| Title: |
Characterisation of Fasting and Postprandial NMR Metabolites: Insights from the ZOE PREDICT 1 Study |
| Authors: |
Bermingham K. M.; Mazidi M.; Franks P. W.; Maher T.; Valdes A. M.; Linenberg I.; Wolf J.; Hadjigeorgiou G.; Spector T. D.; Menni C.; Ordovas J. M.; Berry S. E.; Hall W. L. |
| Contributors: |
K.M. Bermingham; M. Mazidi; P.W. Frank; T. Maher; A.M. Valde; I. Linenberg; J. Wolf; G. Hadjigeorgiou; T.D. Spector; C. Menni; J.M. Ordova; S.E. Berry; W.L. Hall |
| Publisher Information: |
MDPI |
| Publication Year: |
2023 |
| Collection: |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: |
lipid; lipoprotein; nuclear magnetic resonance (NMR); Settore MED/01 - Statistica Medica |
| Description: |
Background: Postprandial metabolomic profiles and their inter-individual variability are not well characterised. Here, we describe postprandial metabolite changes, their correlations with fasting values and their inter- and intra-individual variability, following a standardised meal in the ZOE PREDICT 1 cohort. Methods: In the ZOE PREDICT 1 study (n = 1002 (NCT03479866)), 250 metabolites, mainly lipids, were measured by a Nightingale NMR panel in fasting and postprandial (4 and 6 h after a 3.7 MJ mixed nutrient meal, with a second 2.2 MJ mixed nutrient meal at 4 h) serum samples. For each metabolite, inter- and intra-individual variability over time was evaluated using linear mixed modelling and intraclass correlation coefficients (ICC) were calculated. Results: Postprandially, 85% (of 250 metabolites) significantly changed from fasting at 6 h (47% increased, 53% decreased; Kruskal–Wallis), with 37 measures increasing by >25% and 14 increasing by >50%. The largest changes were observed in very large lipoprotein particles and ketone bodies. Seventy-one percent of circulating metabolites were strongly correlated (Spearman’s rho >0.80) between fasting and postprandial timepoints, and 5% were weakly correlated (rho |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/37299601; info:eu-repo/semantics/altIdentifier/wos/WOS:001005672300001; volume:15; issue:11; firstpage:1; lastpage:15; numberofpages:15; journal:NUTRIENTS; https://hdl.handle.net/2434/1092031 |
| DOI: |
10.3390/nu15112638 |
| Availability: |
https://hdl.handle.net/2434/1092031; https://doi.org/10.3390/nu15112638 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.F0399288 |
| Database: |
BASE |