30-day Morbidity and Mortality after Cholecystectomy for Benign Gallbladder Disease (AMBROSE): A Prospective, International Collaborative Cohort Study
| Title: | 30-day Morbidity and Mortality after Cholecystectomy for Benign Gallbladder Disease (AMBROSE): A Prospective, International Collaborative Cohort Study |
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| Authors: | Wong G. Y. M.; Wadhawan H.; Roth Cardoso V.; Bravo Merodio L.; Rajeev Y.; Maldonado R. D.; Martinino A.; Balasubaramaniam V.; Ashraf A.; Siddiqui A.; Al-Shkirat A. G.; Mohammed Abu-Elfatth A.; Gupta A.; Alkaseek A.; Ouyahia A.; Said A.; Pandey A.; Kumar A.; Maqbool B.; Millán C. A.; Singh C.; Pantoja Pachajoa D. A.; Adamovich D. M.; Petracchi E.; Ashraf F.; Clementi M.; Mulita F.; Marom G. A.; Abdulaal G.; Verras G. I.; Calini G.; Moretto G.; Elfeki H.; Liang H.; Jalaawiy H.; Elzayat I.; Das J. K.; Aceves-Ayala J. M.; Ahmed K. T.; Degrate L.; Aggarwal M.; Omar M. A.; Rais M.; Elhadi M.; Sakran N.; Bhojwani R.; Agarwalla R.; Kanaan S.; Erdene S.; Chooklin S.; Khuroo S.; Dawani S.; Asghar S. T.; Fung T. K. J.; Omarov T.; Grigorean V. T.; Boras Z.; Gkoutos G. V.; Singhal R.; Mahawar K.; Madhok B.; Graham Y.; Donohoe C.; Reira M.; Vish Y. K. S.; Jain R.; Popat S.; Boddy A.; Jain V.; Marques C. N.; Wazir I.; Pereira J. P. S.; Abouelazayem M.; Viswanath N.; Sarodaya V.; Bala V.; Homayoon R.; Dogjani A.; Tidjane A.; Antozzi L.; Hong J.; Dash A. K.; Chokshi A.; Wietzycoski C. R.; Petkov P.; Mbonicura J. C.; Yang W.; Zuluaga M.; Kraljik D.; Lincango Naranjo E. P.; Elghadban H. M.; Diaz A.; Gerogiannis I.; Mohammed A.; Lazaros L.; Bhasker A. G.; Kermansaravi M.; Mahdi A. S.; Kayyal M. Y.; Frattini F.; Ferrara F |
| Contributors: | Wong G.Y.M.; Wadhawan H.; Roth Cardoso V.; Bravo Merodio L.; Rajeev Y.; Maldonado R.D.; Martinino A.; Balasubaramaniam V.; Ashraf A.; Siddiqui A.; Al-Shkirat A.G.; Mohammed Abu-Elfatth A.; Gupta A.; Alkaseek A.; Ouyahia A.; Said A.; Pandey A.; Kumar A.; Maqbool B.; Millán C.A.; Singh C.; Pantoja Pachajoa D.A.; Adamovich D.M.; Petracchi E.; Ashraf F.; Clementi M.; Mulita F.; Marom G.A.; Abdulaal G.; Verras G.I.; Calini G.; Moretto G.; Elfeki H.; Liang H.; Jalaawiy H.; Elzayat I.; Das J.K.; Aceves-Ayala J.M.; Ahmed K.T.; Degrate L.; Aggarwal M.; Omar M.A.; Rais M.; Elhadi M.; Sakran N.; Bhojwani R.; Agarwalla R.; Kanaan S.; Erdene S.; Chooklin S.; Khuroo S.; Dawani S.; Asghar S.T.; Fung T.K.J.; Omarov T.; Grigorean V.T.; Boras Z.; Gkoutos G.V.; Singhal R.; Mahawar K.; Madhok B.; Graham Y.; Donohoe C.; Reira M.; Vish Y.K.S.; Jain R.; Popat S.; Boddy A.; Jain V.; Marques C.N.; Wazir I.; Pereira J.P.S.; Abouelazayem M.; Viswanath N.; Sarodaya V.; Bala V.; Homayoon R.; Dogjani A.; Tidjane A.; Antozzi L.; Hong J.; Dash A.K.; Chokshi A.; Wietzycoski C.R.; Petkov P.; Mbonicura J.C.; Yang W.; Zuluaga M.; Kraljik D.; Lincango Naranjo E.P.; Elghadban H.M.; Diaz A.; Gerogiannis I.; Mohammed A.; Lazaros L.; Bhasker A.G.; Kermansaravi M.; Mahdi A.S.; Kayyal M.Y.; Frattini F. |
| Publisher Information: | LIPPINCOTT WILLIAMS & WILKINS |
| Publication Year: | 2025 |
| Collection: | IRIS Università degli Studi di Palermo |
| Subject Terms: | benign gallbladder disease; bile duct injury; cholecystectomy; complications; morbidity; mortality |
| Description: | Objective:This study aimed to assess 30-day morbidity and mortality rates following cholecystectomy for benign gallbladder disease and identify the factors associated with complications.Background:Although cholecystectomy is common for benign gallbladder disease, there is a gap in the knowledge of the current practice and variations on a global level.Methods:A prospective, international, observational collaborative cohort study of consecutive patients undergoing cholecystectomy for benign gallbladder disease from participating hospitals in 57 countries between January 1 and June 30, 2022, was performed. Univariate and multivariate logistic regression models were used to identify preoperative and operative variables associated with 30-day postoperative outcomes.Results:Data of 21,706 surgical patients from 57 countries were included in the analysis. A total of 10,821 (49.9%), 4263 (19.7%), and 6622 (30.5%) cholecystectomies were performed in the elective, emergency, and delayed settings, respectively. Thirty-day postoperative complications were observed in 1738 patients (8.0%), including mortality in 83 patients (0.4%). Bile leaks (Strasberg grade A) were reported in 278 (1.3%) patients, and severe bile duct injuries (Strasberg grades B-E) were reported in 48 (0.2%) patients. Patient age, American Society of Anesthesiologists physical status class, surgical setting, operative approach, and Nassar operative difficulty grade were identified as the 5 predictors demonstrating the highest relative importance in predicting postoperative complications.Conclusions:This multinational observational collaborative cohort study presents a comprehensive report of the current practices and outcomes of cholecystectomy for benign gallbladder disease. Ongoing global collaborative evaluations and initiatives are needed to promote quality assurance and improvement in cholecystectomy. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38348652; info:eu-repo/semantics/altIdentifier/wos/WOS:001394746100001; volume:281; issue:2; firstpage:312; lastpage:321; numberofpages:10; journal:ANNALS OF SURGERY; https://hdl.handle.net/10447/674967; https://pmc.ncbi.nlm.nih.gov/articles/PMC11723498/ |
| DOI: | 10.1097/SLA.0000000000006236 |
| Availability: | https://hdl.handle.net/10447/674967; https://doi.org/10.1097/SLA.0000000000006236; https://pmc.ncbi.nlm.nih.gov/articles/PMC11723498/ |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.F0AC6B3A |
| Database: | BASE |