| Title: |
De Novo Pulmonary Vein Isolation by Means of Pulsed Field Versus Conventional Thermal Ablation of Paroxysmal Atrial Fibrillation in Women: Safety, Efficiency, and Efficacy |
| Authors: |
Ribatti, Valentina; Dello Russo, Antonio; Riva, Stefania; Malacrida, Maurizio; Bianchi, Stefano; Solimene, Francesco; Iacopino, Saverio; De Simone, Antonio; Rossillo, Antonio; Pelargonio, Gemma; Zucchelli, Giulio; Maggio, Ruggero; Russo, Maurizio; Pecora, Domenico; Bertini, Matteo; Bandino, Stefano; Volpicelli, Mario; Compagnucci, Paolo; De Sanctis, Valerio; Anselmino, Matteo; Rordorf, Roberto; Zingarini, Gianluca; Rovaris, Giovanni; Agus, Elena; Themistoclakis, Sakis; Mitacchione, Gianfranco; Mea, Roberta; Valeri, Yari; Tondo, Claudio; Casella, Michela |
| Contributors: |
V. Ribatti; A. Dello Russo; S. Riva; M. Malacrida; S. Bianchi; F. Solimene; S. Iacopino; A. De Simone; A. Rossillo; G. Pelargonio; G. Zucchelli; R. Maggio; M. Russo; D. Pecora; M. Bertini; S. Bandino; M. Volpicelli; P. Compagnucci; V. De Sancti; M. Anselmino; R. Rordorf; G. Zingarini; G. Rovari; E. Agu; S. Themistoclaki; G. Mitacchione; R. Mea; Y. Valeri; C. Tondo; M. Casella |
| Publisher Information: |
Wiley Blackwell Publishing |
| Publication Year: |
2026 |
| Collection: |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: |
atrial fibrillation; catheter ablation; electroporation; female sex; pulsed‐field ablation; thermal ablation; women; Settore MEDS-07/B - Malattie dell'apparato cardiovascolare |
| Description: |
Background: Women are frequently underrepresented in studies investigating atrial fibrillation (AF) ablation. We evaluated the acute efficacy, safety, and mid-term outcomes of de novo paroxysmal AF ablation in female patients using a pentaspline pulsed-field ablation (PFA) versus thermal-based technologies. Methods: In a cohort of consecutive female patients with paroxysmal AF undergoing de novo pulmonary vein isolation, enrolled in the ATHENA-CHARISMA (Advanced Technologies For Successful Ablation of AF in Clinical Practice - Catheter Ablation of Arrhythmias With High-DensityMapping System in the Real WorldPractice) registries, thermal ablation systems (radiofrequency or cryoablation) were compared to the PFA by means of a propensity score matching (ratio 1:1:1). Results: One-thousand one female patients (mean age 63±10 years, mean left ventricular ejection fraction 60.8±6%) were included: 376 (37.6%) underwent cryoablation ablation, 342 (34.2%) radiofrequency ablation, and 283 (28.3%) PFA. Propensity score matching yielded 684 patients (228 per group). The PFA group had significantly shorter skin-to-skin time (60 [50-75] minutes) compared with both radiofrequency (120 [90-145] minutes, P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/41676924; firstpage:1; lastpage:11; numberofpages:11; journal:JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE; https://hdl.handle.net/2434/1221315 |
| DOI: |
10.1161/JAHA.125.041873 |
| Availability: |
https://hdl.handle.net/2434/1221315; https://doi.org/10.1161/JAHA.125.041873 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.EF89B5BE |
| Database: |
BASE |