| Title: |
Reproductive function and risk for PCOS in women treated for bipolar disorder |
| Authors: |
Rasgon, NL; Altshuler, LL; Fairbanks, L; Elman, S; Bitran, J; Labarca, R; Saad, M; Kupka, R; Nolen, WA; Frye, MA; Suppes, T; McElroy, SL; Keck, PE; Leverich, G; Grunze, H; Walden, J; Post, R; Mintz, J |
| Source: |
Rasgon, NL, Altshuler, LL, Fairbanks, L, Elman, S, Bitran, J, Labarca, R, Saad, M, Kupka, R, Nolen, WA, Frye, MA, Suppes, T, McElroy, SL, Keck, PE, Leverich, G, Grunze, H, Walden, J, Post, R & Mintz, J 2005, 'Reproductive function and risk for PCOS in women treated for bipolar disorder', Bipolar Disorders, vol. 7, no. 3, pp. 246-259. |
| Publication Year: |
2005 |
| Collection: |
University of Groningen research database |
| Subject Terms: |
bipolar disorder; hirsutism; menstrual abnormalities; polycystic ovary syndrome; weight gain; women; POLYCYSTIC-OVARY-SYNDROME; ENDOCRINE DISORDERS; EPILEPSY; VALPROATE; LAMOTRIGINE; OBESITY; ABNORMALITIES; PREVALENCE; OVERWEIGHT; THERAPY |
| Description: |
Introduction: This study examined the reproductive function and prevalence of polycystic ovary syndrome (PCOS) in women with bipolar disorder taking antimanic medications. Method: Women aged 18-45 treated for bipolar disorder and not taking steroid contraceptives were recruited to complete questionnaires about their menstrual cycle and to provide blood samples for measurement of a range of reproductive endocrine and metabolic hormone levels. Eighty women participated in completing the questionnaires and 72 of them provided blood samples. Results: Fifty-two of the 80 women (65%) reported current menstrual abnormalities, 40 of which (50%) reported one or more menstrual abnormalities that preceded the diagnosis of bipolar disorder. Fifteen women (38%) reported developing menstrual abnormalities since treatment for bipolar disorder, 14 of which developed abnormalities since treatment with valproate (p = 0.04). Of the 15 patients reporting menstrual abnormalities since starting medication, 12 (80%) reported changes in menstrual flow (heavy or prolonged bleeding) and five (33%) reported changes in cycle frequency. No significant differences were observed between women receiving or not receiving valproate in mean levels of free or total serum testosterone levels. This was true for the total sample and for the sub-group without preexisting menstrual problems. However, within the valproate group, duration of use was significantly correlated with free testosterone levels (r = 0.33, p = 0.02). Three of the 50 women (6%) taking VPA, and 0% of the 22 taking other antimanic medications, met criteria for PCOS (p = 0.20). Other reproductive and metabolic values outside the normal range across treatment groups included elevated 17 alpha-OH progesterone levels, luteinizing hormone: follicle-stimulating hormone ratios, homeostatic model assessment (HOMA) values, and low estrogen and dehydroepiandrosterone sulfate (DHEAS) levels. Preexisting menstrual abnormalities predicted higher levels of 17 alpha-OH progesterone, free ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
1398-5647 |
| Relation: |
info:eu-repo/semantics/altIdentifier/wos/000229081100004; info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/11370/2dd9d5b5-e0b6-489e-9c6d-9b0f5c5d9782; info:eu-repo/semantics/altIdentifier/pissn/1398-5647 |
| Availability: |
https://hdl.handle.net/11370/2dd9d5b5-e0b6-489e-9c6d-9b0f5c5d9782; https://research.rug.nl/en/publications/2dd9d5b5-e0b6-489e-9c6d-9b0f5c5d9782 |
| Rights: |
info:eu-repo/semantics/restrictedAccess |
| Accession Number: |
edsbas.EFD55BD9 |
| Database: |
BASE |