| Title: |
Inter-individual variability for high fat diet consumption in inbred C57BL/6 mice |
| Authors: |
de Francesco, Pablo Nicolás; Cornejo, María Paula; Barrile, Franco; García Romero, Guadalupe; Valdivia, Spring; Andreoli, María F.; Perello, Mario |
| Publisher Information: |
Frontiers Media S.A. |
| Collection: |
CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) |
| Subject Terms: |
EATING BEHAVIORS; FOOD INTAKE; INTER-INDIVIDUALITY; OBESITY; PALATABLE FOODS; https://purl.org/becyt/ford/3.1; https://purl.org/becyt/ford/3 |
| Description: |
Since inbred C57BL/6 mice are known to show inter-individual phenotypic variability for some traits, we tested the hypothesis that inbred C57BL/6 mice display a different tendency to consume a high fat (HF) diet. For this purpose, we used a compilation of HF intake data from an experimental protocol in which satiated mice were exposed to a HF pellet every morning for 2-h over 4 consecutive days. We found that mice displayed a large degree of variability in HF intake. Since day 1 HF intake significantly correlated with HF intake in successive days, we applied a hierarchical clustering algorithm on HF intake measurements in days 2, 3, and 4 in order to classify mice into ?low? or ?high? HF intake groups. ?Low? HF intake group showed a day 1 HF intake similar to that seen in mice exposed to regular chow, while ?high? HF intake group showed a higher day 1 HF intake as compared to ?low? HF intake group. Both groups of mice increased HF consumption over the successive days, but ?high? HF intake group always displayed a higher HF consumption than the ?low? HF intake group. As compared to ?low? HF intake group, ?high? HF intake group showed a higher number of dopamine neurons positive for c-Fos in the VTA after the last event of HF intake. Thus, inbred C57BL/6 mice show inter-individual variability for HF intake and such feature may be linked to a different response to the rewarding properties of the HF diet. ; Fil: de Francesco, Pablo Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina ; Fil: Cornejo, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520645/pdf/fnut-06-00067.pdf; info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnut.2019.00067; https://hdl.handle.net/11336/127845; CONICET Digital; CONICET |
| Availability: |
https://hdl.handle.net/11336/127845 |
| Rights: |
info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| Accession Number: |
edsbas.F096877F |
| Database: |
BASE |