| Title: |
Cancer burden and risk factors among women with HIV: a multi-regional study from the D:A:D and RESPOND cohort collaborations |
| Authors: |
Han, Win Min; Neesgaard, Bastian; Knappik, Michael; Cavassini, Matthias; Abela, Irene A.; Timiryasova, Alisa; Greenberg, Lauren; Martin, Charlotte; Mussini, Cristina; Wit, Ferdinand; Sabin, Caroline; Castagna, Antonella; Abutidze, Akaki; El-Sadr, Wafaa; Bonnet, Fabrice; Sarcletti, Mario; Carlander, Christina; Hachfeld, Anna; Weis, Nina; Vannappagari, Vani; Rogatto, Felipe P.; Young, Lital A.; Hosein, Sean R.; Ryom, Lene; Petoumenos, Kathy; El-Sadr, W.; Calvo, G.; Bonnet, F.; Dabis, F.; Kirk, O.; Mocroft, A.; Law, M.; d'Arminio Monforte, A.; Morfeldt, L.; Pradier, C.; Reiss, P.; Weber, R.; De Wit, S.; Lind-Thomsen, A.; Salbøl Brandt, R.; Hillebreght, M.; Zaheri, S.; Wit, F.; Scherrer, A.; Schöni-Affolter, F.; Rickenbach, M.; Tavelli, A.; Fanti, I.; Leleux, O.; Mourali, J.; Le Marec, F.; Boerg, E.; Thulin, E.; Sundström, A.; Bartsch, G.; Thompsen, G.; Necsoi, C.; Delforge, M.; Fontas, E.; Caissotti, C.; Dollet, K.; Mateu, S.; Torres, F.; Petoumenos, K.; Blance, A.; Huang, R.; Puhr, R.; Grønborg Laut, K.; Kristensen, D.; Sabin, C.; Phillips, A.; Kamara, D.; Smith, C.; Hatleberg, C.; Ryom, L.; Brandt, R.; Raben, D.; Matthews, C.; Bojesen, A.; Grevsen, A.; Lundgren, J.; Powderly, B.; Shortman, N.; Moecklinghoff, C.; Reilly, G.; Franquet, X.; Smit, C.; Ross, M.; Fux, C.; Morlat, P.; Friis-Møller, N.; Kowalska, J.; Bohlius, J.; Bower, M.; Fätkenheuer, G.; Grulich, A.; Sjøl, A.; Meidahl, P.; Iversen, J.; van der Valk, M.; Hillebregt, M.; Min Han, W.; Zangerle, R.; Appoyer, H.; Vera, J.; Clarke, A.; Broster, B.; Barbour, L.; Carney, D.; Greenland, L.; Coughlan, R.; Begovac, J.; Stephan, C.; Bucht, M.; Chkhartishvili, N.; Chokoshvili, O.; Rodano, A.; Mussini, C.; Borghi, V.; Menozzi, M.; Cervo, A.; Casabona, J.; Miro, J.; Burns, F.; Lampe, F.; Chaloner, C.; Castagna, A.; Lazzarin, A.; Lolatto, R.; Sönnerborg, A.; Carlander, C.; Nowal, P.; Vesterbacka, J.; Carrick, D.; Stigsäter, K.; Mattson, L.; Günthard, H.; Kusejko, K.; Wasmuth, J.; Rockstroh, J.; Vehreschild, J.; Scherer, M.; Sauer, G.; Schulze, N.; Campo, R.; Garges, H.; Bognar, F.; Rooney, J.; Vannappagari, V.; Wandeler, G.; Young, L.; Dedes, N.; Dunbar, M.; Peters, L.; Volny-Anne, A.; Greenberg, L.; Jaschinski, N.; Timiryasova, A.; Bansi-Matharu, L.; Tusch, E.; Bannister, W.; Roen, A.; Byonanebye, D.; Fursa, O.; Pelchen-Matthews, A.; Reekie, J.; Svedhem-Johansson, V.; Grabmeier-Pfistershammer, K.; Hoy, J.; Bloch, M.; Braun, D.; Calmy, A.; Schüttfort, G.; Youle, M.; Zona, S.; Antinori, A.; Bolokadze, N.; Llibre, J.; Schwarze-Zander, C.; Hutchinson, J.; Duvivier, C.; Dragovic, G.; Radoi, R.; Oprea, C.; Vasylyev, M.; Matulionyte, R.; Mulabdic, V.; Marchetti, G.; Kuzovatova, E.; Coppola, N.; Aho, I.; Martini, S.; Bucher, H.; Harxhi, A.; Wæhre, T.; Pharris, A.; Vassilenko, A.; Bogner, J.; Maagaard, A.; Jablonowska, E.; Elbirt, D.; Marrone, G.; Leen, C.; Wyen, C.; Dahlerup Rasmussen, L.; Kundro, M.; Dixon Williams, E.; Gallant, J.; Cohen, C.; Marongiu, A.; Ekström, A.; Elvstam, O.; Gruber, J.; Hosein, J.; Weibull Wärnberg, A.; Xu, X.; Mendão, L.; Valdenmaier, O.; Larsen, J. F.; Gardizi, M.; Elsing, T. W.; Ramesh Kumar, L.; Pepa, B.; Abutidze, A. |
| Contributors: |
Han, Win Min; Neesgaard, Bastian; Knappik, Michael; Cavassini, Matthia; Abela, Irene A.; Timiryasova, Alisa; Greenberg, Lauren; Martin, Charlotte; Mussini, Cristina; Wit, Ferdinand; Sabin, Caroline; Castagna, Antonella; Abutidze, Akaki; El-Sadr, Wafaa; Bonnet, Fabrice; Sarcletti, Mario; Carlander, Christina; Hachfeld, Anna; Weis, Nina; Vannappagari, Vani; Rogatto, Felipe P.; Young, Lital A.; Hosein, Sean R.; Ryom, Lene; Petoumenos, Kathy; El-Sadr, W.; Calvo, G.; Bonnet, F.; Dabis, F.; Kirk, O.; Mocroft, A.; Law, M.; D'Arminio Monforte, A.; Morfeldt, L.; Pradier, C.; Reiss, P.; Weber, R.; De Wit, S.; Lind-Thomsen, A.; Salbøl Brandt, R.; Hillebreght, M.; Zaheri, S.; Wit, F.; Scherrer, A.; Schöni-Affolter, F.; Rickenbach, M.; Tavelli, A.; Fanti, I.; Leleux, O.; Mourali, J.; Le Marec, F.; Boerg, E.; Thulin, E.; Sundström, A.; Bartsch, G.; Thompsen, G.; Necsoi, C.; Delforge, M.; Fontas, E.; Caissotti, C.; Dollet, K.; Mateu, S.; Torres, F.; Petoumenos, K.; Blance, A.; Huang, R.; Puhr, R.; Grønborg Laut, K.; Kristensen, D.; Sabin, C.; Phillips, A.; Kamara, D.; Smith, C.; Hatleberg, C.; Ryom, L.; Brandt, R.; Raben, D.; Matthews, C.; Bojesen, A.; Grevsen, A.; Lundgren, J.; Powderly, B.; Shortman, N.; Moecklinghoff, C.; Reilly, G.; Franquet, X.; Smit, C.; Ross, M.; Fux, C.; Morlat, P. |
| Publication Year: |
2026 |
| Collection: |
Archivio della ricerca dell'Università di Modena e Reggio Emilia (Unimore: IRIS) |
| Subject Terms: |
Cancer incidence; HPV; Modifiable risk factor; Observational cohort study; Women with HIV |
| Description: |
Background Data on cancer incidence and associated risk factors among women with HIV are limited. We investigated cancer burden among women with HIV. Methods We included all women >= 18 years from the two large multicentre observational cohort collaborations (D:A:D and RESPOND). The primary outcomes were incidence of all cancers, HPV-related and common individual cancers including breast cancer, lung cancer, and non-Hodgkin lymphoma (NHL) from 2006 to 2021. Baseline was defined as the latest date of entry into local cohort enrolment and 1st January 2006 for D:A:D and 1st January 2012 for RESPOND. Participants were followed from baseline until the date of first cancer, final follow-up or administrative censoring-whichever occurred first. We assessed risk factors using multivariable Poisson regression by applying robust standard errors and determined a population attributable fraction (PAF) for key risk factors for cancers. Findings Among 17,512 women included, median age at baseline was 39.5 years (interquartile range, IQR 32.5-46.0). Over 141,404 person-years (PYS) and a median 9.2 (5.5-10.1) years of follow-up, 832 women were diagnosed with any cancer; incidence rate 5.9 (95% CI 5.5-6.4)/1000 PYS, 163 HPV-related cancers (1.1 [1.0-1.3]/1000 PYS), 150 breast cancers (1.1 [0.9-1.2]/1000 PYS), 94 lung cancers (0.7 [0.5-0.8]/1000 PYS) and 72 NHL (0.5 [0.4-0.6]/1000 PYS). Older age (>= 45 vs. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/41567716; info:eu-repo/semantics/altIdentifier/wos/WOS:001666213100001; volume:91; firstpage:1; lastpage:16; journal:ECLINICALMEDICINE; https://hdl.handle.net/11380/1396090 |
| DOI: |
10.1016/j.eclinm.2025.103739 |
| Availability: |
https://hdl.handle.net/11380/1396090; https://doi.org/10.1016/j.eclinm.2025.103739 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:[IR] creative-commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.EE121752 |
| Database: |
BASE |