://qmro.qmul.ac.uk/xmlui/handle/123456789/58835 |
| DOI: |
10.1038/s41588-019-0378-y |
| Availability: |
https://qmro.qmul.ac.uk/xmlui/handle/123456789/58835; https://doi.org/10.1038/s41588-019-0378-y |
| Rights: |
Copyright © 2019, Springer Nature |
| Accession Number: |
edsbas.EDDBD8C4 |
| Database: |
BASE |