| Title: |
Autoimmune Hepatitis—Immunologically Triggered Liver Pathogenesis—Diagnostic and Therapeutic Strategies |
| Authors: |
Sucher, Elisabeth; Sucher, Robert; Gradistanac, Tanja; Brandacher, Gerald; Schneeberger, Stefan; Berg, Thomas |
| Contributors: |
Universität Leipzig; Deutsche Forschungsgemeinschaft |
| Source: |
Journal of Immunology Research ; volume 2019, page 1-19 ; ISSN 2314-8861 2314-7156 |
| Publisher Information: |
Wiley |
| Publication Year: |
2019 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Autoimmune hepatitis (AIH) is a severe liver disease that arises in genetically predisposed male and female individuals worldwide. Diagnosis of AIH is made clinically applying diagnostic scores; however, the heterotopic disease phenotype often makes a rapid determination of disease challenging. AIH responds favorably to steroids and pharmacologic immunosuppression, and liver transplantation is only necessary in cases with acute liver failure or end-stage liver cirrhosis. Recurrence or development of de novo AIH after transplantation is possible, and treatment is similar to standard AIH therapy. Current experimental investigations of T cell-mediated autoimmune pathways and analysis of changes within the intestinal microbiome might advance our knowledge on the pathogenesis of AIH and trigger a spark of hope for novel therapeutic strategies. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1155/2019/9437043 |
| Availability: |
https://doi.org/10.1155/2019/9437043; http://downloads.hindawi.com/journals/jir/2019/9437043.pdf; http://downloads.hindawi.com/journals/jir/2019/9437043.xml |
| Rights: |
http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.EFFD4FA0 |
| Database: |
BASE |