| Title: |
The NEMO/ATM/IKKα complex: A key player in colorectal cancer progression and treatment |
| Authors: |
Perkins ND |
| Source: |
Science Signaling, 11 March 2025 |
| Publication Year: |
2025 |
| Collection: |
Newcastle University Library ePrints Service |
| Description: |
The kinase IKKα phosphorylates the kinase ATM, enhancing its ability to promote DNA repair. In this issue of Science Signaling, Alonso-Marañón et al. demonstrate that in colorectal cancer cells, the IKK regulatory subunit NEMO targets the ATM/IKKα complex to sites of DNA damage, thus enhancing DNA repair and chemotherapy resistance. |
| Document Type: |
review |
| Language: |
unknown |
| Relation: |
https://eprints.ncl.ac.uk/305129 |
| Availability: |
https://eprints.ncl.ac.uk/305129 |
| Accession Number: |
edsbas.EFD07DE3 |
| Database: |
BASE |