| Title: |
The Impact of Physical Activity on the Prevention of Type 2 Diabetes: Evidence and Lessons Learned From the Diabetes Prevention Program, a Long-Standing Clinical Trial Incorporating Subjective and Objective Activity Measures. |
| Authors: |
Kriska, Andrea M; Rockette-Wagner, Bonny; Edelstein, Sharon L; Bray, George A; Delahanty, Linda M; Hoskin, Mary A; Horton, Edward S; Venditti, Elizabeth M; Knowler, William C; Gadde, Kishore; Culbert, Iris W; Arceneaux, Jennifer; Chatellier, Annie; Dragg, Amber; Champagne, Catherine M; Duncan, Crystal; Eberhardt, Barbara; Greenway, Frank; Guillory, Fonda G; Herbert, April A; Jeffirs, Michael L; Kennedy, Betty M; Levy, Erma; Lockett, Monica; Lovejoy, Jennifer C; Morris, Laura H; Melancon, Lee E; Ryan, Donna H; Sanford, Deborah A; Smith, Kenneth G; Smith, Lisa L; St. Amant, Julia A; Tulley, Richard T; Vicknair, Paula C; Williamson, Donald; Zachwieja, Jeffery J; Polonsky, Kenneth S; Tobian, Janet; Ehrmann, David A; Matulik, Margaret J; Clark, Bart; Czech, Kirsten; DeSandre, Catherine; Hilbrich, Ruthanne; McNabb, Wylie; Semenske, Ann R; Caro, Jose F; Furlong, Kevin; Goldstein, Barry J; Watson, Pamela G; Smith, Kellie A; Mendoza, Jewel; Wildman, Wendi; Liberoni, Renee; Spandorfer, John; Pepe, Constance; Donahue, Richard P; Goldberg, Ronald B; Prineas, Ronald; Calles, Jeanette; Ojito, Juliet; Rowe, Patricia; Cassanova-Romero, Paul; Castillo-Florez, Sumaya; Florez, Hermes J; Giannella, Anna; Kirby, Lascelles; Larreal, Carmen; Lara, Olga; McLymont, Valerie; Mendez, Jadell; Perry, Arlette; Saab, Patrice; Veciana, Beth; Haffner, Steven M; Hazuda, Helen P; Montez, Maria G; Hattaway, Kathy; Lorenzo, Carlos; Martinez, Arlene; Walker, Tatiana; Dabelea, Dana; Hamman, Richard F; Nash, Patricia V; Steinke, Sheila C; Testaverde, Lisa; Anderson, Denise R; Ballonoff, Larry B; Bouffard, Alexis; Bucca, Brian; Calonge, B Ned; Delve, Lynne; Farago, Martha; Hill, James O; Hoyer, Shelley R; Jenkins, Tonya; Jortberg, Bonnie T; Lenz, Dione; Miller, Marsha |
| Source: |
Diabetes Care, vol 44, iss 1 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2021 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
32 Biomedical and Clinical Sciences (for-2020); 4206 Public Health (for-2020); 42 Health Sciences (for-2020); 3202 Clinical Sciences (for-2020); Clinical Research (rcdc); Minority Health (rcdc); Obesity (rcdc); Physical Activity (rcdc); Clinical Trials and Supportive Activities (rcdc); Health Disparities (rcdc); Prevention (rcdc); Behavioral and Social Science (rcdc); Nutrition (rcdc); Women's Health (rcdc); Diabetes (rcdc); 3.1 Primary prevention interventions to modify behaviours or promote wellbeing (hrcs-rac); Oral and gastrointestinal (hrcs-hc); Metabolic and endocrine (hrcs-hc); Stroke (hrcs-hc); Cross-Sectional Studies (mesh); Diabetes Mellitus; Type 2 (mesh); Exercise (mesh); Humans (mesh); Hypoglycemic Agents (mesh); Life Style (mesh); Metformin (mesh); DPP Research Group; 11 Medical and Health Sciences (for); Endocrinology & Metabolism (science-metrix) |
| Subject Geographic: |
43 - 49 |
| Description: |
OBJECTIVE: Across the Diabetes Prevention Program (DPP) follow-up, cumulative diabetes incidence remained lower in the lifestyle compared with the placebo and metformin randomized groups and could not be explained by weight. Collection of self-reported physical activity (PA) (yearly) with cross-sectional objective PA (in follow-up) allowed for examination of PA and its long-term impact on diabetes prevention. RESEARCH DESIGN AND METHODS: Yearly self-reported PA and diabetes assessment and oral glucose tolerance test results (fasting glucose semiannually) were collected for 3,232 participants with one accelerometry assessment 11-13 years after randomization (n = 1,793). Mixed models determined PA differences across treatment groups. The association between PA and diabetes incidence was examined using Cox proportional hazards models. RESULTS: There was a 6% decrease (Cox proportional hazard ratio 0.94 [95% CI 0.92, 0.96]; P < 0.001) in diabetes incidence per 6 MET-h/week increase in time-dependent PA for the entire cohort over an average of 12 years (controlled for age, sex, baseline PA, and weight). The effect of PA was greater (12% decrease) among participants less active at baseline ( |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt8111n02c; https://escholarship.org/uc/item/8111n02c; https://escholarship.org/content/qt8111n02c/qt8111n02c.pdf |
| DOI: |
10.2337/dc20-1129 |
| Availability: |
https://escholarship.org/uc/item/8111n02c; https://escholarship.org/content/qt8111n02c/qt8111n02c.pdf; https://doi.org/10.2337/dc20-1129 |
| Rights: |
public |
| Accession Number: |
edsbas.EFF4C4C0 |
| Database: |
BASE |