| Title: |
Whole-brain volumetric analysis in adult moyamoya patients reveals significant atrophy compared to healthy controls |
| Authors: |
Haas, Patrick; Debolski, Alexander; Bender, Benjamin; Zerweck, Leonie; Ernemann, Ulrike; Tatagiba, Marcos; Hauser, Till-Karsten; Khan, Nadia; Roder, Constantin |
| Source: |
Brain Communications ; ISSN 2632-1297 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2025 |
| Description: |
Moyamoya disease (MMD) may lead to perfusion deficits, stroke and brain atrophy in the long term. Our aim was to analyze whole-brain volumetry (WBV) of a large cohort of MMD patients compared to healthy controls. 3D T1w MRI sequences of adult MMD patients treated at our center between 2016-2022 without prior revascularization were analyzed for WBV (AssemblyNet) and compared age-controlled to healthy controls (HC). A total of 133 different regions of interest (ROI) were examined retrospectively for each patient separately by localization, structure and tissue type. All segmentations were subjected to automated and manual quality control (QC). After QC, 149 hemispheres from 80 MMD patients were compared to 258 hemispheres from 129 HC. A significant brain volume loss was observed in MMD patients with increasing age, with the greatest reduction seen in bilaterally affected patients with Suzuki grade >3. As direct signs of brain atrophy, significant differences were seen across all ROIs, emphasized in cortical gray matter (GM) with a reduction of 4.4% (95%CI 2.7%–6.1%; p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/braincomms/fcaf100 |
| DOI: |
10.1093/braincomms/fcaf100/62244339/fcaf100.pdf |
| Availability: |
https://doi.org/10.1093/braincomms/fcaf100; https://academic.oup.com/braincomms/advance-article-pdf/doi/10.1093/braincomms/fcaf100/62244339/fcaf100.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.EEEF5A76 |
| Database: |
BASE |