TIME to SEIZURE OCCURRENCE and DAMAGE in PROFILE, a MULTIETHNIC SLE COHORT
| Title: | TIME to SEIZURE OCCURRENCE and DAMAGE in PROFILE, a MULTIETHNIC SLE COHORT |
|---|---|
| Authors: | Rosalind Ramsey-goldman; Dr. P. H; Graciela S. Alarcón; Ph. D; Michelle Petri; Luis M. Vilá; Jeffrey C. Edberg; John D. Reveille; Robert P. Kimberly; M. D. Profile; Study Group |
| Contributors: | The Pennsylvania State University CiteSeerX Archives |
| Source: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787620/pdf/nihms158030.pdf. |
| Collection: | CiteSeerX |
| Description: | The objective of this study was to determine risk factors predicting seizures and damage due to seizures in a multi-ethnic systemic lupus erythematosus (SLE) cohort (PROFILE) which includes SLE patients (n=1295) from five different US institutions. Only patients with seizures after SLE diagnosis (incident) were included in the analyses of clinical seizures, 80/1295, 6.2%; but all patients (prevalent and incident) in the analyses of damage due to seizures 51/1295, 3.9%. We examined socioeconomic-demographic, clinical and genetic variables predictive of clinical seizures and damage from seizures by Cox Proportional Hazard Ratios (HR) and 95 % Confidence Intervals (CI). Independent predictors of a shorter time to occurrence of clinical seizures were younger age (HR=1.0; 95 % CI 0.9–1.0), having Hispanic-Texan ethnicity (HR=2.7; 95 % CI 1.3–5.7) or African-American ethnicity (HR=1.8; 95 % CI 1.0–3.1, and the prior occurrence of a cerebrovascular accident [CVA] (HR=3.3; 95 % CI 1.6–7.1) or an episode of psychosis (HR=2.4; 95 % CI 1.1–5.0), while the prior occurrence of photosensitivity (HR=0.5; 95 % CI 0.3–0.9).was the only independent predictor of a longer time to the clinical occurrence of seizures Independent predictors of a shorter time to |
| Document Type: | text |
| File Description: | application/pdf |
| Language: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.650.3598; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787620/pdf/nihms158030.pdf |
| Availability: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.650.3598; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787620/pdf/nihms158030.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| Accession Number: | edsbas.F07490B8 |
| Database: | BASE |