| Title: |
Vasodilator drugs and heart-related outcomes in systemic sclerosis: an exploratory analysis. |
| Authors: |
Guédon, A. F.; Carrat, F.; Mouthon, L.; Launay, David; Chaigne, B.; Pugnet, G.; Lega, J. C.; Hot, A.; Cottin, V.; Agard, C.; Allanore, Y.; Fauchais, A. L.; Lescoat, A.; Dhote, R.; Papo, T.; Chatelus, E.; Bonnotte, B.; Kahn, J. E.; Diot, E.; Aouba, A.; Magy-Bertrand, N.; Queyrel, V.; Le Quellec, A.; Kieffer, P.; Amoura, Z.; Granel, B.; Gaultier, J. B.; Balquet, M. H.; Wahl, D.; Lidove, O.; Espitia, O.; Cohen, A.; Fain, O.; Hachulla, Eric; Mekinian, A.; Rivière, S. |
| Contributors: |
Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP); Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU); CHU Saint-Antoine AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); Hôpital Cochin AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Centre de référence des maladies auto-immunes et auto-inflammatoires systémiques rares de l'adulte d'Île de France, Est et Ouest / Reference center for rare systemic autoimmune and autoinflammatory diseases in adults in Île-de-France, East and West (CRMR); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille); Centre Hospitalier Universitaire de Toulouse (CHU Toulouse); Hospices Civils de Lyon (HCL); Centre de Référence des Maladies Pulmonaires Rares Hôpital Louis Pradel - HCL; Hôpital Louis Pradel CHU - HCL; Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL); Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes); Centre Hospitalier Universitaire Dupuytren 1 et 2 (CHU Limoges); CHU Limoges; Centre Hospitalier Universitaire Rennes; Centre Hospitalier Régional Universitaire de Tours (CHRU Tours); AP-HP - Hôpital Bichat - Claude Bernard Paris; Centre Hospitalier Universitaire Strasbourg (CHU Strasbourg); Hôpitaux Universitaires de Strasbourg (HUS); Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon); Hôpital Ambroise Paré AP-HP; CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie (CHU Caen Normandie); Normandie Université (NU); Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon); Centre Hospitalier Universitaire de Nice (CHU Nice); Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); Groupe hospitalier de la région de Mulhouse et Sud-Alsace; CHU Pitié-Salpêtrière AP-HP; Assistance Publique - Hôpitaux de Marseille (APHM); Centre Hospitalier Universitaire de Saint-Etienne CHU Saint-Etienne (CHU ST-E); Centre Hospitalier de Lens; Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy); Groupe Hospitalier Diaconesses Croix Saint-Simon |
| Source: |
EISSN: 2056-5933 ; RMD Open ; https://lilloa.hal.science/hal-04872491 ; RMD Open, 2024, RMD Open, 10, ⟨10.1136/rmdopen-2024-004918⟩ |
| Publisher Information: |
CCSD; BMJ Publishing Group |
| Publication Year: |
2024 |
| Collection: |
LillOA (HAL Lille Open Archive, Université de Lille) |
| Subject Terms: |
Cardiovascular Diseases; Machine Learning; Systemic Sclerosis; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Background and aims: Systemic sclerosis (SSc) is an autoimmune connective disease characterised by excessive extracellular matrix deposition and widespread skin and internal organ fibrosis including various cardiac manifestations. Heart involvement is one of the leading causes of death among patients with SSc. In this study, we aimed to assess the effect of various vasodilator treatments.Methods: We used data from a national multicentric prospective study using the French SSc national database. We estimated the average treatment effect (ATE) of sildenafil, bosentan, angiotensin-converting enzyme (ACE) inhibitors and iloprost on diastolic dysfunction, altered ejection fraction |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/39658051; PUBMED: 39658051 |
| DOI: |
10.1136/rmdopen-2024-004918 |
| Availability: |
https://lilloa.hal.science/hal-04872491; https://lilloa.hal.science/hal-04872491v1/document; https://lilloa.hal.science/hal-04872491v1/file/e004918.full.pdf; https://doi.org/10.1136/rmdopen-2024-004918 |
| Rights: |
https://creativecommons.org/licenses/by-nc/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.F012B5F9 |
| Database: |
BASE |