| Title: |
Evaluating glomerular filtration rate slope as a surrogate end point for ESKD in clinical trials: An individual participant meta-analysis of observational data |
| Authors: |
Grams, ME; Sang, Y; Ballew, SH; Matsushita, K; Astor, BC; Carrero, JJ; Chang, AR; Inker, LA; Kenealy, T; Kovesdy, CP; Lee, BJ; Levin, A; Naimark, D; Pena, MJ; Schold, JD; Shalev, V; Wetzels, JFM; Woodward, M; Gansevoort, RT; Levey, AS; Coresh, J |
| Source: |
urn:ISSN:1046-6673 ; urn:ISSN:1533-3450 ; Journal of the American Society of Nephrology, 30, 9, 1746-1755 |
| Publisher Information: |
Wolters Kluwer |
| Publication Year: |
2019 |
| Collection: |
UNSW Sydney (The University of New South Wales): UNSWorks |
| Subject Terms: |
32 Biomedical and Clinical Sciences; 3202 Clinical Sciences; Clinical Research; Clinical Trials and Supportive Activities; Health Disparities and Racial or Ethnic Minority Health Research; 3 Good Health and Well Being; Biomarkers; Disease Progression; Glomerular Filtration Rate; Humans; Kidney Failure; Chronic; Observational Studies as Topic; Predictive Value of Tests; Randomized Controlled Trials as Topic; Renal Replacement Therapy; chronic kidney disease; end-stage renal disease; progression of chronic renal failure; anzsrc-for: 32 Biomedical and Clinical Sciences; anzsrc-for: 3202 Clinical Sciences; anzsrc-for: 1103 Clinical Sciences |
| Description: |
Background Decline in eGFR is a biologically plausible surrogate end point for the progression of CKD in clinical trials. However, it must first be tested to ensure strong associations with clinical outcomes in diverse populations, including patients with higher eGFR. Methods To investigate the association between 1-, 2-, and 3-year changes in eGFR (slope) with clinical outcomes over the long term, we conducted a random effects meta-analysis of 3,758,551 participants with baseline eGFR≥60 ml/min per 1.73 m 2 and 122,664 participants with eGFR |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
https://hdl.handle.net/1959.4/unsworks_67138; https://doi.org/10.1681/ASN.2019010008 |
| DOI: |
10.1681/ASN.2019010008 |
| Availability: |
https://hdl.handle.net/1959.4/unsworks_67138; https://unsworks.unsw.edu.au/bitstreams/5f49dbc3-a9eb-480a-8fb2-59eb0659b6fd/download; https://doi.org/10.1681/ASN.2019010008 |
| Rights: |
open access ; https://purl.org/coar/access_right/c_abf2 ; CC-BY-NC-ND ; https://creativecommons.org/licenses/by-nc-nd/4.0/ ; free_to_read |
| Accession Number: |
edsbas.F02B13C3 |
| Database: |
BASE |