| Title: |
99Increasing prevalence of primary biliary cholangitis in Victoria, Australia |
| Authors: |
French, Janine; van der Mei, Ingrid; Simpson-Yap, Steve; Ng, Justin; Angus, Peter; Lubel, John; Nicholl, Amanda; Sood, Siddharth; Roberts, Stuart; Kemp, William; Arachchi, Niranjan; Dev, Anouk; Thompson, Alexander; Gow, Paul |
| Source: |
International Journal of Epidemiology ; volume 50, issue Supplement_1 ; ISSN 0300-5771 1464-3685 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2021 |
| Description: |
Background The prevalence of primary biliary cholangitis (PBC) reported in different countries varies significantly and in some parts of the world appears to be increasing. The aim of this study was to determine the 2013 prevalence of PBC in Victoria, Australia, and to determine the time trend by comparing it with previous studies undertaken in 1991 and 2002. Methods Four case-finding methods were used to identify cases of PBC in Victoria: (1) physicians’ survey; (2) tertiary hospital search; (3) liver transplant database search; and (4) private pathology antimitochondrial antibody search. Results The prevalence of PBC in Victoria, Australia, is 189.0 per million using all four methods. The average annual increase in prevalence from 1991 to 2013 was 7.7 per million per year. Using the same case-finding methods as the 1991 Victorian prevalence study (methods 1 and 2), the prevalence of PBC increased from 19.1 per million in 1991 to 49.4 per million in 2002 (P < 0.001) and to 80.7 per million in 2013 (P < 0.001). Conclusions The current prevalence of PBC in Victoria is significantly higher than previously reported. The use of private pathology-based case-finding methods is important in identifying the maximum number of PBC cases. Key messages PBC prevalence in Victoria increased significantly since previous surveys, to 189 per million persons. Including pathology-based case ascertainment yields improved identification of cases. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/ije/dyab168.608 |
| Availability: |
https://doi.org/10.1093/ije/dyab168.608; http://academic.oup.com/ije/article-pdf/50/Supplement_1/dyab168.608/40212554/dyab168.608.pdf |
| Rights: |
https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
| Accession Number: |
edsbas.EEEFB3F |
| Database: |
BASE |