| Title: |
A novel model to quantify blood transit time in cerebral arteries using ASL-based 4D magnetic resonance angiography with example clinical application in moyamoya disease |
| Authors: |
Bhogal, Alex A.; Uniken Venema, Simone M.; Deckers, Pieter T.; van de Ven,Kim; Versluis,Maarten; Braun, Kees P.; van der Zwan, Albert; Siero, Jeroen C.W.; Neurovascular Imaging Group; Cancer; Circulatory Health; Arts-assistenten Radiologie; Neurologen; Brain; Neurochirurgen; Precision Imaging Group |
| Publication Year: |
2025 |
| Subject Terms: |
4D-MRA; Angiography; arterial transit time; cerebrovascular reactivity; moyamoya; multi-PLD pCASL; steno occlusive disease; Neurology; Clinical Neurology; Cardiology and Cardiovascular Medicine; Journal Article |
| Description: |
Angiography is critical for visualizing cerebral blood flow in intracranial steno-occlusive diseases. Current 4D magnetic resonance angiography (MRA) techniques primarily focus on macrovascular structures, yet few have quantified hemodynamic timing. This study introduces a novel model to estimate macrovascular arterial transit time (mATT) derived from arterial spin labeling (ASL)-based 4D-MRA. We provide examples of our method that visualize mATT differences throughout the brain of patients with intracranial steno-occlusive disease (moyamoya), as well as changes in mATT resulting from the cerebrovascular reactivity response to an acetazolamide (ACZ) injection. Furthermore, we present a method that projects sparse arterial signals into a 3D native brain-region atlas space and correlates regional mATT with other hemodynamic parameters of interest, such as tissue transit time and cerebrovascular reactivity. This approach offers a non-invasive, quantitative assessment of macrovascular dynamics, with potential to enhance understanding of large-vessel and tissue-level hemodynamics and augment monitoring of treatment outcomes in steno-occlusive disease patients. Furthermore, it sets the stage for more in-depth investigations of the macrovascular contribution to brain hemodynamics. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
0271-678X |
| Relation: |
https://dspace.library.uu.nl/handle/1874/465515 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/465515 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.EE6D6ED5 |
| Database: |
BASE |