| Title: |
Immunogenicity of Abdala COVID-19 vaccine in Vietnamese people after primary and booster vaccinations: a prospective observational study in Vietnam |
| Authors: |
Thanh, TT; Tu, NTK; Nguyet, LA; Thuy, CT; Thuan, NLT; Ny, NTH; Nhu, LNT; Thanh, LK; Hong, NTT; Anh, NT; Truong, NT; Chau, NVV; Yen, LM; Van E, P; Thuong, NP; Van Truc, N; Trung, PH; Yap, WC; Pandey, R; Yee, S; Weng, R; Mongkolsapaya, J; Dejnirattisai, W; Hamers, RL; Chantratita, N; Screaton, G; Dunachie, SJ; Jones, EY; Stuart, DI; Dung, NT; Thwaites, G; Wang, L-F; Tan, CW; Tan, LV |
| Contributors: |
Consortia, SECOVARIANTS and ASSeSS |
| Publisher Information: |
Elsevier |
| Publication Year: |
2025 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
Objectives We studied the immunogenicity after primary and booster vaccinations of the Abdala COVID-19 vaccine, a receptor-binding domain protein subunit vaccine, in Vietnamese people by determining the level of neutralization and cross-neutralization activities against the ancestral SARS-CoV-2 and its variants and SARS-CoV-1. Methods We performed a prospective observational study, enrolling adults aged 19-59 years in Dong Thap province, southern Vietnam, and collected blood samples from baseline until 4 weeks after the booster dose. We measured anti-nucleocapsid, anti-spike, and neutralizing antibodies against SARS-CoV-2 and assessed the cross-neutralization against 14 SARS-CoV-2 variants and SARS-CoV-1. Complementary antibody data came from Vietnamese health care workers fully vaccinated with ChAdOx1-S. Results After primary vaccination, anti-spike antibody and neutralizing antibodies were detectable in 98.4% and 87% of 251 study participants, respectively, with neutralizing antibody titers similar to that induced by ChAdOx1-S vaccine. Antibody responses after a homologous (Abdala COVID-19) or heterologous (messenger RNA BNT162b2) booster could neutralize 14 SARS-CoV-2 variants (including Omicron) and SARS-CoV-1. Conclusions Abdala COVID-19 vaccine is immunogenic in Vietnamese people. Enhanced antibody response after a booster dose could cross-neutralize 14 SARS-CoV-2 variants and SARS-CoV-1. Our results have added to the growing body of knowledge about the contribution of protein subunit vaccine platforms to pandemic control. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://doi.org/10.1016/j.ijid.2024.107173 |
| DOI: |
10.1016/j.ijid.2024.107173 |
| Availability: |
https://doi.org/10.1016/j.ijid.2024.107173; https://ora.ox.ac.uk/objects/uuid:0d404513-dffd-444b-9f21-c31846771ec7 |
| Rights: |
info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| Accession Number: |
edsbas.EED412A7 |
| Database: |
BASE |