| Title: |
Calcitonin measurement in aspiration needle washout fluids has higher sensitivity than cytology in detecting medullary thyroid cancer: a retrospective multicentre study |
| Authors: |
Pierpaolo Trimboli; Nadia Cremonini; Luca Ceriani; Enrico Saggiorato; Leo Guidobaldi; Francesco Romanelli; Claudio Ventura; Oriana Laurenti; Ilaria Messuti; Erica Solaroli; Raffaele Madaio; Massimo Bongiovanni; Anna Crescenzi; Stefano Valabrega; Luca Giovanella; ORLANDI, Fabio |
| Contributors: |
Pierpaolo Trimboli; Nadia Cremonini; Luca Ceriani; Enrico Saggiorato; Leo Guidobaldi; Francesco Romanelli; Claudio Ventura; Oriana Laurenti; Ilaria Messuti; Erica Solaroli; Raffaele Madaio; Massimo Bongiovanni; Fabio Orlandi; Anna Crescenzi; Stefano Valabrega; Luca Giovanella |
| Publication Year: |
2014 |
| Collection: |
Università degli studi di Torino: AperTo (Archivio Istituzionale ad Accesso Aperto) |
| Subject Terms: |
aspiration needle; calcitonin; medullary throid cancer |
| Description: |
Objective Only few studies analysed the capability of cytology in detecting medullary thyroid cancer (MTC), and they reported a low accuracy of this diagnostic technique. Recently, calcitonin (CT) measurement in aspiration needle washout (FNA-CT) of thyroid and neck lesions has been reported as a sensitive tool for MTC. The aim of this study is to compare the sensitivity of FNA-CT and cytology in detecting MTC and to assess a cut-off value of FNA-CT for clinical practice. Patients Thirty-eight MTC lesions from 36 patients were retrospectively studied, diagnosed and treated in four different centres. Furthermore, 52 nonmedullary lesions from subjects undergone biopsy following increased serum CT were collected as a control group. Results Cytology detected MTC in 21/37 lesions with 56.8% sensitivity. The median FNA-CT value was 2000 pg/ml (range 58-10000 pg/ml) in MTC and 2.7 pg/ml (range |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/23627255; info:eu-repo/semantics/altIdentifier/wos/WOS:000327801300019; volume:80; issue:1; firstpage:135; lastpage:140; numberofpages:6; journal:CLINICAL ENDOCRINOLOGY; http://hdl.handle.net/2318/144838; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84889593393 |
| DOI: |
10.1111/cen.12234 |
| Availability: |
http://hdl.handle.net/2318/144838; https://doi.org/10.1111/cen.12234 |
| Accession Number: |
edsbas.F04BBF10 |
| Database: |
BASE |