| Title: |
Biomarkers associated with early stages of kidney disease in adolescents with type 1 diabetes |
| Authors: |
Marcovecchio, ML; Colombo, M; Dalton, RN; McKeigue, PM; Benitez-Aguirre, P; Cameron, FJ; Chiesa, ST; Couper, JJ; Craig, ME; Daneman, D; Davis, EA; Deanfield, JE; Donaghue, KC; Jones, TW; Mahmud, FH; Marshall, SM; Neil, A; Colhoun, HM; Dunger, DB; Acerini, CL; Ackland, F; Anand, B; Barrett, T; Birrell, V; Campbell, F; Charakida, M; Cheetham, T; Cooper, C; Doughty, I; Dutta, A; Edge, J; Gray, A; Hamilton-Shield, J; Mann, N; Loredana Marcovecchio, M; Andrew, H; Neil, W; Rayman, G; Robinson, JM; Russell-Taylor, M; Sankar, V; Smith, A; Thalange, N; Yaliwal, C; Cotterill, A; Davis, E; Donaghue, K; King, B; Verge, C; Bergman, P; Rodda, C; Clarson, C; Curtis, J; Sochett, E; Chalmers, J; Collier, A; Fischbacher, C; Green, F; Lindsay, R; McKnight, J; MacRury, S; Palmer, C; Patrick, A; Pearson, D; Petrie, J; Thekkepat, S |
| Publisher Information: |
WILEY |
| Publication Year: |
2020 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
OBJECTIVES: To identify biomarkers of renal disease in adolescents with type 1 diabetes (T1D) and to compare findings in adults with T1D. METHODS: Twenty-five serum biomarkers were measured, using a Luminex platform, in 553 adolescents (median [interquartile range] age: 13.9 [12.6, 15.2] years), recruited to the Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial. Associations with baseline and final estimated glomerular filtration rate (eGFR), rapid decliner and rapid increaser phenotypes (eGFR slopes 3 mL/min/1.73m2 /year, respectively), and albumin-creatinine ratio (ACR) were assessed. Results were also compared with those obtained in 859 adults (age: 55.5 [46.1, 64.4) years) from the Scottish Diabetes Research Network Type 1 Bioresource. RESULTS: In the adolescent cohort, baseline eGFR was negatively associated with trefoil factor-3, cystatin C, and beta-2 microglobulin (B2M) (B coefficient[95%CI]: -0.19 [-0.27, -0.12], P = 7.0 × 10-7 ; -0.18 [-0.26, -0.11], P = 5.1 × 10-6 ; -0.12 [-0.20, -0.05], P = 1.6 × 10-3 ), in addition to clinical covariates. Final eGFR was negatively associated with osteopontin (-0.21 [-0.28, -0.14], P = 2.3 × 10-8 ) and cystatin C (-0.16 [-0.22, -0.09], P = 1.6 × 10-6 ). Rapid decliner phenotype was associated with osteopontin (OR: 1.83 [1.42, 2.41], P = 7.3 × 10-6 ), whereas rapid increaser phenotype was associated with fibroblast growth factor-23 (FGF-23) (1.59 [1.23, 2.04], P = 2.6 × 10-4 ). ACR was not associated with any of the biomarkers. In the adult cohort similar associations with eGFR were found; however, several additional biomarkers were associated with eGFR and ACR. CONCLUSIONS: In this young population with T1D and high rates of hyperfiltration, osteopontin was the most consistent biomarker associated with prospective changes in eGFR. FGF-23 was associated with eGFR increases, whereas trefoil factor-3, cystatin C, and B2M were associated with baseline eGFR. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
1399-543X |
| Relation: |
https://hdl.handle.net/11343/252547 |
| Availability: |
https://hdl.handle.net/11343/252547 |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0 ; CC BY-NC-ND |
| Accession Number: |
edsbas.F04AD2FE |
| Database: |
BASE |