| Title: |
Low-level viral loads and virological failure in the integrase strand transfer era |
| Authors: |
Cuzin, Lise; Flandre, Philippe; Allavena, Clotilde; Palich, Romain; Duvivier, Claudine; Becker, Agathe; Laroche, Hélène; Pugliese, Pascal; Cabie, André; Chirouze, C; Babre, O; Bouiller, K; Bozon, F; Brunel, A; Chevalier, E; Hustache-Mathieu, L; Lagoutte, J; Lepiller, Q; Marty-Quinternet, S; Muret, P; Rosolen, B; Tissot, N; Jaffuel, S; Jacomet, C; Aumeran, C; Baud, O; Brebion, A; Corbin, V; Goncalvez, E; Henquell, C; Laurichesse, H; Lesens, O; Mazzocolin, D; Mirand, A; Mrozek, N; Theis, C; Vidal, M; Lamaury, I; Bissuel, F; Boulard, F; Curlier, E; Fabre, I; Halley, E; Herrmann-Storck, C; Le Guillou, C; Markowicz, S; Marquet, M; Ouissa, R; Receveur, M; Reltien, J; Roger, P; Tressieres, B; Merrien, D; Bollangier, O; Boucher, D; Guimard, T; Laine, L; Leautez, S; Morrier, M; Perré, P; Point, P; Faucher, J; Cypierre, A; Ducroix-Roubertou, S; Durox, H; Genet-Villeger, C; Pascual, J; Pinet, P; Rogez, S; Woillard, J; Cotte, L; Ader, F; Alfaiate, D; Boibieux, A; Brochier, C; Brunel-Dalmas, F; Cannesson, O; Chiarello, P; Chidiac, C; Conrad, A; Degroodt, S; Ferry, T; Godinot, M; Icard, V; Livrozet, J; Makhloufi, D; Perpoint, T; Perry, M; Pouderoux, C; Roux, S; Trabaud, M; Triffault-Fillit, C; Valour, F; Ravaux, I; Ménard, A; Aherfi, S; Amrane, S; Belkhir, A; Colson, P; Dhiver, C; Martin-Degioanni, M; Meddeb, L; Mokhtari, M; Motte, A; Tissot-Dupont, H; Toméi, C; Poizot-Martin, I; Brégigeon, S; Ducassou, M; Galie, S; Ivanova, A; Jaquet, I; Obry-Roguet, V; Orticoni, M; Ressiot, E; Ritleng, A; Rojas-Rojas, T; Zaegel-Faucher, O; Abel, S; Bavay, J; Bigeard, B; Cabras, O; Dupin de Majoubert, R; Fagour, L; Guitteaud, K; Lehoux, M; Montagnac, C; Pierre-François, S; Rome, K; Turmel, J; Reynes, J; Atoui, N; Bistoquet, M; Delaporte, E; Le Moing, V; Lejeune, J; Makinson, A; Meftah, N; Merle de Boever, C; Montes, B; Montoya Ferrer, A; Tuaillon, E; Lefèvre, B; André, M; Baronnet, G; Bevilacqua, S; Boyer, L; Bouillon, M; Charmillon, A; Delestan, M; Frentiu, E; Goehringer, F; Hénard, S; Jeanmaire, E; Rabaud, C; Radjabaly-Mandjee, A; Raffi, F; André-Garnier, E; Asquier-Khati, A; Billaud, E; Biron, C; Bonnet, B; Bouchez, S; Boutoille, D; Brunet-Cartier, C; Cavellec, M; Deschanvres, C; Ferré, V; Gaborit, B; Grégoire, A; Grégoire, M; Jovelin, T; Lefebvre, M; Lecomte, R; Mahot, R; Morineau, P; Paredes, E; Reliquet, V; Sécher, S; Soria, A; Bréaud, S; Buscot, M; Carles, M; Chirio, D; Cua, E; Dellamonica, P; Demonchy, E; de Monte, A; Durant, J; Ferrando, S; Garraffo, R; Michelangeli, C; Naqvi, A; Perbost, I; Pradier, C; Prouvost-Keller, B; Risso, K; Touitou, I; Viot, A; Wehrlen-Pugliese, S; Hocqueloux, L; Gubavu, C; Legros, V; Peira, F; Prazuck, T; Rzepecki, V; Sève, A; Cheret, A; Barrail-Tran, A; Castro, A; Colarino, R; Goujard, C; Jaureguiberry, S; Quertainmont, Y; Teicher, E; Joly, V; Charpentier, C; Descamps, D; Digumber, M; Gervais, A; Ghosn, J; Julia, Z; Landman, R; Lariven, S; Le Gac, S; Louni, F; Peytavin, G; Rioux, C; Yazdanpanah, Y; Amazzough, K; Benabdelmoumen, G; Bossi, P; Cessot, G; Charlier, C; Consigny, P; Gomes-Pires, E; Jidar, K; Lafont, E; Lanternier, F; Lortholary, O; Louisin, C; Lourenco, J; Melenotte, C; Parize, P; Pouvaret, A; Rouzaud, C; Serris, A; Touam, F; Katlama, C; Agher, R; Blanc, C; Dudoit, Y; Hamani, N; Qatib, N; Qzaibri, I; Lenclume, L; Schneider, L; Seang, S; Tubiana, R; Valantin, M; Bani-Sadr, F; Bermejo, M; Berger, J; Demotier, S; Hentzien, M; Julien, G; Kmiec, I; Lambert, D; Marty, H; N’guyen, Y; Romaru, J; Arvieux, C; Baldeyrou, M; Benezit, F; Chapplain, J; Dupont, M; Duthé, J; Lebot, A; Lemaitre, F; Maillard, A; Morlat, C; Patrat-Delon, S; Poisson-Vannier, M; Pronier, C; Revest, M; Sinteff, J; Souala, F; Tattevin, P; Gagneux-Brunon, A; Botelho-Nevers, E; Frésard, A; Lucht, F; Ronat, V; Rey, D; Cheneau, C; Bernard-Henry, C; de Mautort, E; Fafi-Kremer, S; Fischer, P; Gantner, P; Mélounou, C; Partisani, M; Delobel, P; Alvarez, M; Biezunski, N; Debard, A; Delpierre, C; Garnier, C; Gaube, G; Lelièvre, L; Marcel, M; Martin-Blondel, G; Piffaut, M; Porte, L; Saune, K; Robineau, O; Aïssi, E; Ajana, F; Alcaraz, I; Alidjinou, E; Baclet, V; Bocket, L; Boucher, A; Derdour, V; Gilbert, M; Huleux, T; Lafon-Desmurs, B; Meybeck, A; Pradier, M; Tetart, M; Thill, P; Valette, M; Viget, N; Corvaisier, G |
| Contributors: |
Equipe EQUITY (CERPOP); Centre d'Epidémiologie et de Recherche en santé des POPulations (CERPOP); Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM); Centre Hospitalier Universitaire de Martinique Fort-de-France, Martinique (CHU de Martinique); Environnement, Mobilité et Santé iPLesp (NEMESIS); Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP); Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU); Service des maladies infectieuses et tropicales CHU Nantes; Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes); Service des Maladies infectieuses et tropicales CHU Necker; Hôpital Necker - Enfants Malades AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Institut Cochin (IC UM3 (UMR 8104 / U1016)); Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité); Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité); Service des Maladies Infectieuses et Tropicales Lyon; Hôpital de la Croix-Rousse CHU - HCL; Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL); Service d'Immuno-hématologie clinique Hôpital Sainte Marguerite - APHM; Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital Sainte-Marguerite CHU - APHM (Hôpitaux Sud); Service d'infectiologie CHU Nice; Centre Hospitalier Universitaire de Nice (CHU Nice); Pathogenesis and Control of Chronic and Emerging Infections (PCCEI); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles (UA)-Établissement Français du Sang Montpellier (EFS - Montpellier); Établissement Français du Sang La Plaine Saint-Denis (EFS)-Établissement Français du Sang La Plaine Saint-Denis (EFS)-Université de Montpellier (UM); Laboratoire Microorganismes : Génome et Environnement (LMGE); Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA); Service Hygiène Hospitalière CHU Clermont-Ferrand; Pôle RHEUNNIRS CHU Clermont-Ferrand; CHU Gabriel Montpied Clermont-Ferrand; CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Gabriel Montpied Clermont-Ferrand; CHU Clermont-Ferrand-CHU Clermont-Ferrand; Université Clermont Auvergne (UCA); CHU Clermont-Ferrand |
| Source: |
ISSN: 0305-7453. |
| Publisher Information: |
CCSD; Oxford University Press (OUP) |
| Publication Year: |
2023 |
| Collection: |
Université Toulouse III - Paul Sabatier: HAL-UPS |
| Subject Terms: |
MESH: Anti-HIV Agents* / therapeutic use; MESH: HIV Infections; MESH: Humans; MESH: Integrases; MESH: Proportional Hazards Models; MESH: Treatment Failure; MESH: Viral Load; [SDV]Life Sciences [q-bio]; [SDV.IMM]Life Sciences [q-bio]/Immunology; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology; [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases |
| Description: |
International audience ; Objectives: To analyse the occurrence of virological failure (VF) in patients starting ART with an integrase strand transfer inhibitor (INSTI)-based regimen in recent years, in relation with previous episodes of low-level viral load (LLVL).Patients and methods: Patients starting a first ART between 1 January 2015 and 31 December 2020 based on two NRTIs and one INSTI were included if after virological control (two measures of VL < 50 copies/mL) they had a minimum of two additional VL measurements. Cox models adjusted for sex, age, acquisition group, hepatitis B or C coinfection, place of birth, year of ART initiation, CD4+ T cells and VL at ART initiation, duration of known HIV infection and of ART regimen were used to assess the association between the time to VF and the occurrence of LLVL. ART regimen was evaluated as time-varying covariate.Results: LLVL was described in 13.7% and VF in 11% of the 3302 patients. LLVL was associated with VF [adjusted HR (aHR) 1.76, 95% CI 1.28-2.41], as well as age (aHR 0.97/year, 95% CI 0.96-0.98), CD4+ T cell count at ART initiation (aHR 0.93, 95% CI 0.87-0.98), heterosexual transmission (aHR 1.76, 95% CI 1.30-2.37) and being born abroad (aHR 1.50, 95% CI 1.17-1.93).Conclusions: LLVL was related to VF. Even in the absence of subsequent failure, LLV episodes have a cost. Thus any VL value above 50 copies/mL should lead to enhanced adherence counselling. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/36879512; PUBMED: 36879512 |
| DOI: |
10.1093/jac/dkad056 |
| Availability: |
https://hal.science/hal-04028835; https://doi.org/10.1093/jac/dkad056 |
| Accession Number: |
edsbas.F02FAE99 |
| Database: |
BASE |