| Title: |
Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults |
| Authors: |
Bosch de Basea Gomez, Magda; Thierry-Chef, Isabelle; Harbron, Richard; Hauptmann, Michael; Byrnes, Graham; Bernier, Marie-Odile; Le Cornet, Lucian; Dabin, Jérémie; Ferro, Gilles; Istad, Tore, S; Jahnen, Andreas; Lee, Choonsik; Maccia, Carlo; Malchair, Françoise; Olerud, Hilde; Simon, Steven, L; Figuerola, Jordi; Peiro, Anna; Engels, Hilde; Johansen, Christoffer; Blettner, Maria; Kaijser, Magnus; Kjaerheim, Kristina; Berrington de Gonzalez, Amy; Journy, Neige; Meulepas, Johanna, M; Moissonnier, Monika; Nordenskjold, Arvid; Pokora, Roman; Ronckers, Cecile; Schüz, Joachim; Kesminiene, Ausrele; Cardis, Elisabeth |
| Contributors: |
Instituto de Salud Global - Institute For Global Health Barcelona (ISGlobal); Universitat Pompeu Fabra Barcelona (UPF); Spanish Consortium for Research on Epidemiology and Public Health; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health (CIBERESP); Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC); Organisation Mondiale de la Santé / World Health Organization Office Genève, Suisse (OMS / WHO); Newcastle University; Institute of Biostatistics and Registry Research, Brandenburg Medical School Theodor Fontane; International Agency for Research on Cancer (IARC); Laboratoire d épidémiologie des rayonnements ionisants (IRSN/PSE-SANTE/SESANE/LEPID); Service de recherche sur les effets biologiques et Sanitaires des rayonnements ionisants (IRSN/PSE-SANTE/SESANE); Institut de Radioprotection et de Sûreté Nucléaire (IRSN)-Institut de Radioprotection et de Sûreté Nucléaire (IRSN); German Cancer Research Center - Deutsches Krebsforschungszentrum Heidelberg (DKFZ); Institute of Medical Biostatistics, Epidemiology and Informatics; University Medical Centre Mainz; Centre d'Etude de l'Energie Nucléaire (SCK-CEN); Norwegian Radiation and Nuclear Safety Authority; Luxembourg Institute of Science and Technology (LIST); National Cancer Institute Bethesda (NCI-NIH); National Institutes of Health Bethesda, MD, USA (NIH); Division of Cancer Epidemiology and Genetics; National Cancer Institute (NCI); Centre d'Assurance qualité des Applications Technologiques dans le domaine de la Santé (CAATS); Belgian Nuclear Research Centre Mol, Belgique (SCK-CEN); Danish Cancer Society Research Center (DCSRC); University of Mainz; Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU); Karolinska University Hospital Stockholm; Cancer Registry of Norway; Centre de recherche en épidémiologie et santé des populations (CESP); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse; AP-HP. Université Paris Saclay-AP-HP. Université Paris Saclay-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay; Institut de Radioprotection et de Sûreté Nucléaire (IRSN); Institut Gustave Roussy (IGR); The Netherlands Cancer Institute Amsterdam, The Netherlands; International Agency for Research on Cancer Lyon, France; Department of Clinical Neuroscience, Division of Neurology; Karolinska Institutet = Karolinska Institute Stockholm; University Medical Center, Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI); Centre international de Recherche sur le Cancer (CIRC); The Instituto de Salud Carlos III-ISCIII from the Spanish Government (reference: PI16/00120) cofunded by FEDER funds/European Regional Development Fund (ERDF); he grant CEX2018-000806-S funded by MCIN/AEI/10.13039/501100011033, Ajouter au projet Citavi par DOI from the Generalitat de Catalunya through the CERCA Program and from the Secretariat of Universities and Research of the Department of Business and Knowledge of the Generalitat of Catalonia through AGAUR (the Catalan Agency for Management of University and Research Grants) (Project 2017 SGR 1487) to EC; The International Agency for Research in Cancer (IARC) received complementary funding from The Ministry of Health, Labour and Welfare of Japan (grant agreement number 2012-02-21-01) (A.K. and J.S.); the association ‘La Ligue contre le Cancer’ (grant number PRE09/MOB) and from the French Institute of cancer (INCa, grant number 2011–1-PL-SHS-01-IRSN-1, grant number SHS-ESP-2019-025) (M.-O.B.); the German Federal Ministry of Education and Research (grant numbers 02NUK016A, 02NUK016B and 02NUK016CX); Junior group leaders from the Dutch Cancer Society (Grant UVA2021-5517); the UK Department of Health and the US National Cancer Institute; the Norwegian Research Council through the EURATOM program, project no. 209096/E40 (K.K.). Denmark received complementary funding from the Danish Cancer Society (C.J.); GTR IRSN - Utilisation sûre et optimisée des Rayonnements ionisants en médecine (D3P13); European Project: 269912,FP7-Fission-2010,FP7-Fission-2010,EPI-CT(2011) |
| Source: |
ISSN: 1078-8956. |
| Publisher Information: |
CCSD; Nature Publishing Group |
| Publication Year: |
2023 |
| Collection: |
Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| Subject Terms: |
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| Description: |
Author Correction: Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults : 10.1038/s41591-025-03689-5 ; International audience ; Over one million European children undergo computed tomography (CT) scans annually. Although moderate- to high-dose ionizing radiation exposure is an established risk factor for hematological malignancies, risks at CT examination dose levels remain uncertain. Here we followed up a multinational cohort (EPI-CT) of 948,174 individuals who underwent CT examinations before age 22 years in nine European countries. Radiation doses to the active bone marrow were estimated on the basis of body part scanned, patient characteristics, time period and inferred CT technical parameters. We found an association between cumulative dose and risk of all hematological malignancies, with an excess relative risk of 1.96 (95% confidence interval 1.10 to 3.12) per 100 mGy (790 cases). Similar estimates were obtained for lymphoid and myeloid malignancies. Results suggest that for every 10,000 children examined today (mean dose 8 mGy), 1–2 persons are expected to develop a hematological malignancy attributable to radiation exposure in the subsequent 12 years. Our results strengthen the body of evidence of increased cancer risk at low radiation doses and highlight the need for continued justification of pediatric CT examinations and optimization of doses. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/37946058; info:eu-repo/grantAgreement//269912/EU/Epidemiological study to quantify risks for paediatric computerized tomography and to optimise doses./EPI-CT; PUBMED: 37946058; PUBMEDCENTRAL: PMC10719096 |
| DOI: |
10.1038/s41591-023-02620-0 |
| Availability: |
https://asnr.hal.science/irsn-04399853; https://asnr.hal.science/irsn-04399853v1/document; https://asnr.hal.science/irsn-04399853v1/file/s41591-023-02620-0.pdf; https://doi.org/10.1038/s41591-023-02620-0 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.EFFA8EE5 |
| Database: |
BASE |