| Title: |
Fatigue levels and associated factors in systemic sclerosis: a cross-sectional study of 2385 SPIN Cohort participants |
| Authors: |
Kwakkenbos, Linda; Levis, Brooke; Henry, Richard S; Virgili-Gervais, Gabrielle; Carrier, Marie-Eve; Bartlett, S. J.; Gietzen, A.; Gottesman, K.; Guillot, G.; Lawrie-Jones, A.; Hummers, L. K.; Malcarne, V. L.; Mayes, M. D.; Richard, M.; Wojeck, R. K.; Worron-Sauvé, M.; Hudson, M.; Mouthon, L.; Benedetti, A.; Thombs, B. D.; Adams, C. E.; El-Baalbaki, G.; Fligelstone, K.; Frech, T.; Harel, D.; Hinchcliff, M.; Johnson, S. R.; Larche, M.; Leite, C.; Nguyen, C.; Nielsen, K.; Pope, J.; Rannou, F.; Rodriguez-Reyna, T. S.; Schouffoer, A. A.; Suarez-Almazor, M. E.; Agard, C.; Alric, L.; Andre, M.; Beaslay, F.; Bernstein, E. J.; Berthier, S.; Bissonnette, L.; Blaise, S.; Bories, E.; Bruns, A.; Cacciatore, C.; Carreira, P.; Casadevall, M.; Chaigne, B.; Chung, L. R. D.; Crichi, B.; Deltombe, T.; Denton, C.; Desroche, T.; Domsic, R.; Dunne, J.; Dunogue, B.; Fare, R.; Farge-Bancel, D.; Fortin, P. R.; Gauzere, L.; Gerber, A.; Gordon, J. K.; Granel-Rey, B.; Guffroy, A.; Gyger, G.; Hachulla, E.; Hoa, S.; Hughes, M.; Ikic, A.; Khalidi, N.; Lakin, K. S.; Lambert, Marc; Launay, David; Lee, Y. C.; Legendre, P.; Maillard, H.; Maltez, N.; Manning, J.; Marie, I.; Lopez, M. M.; Martin, T.; Masetto, A.; Mekinian, A.; Diaz, S. M.; Mourguet, M.; Nikpour, M.; Olagne, L.; Poindron, V.; Proudman, S.; Pugnet, G.; Raffray, L.; Regent, A.; Renou, F.; Riviere, S.; Robinson, D.; Almazar, E. R.; Roux, S.; Smets, P.; Sobanski, V.; Spiera, R. F.; Steen, V.; Sutton, E.; Thorne, C.; Vagner, D.; Varga, J.; Wilcox, P.; Ayala, M. C.; Cook, V.; Santo, C. D.; Dal Santo, T.; d'Onofrio, M.; Hu, S. P.; Nassar, E. L.; Neyer, M. A.; Provencher, S. |
| Contributors: |
Radboud University Nijmegen; Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE); Institut Pasteur de Lille; Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille); Institute for Translational Research in Inflammation - U 1286 (INFINITE); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille) |
| Source: |
ISSN: 1462-0324. |
| Publisher Information: |
CCSD; Oxford University Press (OUP) |
| Publication Year: |
2024 |
| Collection: |
LillOA (HAL Lille Open Archive, Université de Lille) |
| Subject Terms: |
[SDV]Life Sciences [q-bio] |
| Description: |
International audience ; ObjectivesThe objectives of this study were to compare fatigue in a large multinational SSc cohort with general population data and identify associated sociodemographic, lifestyle and SSc disease factors.MethodsScleroderma Patient-centered Intervention Network Cohort participants completed the Patient-Reported Outcomes Measurement Information System-29 v2.0 fatigue domain. T-scores were compared with the USA general population (mean = 50; s.d. = 10). Multivariable linear regression was used to assess associations with sociodemographic, lifestyle, and disease-related variables.ResultsAmong the 2385 participants [mean age 54.9 (s.d. = 12.6) years, 87% female, 38% dcSSc], the mean fatigue T-score was 54.6 (s.d. = 11.0); 438 (18%) reported mild fatigue, 641 (27%) moderate fatigue, and 180 (8%) severe fatigue. Fatigue was independently associated with sociodemographic factors age [−0.10 points per year, (95% CI −0.14, −0.07)], male sex [−1.67 points, (−2.96, −0.37)], non-married status [0.97 points (0.04, 1.89)] and country [reference USA; France −2.35 points (−3.48, −1.21) and UK 2.38 points (0.80, 3.97)], and lifestyle factors smoking [4.16 points (2.52, 5.80)], alcohol consumption [−0.18 points per drink per week (−0.28, −0.07)] and BMI [0.34 points per unit (0.27, 0.42)]. Fatigue was associated with disease-related factors, including gastrointestinal involvement [4.21 points (2.99, 5.43)], digital ulcers [1.51 points, (0.25, 2.77)], moderate small joint contractures (1.41 points [0.13, 2.69]), RA [4.34 points (2.37, 6.31)] and SS [1.89 points (0.23, 3.55)]. When pain was included in the model, its association was large [2.19 points (2.03, 2.34)], and interstitial lung disease was also associated [1.21 points (0.42, 2.00)].ConclusionIn people with SSc, fatigue scores were substantially higher than in the general population and associated with multiple disease factors, including gastrointestinal involvement, several painful disease manifestations, and lung involvement. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/39447026; PUBMED: 39447026 |
| DOI: |
10.1093/rheumatology/keae570 |
| Availability: |
https://hal.univ-lille.fr/hal-05325496; https://hal.univ-lille.fr/hal-05325496v1/document; https://hal.univ-lille.fr/hal-05325496v1/file/keae570.pdf; https://doi.org/10.1093/rheumatology/keae570 |
| Rights: |
http://creativecommons.org/licenses/by-nc/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.F071B476 |
| Database: |
BASE |